Drug resistance in African trypanosomiasis

Antimicrobial Resistance in Developing Countries

Volumn 9780387893709, Issue , 2010, Pages 157-176

  Matovu, Enock ^a   Mäser, Pascal ^b  

^a MAKERERE UNIVERSITY   (Uganda)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84873483655     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-89370-9_10     Document Type: Chapter

References (95)

1. Alibu, V. P., Richter C., Voncken, F., Marti, G., Shahi, S., Renggli, C. K., Seebeck, T., Brun, R. and Clayton, C. 2006. The role of Trypanosoma brucei MRPA in melarsoprol susceptibility. Mol. Biochem. Parasitol. 146, 38-44.
2. Aliu, Y. O., Mamman, M. and Peregrine, A. S. 1993. Pharmacokinetics of diminazene in female Boran (Bos indicus) cattle. J. Vet. Pharmacol. Therap. 16, 291-300.
3. Arinayagam, M. R., Oza, S. L., Guther, M. L. S. and Fairlamb, A. H. 2005. Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome. Biochem. J. 391, 425-432.
4. Armstrong, V. L. and Smith, C. C. 1974. Cyclization and N dealkylation of chloroguanide by rabbit and rat hepatic microsomes. Toxicol. Appl. Pharmacol. 29, 90.
5. Bacchi, C. J., Nathan, H. C., Hutner, S. H., McCann, P. P., and Sjerdsma, A. 1980. Polