메뉴 건너뛰기




Volumn 8, Issue 2, 2013, Pages

Influence of the Serotonin Transporter 5HTTLPR Polymorphism on Symptom Severity in Irritable Bowel Syndrome

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; MESSENGER RNA; SEROTONIN TRANSPORTER;

EID: 84873488381     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054831     Document Type: Article
Times cited : (41)

References (44)
  • 3
    • 34248173349 scopus 로고    scopus 로고
    • Clinical update: irritable bowel syndrome
    • Spiller R, (2007) Clinical update: irritable bowel syndrome. Lancet 369: 1586-1588.
    • (2007) Lancet , vol.369 , pp. 1586-1588
    • Spiller, R.1
  • 4
    • 33846697322 scopus 로고    scopus 로고
    • New insights into the pathogenesis and pathophysiology of irritable bowel syndrome
    • Ohman L, Simren M, (2007) New insights into the pathogenesis and pathophysiology of irritable bowel syndrome. Dig Liver Dis 39: 201-215.
    • (2007) Dig Liver Dis , vol.39 , pp. 201-215
    • Ohman, L.1    Simren, M.2
  • 5
    • 79951567291 scopus 로고    scopus 로고
    • Traditional thoughts on the pathophysiology of irritable bowel syndrome
    • Hasler WL, (2011) Traditional thoughts on the pathophysiology of irritable bowel syndrome. Gastroenterol Clin North Am 40: 21-43.
    • (2011) Gastroenterol Clin North Am , vol.40 , pp. 21-43
    • Hasler, W.L.1
  • 7
  • 8
    • 33847725853 scopus 로고    scopus 로고
    • Mechanisms of disease: genetics of functional gastrointestinal disorders-searching the genes that matter
    • Adam B, Liebregts T, Holtmann G, (2007) Mechanisms of disease: genetics of functional gastrointestinal disorders-searching the genes that matter. Nat Clin Pract Gastroenterol Hepatol 4: 102-110.
    • (2007) Nat Clin Pract Gastroenterol Hepatol , vol.4 , pp. 102-110
    • Adam, B.1    Liebregts, T.2    Holtmann, G.3
  • 11
    • 67651048604 scopus 로고    scopus 로고
    • Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention
    • Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, et al. (2009) Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention. Neuroimage 47: 946-951.
    • (2009) Neuroimage , vol.47 , pp. 946-951
    • Fukudo, S.1    Kanazawa, M.2    Mizuno, T.3    Hamaguchi, T.4    Kano, M.5
  • 12
    • 0034297908 scopus 로고    scopus 로고
    • Serotonin: a mediator of the brain-gut connection
    • Kim DY, Camilleri M, (2000) Serotonin: a mediator of the brain-gut connection. Am J Gastroenterol 95: 2698-2709.
    • (2000) Am J Gastroenterol , vol.95 , pp. 2698-2709
    • Kim, D.Y.1    Camilleri, M.2
  • 13
    • 23244446441 scopus 로고    scopus 로고
    • Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome
    • Gershon MD, (2005) Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. J Clin Gastroenterol 39: S184-193.
    • (2005) J Clin Gastroenterol , vol.39
    • Gershon, M.D.1
  • 14
    • 0031681197 scopus 로고    scopus 로고
    • Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception
    • Chen JX, Pan H, Rothman TP, Wade PR, Gershon MD, (1998) Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception. Am J Physiol 275: G433-448.
    • (1998) Am J Physiol , vol.275
    • Chen, J.X.1    Pan, H.2    Rothman, T.P.3    Wade, P.R.4    Gershon, M.D.5
  • 15
    • 33646870356 scopus 로고    scopus 로고
    • Review article: intestinal serotonin signalling in irritable bowel syndrome
    • Mawe GM, Coates MD, Moses PL, (2006) Review article: intestinal serotonin signalling in irritable bowel syndrome. Aliment Pharmacol Ther 23: 1067-1076.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1067-1076
    • Mawe, G.M.1    Coates, M.D.2    Moses, P.L.3
  • 16
    • 46049102966 scopus 로고    scopus 로고
    • The genetics of the serotonin transporter and irritable bowel syndrome
    • Colucci R, Blandizzi C, Bellini M, Ghisu N, Tonini M, et al. (2008) The genetics of the serotonin transporter and irritable bowel syndrome. Trends Mol Med 14: 295-304.
    • (2008) Trends Mol Med , vol.14 , pp. 295-304
    • Colucci, R.1    Blandizzi, C.2    Bellini, M.3    Ghisu, N.4    Tonini, M.5
  • 17
    • 0029895783 scopus 로고    scopus 로고
    • Allelic variation of human serotonin transporter gene expression
    • Heils A, Teufel A, Petri S, Stober G, Riederer P, et al. (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66: 2621-2624.
    • (1996) J Neurochem , vol.66 , pp. 2621-2624
    • Heils, A.1    Teufel, A.2    Petri, S.3    Stober, G.4    Riederer, P.5
  • 18
    • 0034751716 scopus 로고    scopus 로고
    • Variation of serotonergic gene expression: neurodevelopment and the complexity of response to psychopharmacologic drugs
    • Lesch KP, (2001) Variation of serotonergic gene expression: neurodevelopment and the complexity of response to psychopharmacologic drugs. Eur Neuropsychopharmacol 11: 457-474.
    • (2001) Eur Neuropsychopharmacol , vol.11 , pp. 457-474
    • Lesch, K.P.1
  • 19
    • 0006463359 scopus 로고    scopus 로고
    • Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
    • Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531.
    • (1996) Science , vol.274 , pp. 1527-1531
    • Lesch, K.P.1    Bengel, D.2    Heils, A.3    Sabol, S.Z.4    Greenberg, B.D.5
  • 20
    • 2542447453 scopus 로고    scopus 로고
    • Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression
    • Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, et al. (2004) Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry 55: 1090-1094.
    • (2004) Biol Psychiatry , vol.55 , pp. 1090-1094
    • Hranilovic, D.1    Stefulj, J.2    Schwab, S.3    Borrmann-Hassenbach, M.4    Albus, M.5
  • 21
    • 84862832232 scopus 로고    scopus 로고
    • Serotonin transporter gene promoter region polymorphisms and serotonin transporter expression in the colonic mucosa of irritable bowel syndrome patients
    • Wang YM, Chang Y, Chang YY, Cheng J, Li J, et al. (2012) Serotonin transporter gene promoter region polymorphisms and serotonin transporter expression in the colonic mucosa of irritable bowel syndrome patients. Neurogastroenterol Motil 24: 560-e255.
    • (2012) Neurogastroenterol Motil , vol.24
    • Wang, Y.M.1    Chang, Y.2    Chang, Y.Y.3    Cheng, J.4    Li, J.5
  • 22
    • 34548699118 scopus 로고    scopus 로고
    • Meta-analysis: a functional polymorphism in the gene encoding for activity of the serotonin transporter protein is not associated with the irritable bowel syndrome
    • Van Kerkhoven LA, Laheij RJ, Jansen JB, (2007) Meta-analysis: a functional polymorphism in the gene encoding for activity of the serotonin transporter protein is not associated with the irritable bowel syndrome. Aliment Pharmacol Ther 26: 979-986.
    • (2007) Aliment Pharmacol Ther , vol.26 , pp. 979-986
    • Van Kerkhoven, L.A.1    Laheij, R.J.2    Jansen, J.B.3
  • 23
    • 4644293513 scopus 로고    scopus 로고
    • Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women
    • Yeo A, Boyd P, Lumsden S, Saunders T, Handley A, et al. (2004) Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut 53: 1452-1458.
    • (2004) Gut , vol.53 , pp. 1452-1458
    • Yeo, A.1    Boyd, P.2    Lumsden, S.3    Saunders, T.4    Handley, A.5
  • 24
    • 2442677620 scopus 로고    scopus 로고
    • Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders
    • Kim HJ, Camilleri M, Carlson PJ, Cremonini F, Ferber I, et al. (2004) Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut 53: 829-837.
    • (2004) Gut , vol.53 , pp. 829-837
    • Kim, H.J.1    Camilleri, M.2    Carlson, P.J.3    Cremonini, F.4    Ferber, I.5
  • 25
    • 33846281529 scopus 로고    scopus 로고
    • Change over time of bowel habit in irritable bowel syndrome: a prospective, observational, 1-year follow-up study (RITMO study)
    • Garrigues V, Mearin F, Badia X, Balboa A, Benavent J, et al. (2007) Change over time of bowel habit in irritable bowel syndrome: a prospective, observational, 1-year follow-up study (RITMO study). Aliment Pharmacol Ther 25: 323-332.
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 323-332
    • Garrigues, V.1    Mearin, F.2    Badia, X.3    Balboa, A.4    Benavent, J.5
  • 26
    • 0030942155 scopus 로고    scopus 로고
    • The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress
    • Francis CY, Morris J, Whorwell PJ, (1997) The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther 11: 395-402.
    • (1997) Aliment Pharmacol Ther , vol.11 , pp. 395-402
    • Francis, C.Y.1    Morris, J.2    Whorwell, P.J.3
  • 28
    • 0028338434 scopus 로고
    • Basic and clinical aspects of visceral hyperalgesia
    • Mayer EA, Gebhart GF, (1994) Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 107: 271-293.
    • (1994) Gastroenterology , vol.107 , pp. 271-293
    • Mayer, E.A.1    Gebhart, G.F.2
  • 29
    • 67651048604 scopus 로고    scopus 로고
    • Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention
    • Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, et al. (2009) Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention. Neuroimage 47: 946-951.
    • (2009) Neuroimage , vol.47 , pp. 946-951
    • Fukudo, S.1    Kanazawa, M.2    Mizuno, T.3    Hamaguchi, T.4    Kano, M.5
  • 30
    • 0034107656 scopus 로고    scopus 로고
    • Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention
    • Mertz H, Morgan V, Tanner G, Pickens D, Price R, et al. (2000) Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention. Gastroenterology 118: 842-848.
    • (2000) Gastroenterology , vol.118 , pp. 842-848
    • Mertz, H.1    Morgan, V.2    Tanner, G.3    Pickens, D.4    Price, R.5
  • 31
    • 22844433107 scopus 로고    scopus 로고
    • 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    • Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, et al. (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8: 828-834.
    • (2005) Nat Neurosci , vol.8 , pp. 828-834
    • Pezawas, L.1    Meyer-Lindenberg, A.2    Drabant, E.M.3    Verchinski, B.A.4    Munoz, K.E.5
  • 32
    • 0037624040 scopus 로고    scopus 로고
    • Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    • Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, et al. (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301: 386-389.
    • (2003) Science , vol.301 , pp. 386-389
    • Caspi, A.1    Sugden, K.2    Moffitt, T.E.3    Taylor, A.4    Craig, I.W.5
  • 34
    • 3142620973 scopus 로고    scopus 로고
    • Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review
    • Smits KM, Smits LJ, Schouten JS, Stelma FF, Nelemans P, et al. (2004) Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review. Mol Psychiatry 9: 433-441.
    • (2004) Mol Psychiatry , vol.9 , pp. 433-441
    • Smits, K.M.1    Smits, L.J.2    Schouten, J.S.3    Stelma, F.F.4    Nelemans, P.5
  • 35
    • 33845309080 scopus 로고    scopus 로고
    • Serotonin transporter gene variants and behavior: a comprehensive review
    • Serretti A, Calati R, Mandelli L, De Ronchi D, (2006) Serotonin transporter gene variants and behavior: a comprehensive review. Curr Drug Targets 7: 1659-1669.
    • (2006) Curr Drug Targets , vol.7 , pp. 1659-1669
    • Serretti, A.1    Calati, R.2    Mandelli, L.3    De Ronchi, D.4
  • 36
    • 61649089108 scopus 로고    scopus 로고
    • Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis
    • Ford AC, Talley NJ, Schoenfeld PS, Quigley EM, Moayyedi P, (2009) Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis. Gut 58: 367-378.
    • (2009) Gut , vol.58 , pp. 367-378
    • Ford, A.C.1    Talley, N.J.2    Schoenfeld, P.S.3    Quigley, E.M.4    Moayyedi, P.5
  • 37
    • 4644226729 scopus 로고    scopus 로고
    • [Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome]
    • Lee DY, Park H, Kim WH, Lee SI, Seo YJ, et al. (2004) [Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome]. Korean J Gastroenterol 43: 18-22.
    • (2004) Korean J Gastroenterol , vol.43 , pp. 18-22
    • Lee, D.Y.1    Park, H.2    Kim, W.H.3    Lee, S.I.4    Seo, Y.J.5
  • 38
    • 34250172717 scopus 로고    scopus 로고
    • A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome
    • Saito YA, Locke GR, 3rd, Zimmerman JM, Holtmann G, Slusser JP, et al (2007) A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome. Neurogastroenterol Motil 19: 465-470.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 465-470
    • Saito, Y.A.1    Locke 3rd, G.R.2    Zimmerman, J.M.3    Holtmann, G.4    Slusser, J.P.5
  • 39
    • 70350001480 scopus 로고    scopus 로고
    • The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome
    • Kohen R, Jarrett ME, Cain KC, Jun SE, Navaja GP, et al. (2009) The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome. Dig Dis Sci 54: 2663-2670.
    • (2009) Dig Dis Sci , vol.54 , pp. 2663-2670
    • Kohen, R.1    Jarrett, M.E.2    Cain, K.C.3    Jun, S.E.4    Navaja, G.P.5
  • 40
    • 77954019708 scopus 로고    scopus 로고
    • 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex
    • Niesler B, Kapeller J, Fell C, Atkinson W, Moller D, et al. (2010) 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex. Eur J Gastroenterol Hepatol 22: 856-861.
    • (2010) Eur J Gastroenterol Hepatol , vol.22 , pp. 856-861
    • Niesler, B.1    Kapeller, J.2    Fell, C.3    Atkinson, W.4    Moller, D.5
  • 42
    • 74949108129 scopus 로고    scopus 로고
    • Serotonin transporter promoter variant: Analysis in Indian IBS patients and control population
    • Sikander A, Rana SV, Sinha SK, Prasad KK, Arora SK, et al. (2009) Serotonin transporter promoter variant: Analysis in Indian IBS patients and control population. J Clin Gastroenterol 43: 957-961.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 957-961
    • Sikander, A.1    Rana, S.V.2    Sinha, S.K.3    Prasad, K.K.4    Arora, S.K.5
  • 43
    • 34548675656 scopus 로고    scopus 로고
    • The association of serotonin transporter genetic polymorphisms and irritable bowel syndrome and its influence on tegaserod treatment in Chinese patients
    • Li Y, Nie Y, Xie J, Tang W, Liang P, et al. (2007) The association of serotonin transporter genetic polymorphisms and irritable bowel syndrome and its influence on tegaserod treatment in Chinese patients. Dig Dis Sci 52: 2942-2949.
    • (2007) Dig Dis Sci , vol.52 , pp. 2942-2949
    • Li, Y.1    Nie, Y.2    Xie, J.3    Tang, W.4    Liang, P.5
  • 44
    • 51549102758 scopus 로고    scopus 로고
    • Ethnic differences in the serotonin transporter polymorphism (5-HTTLPR) in several European populations
    • Noskova T, Pivac N, Nedic G, Kazantseva A, Gaysina D, et al. (2008) Ethnic differences in the serotonin transporter polymorphism (5-HTTLPR) in several European populations. Prog Neuropsychopharmacol Biol Psychiatry 32: 1735-1739.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 1735-1739
    • Noskova, T.1    Pivac, N.2    Nedic, G.3    Kazantseva, A.4    Gaysina, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.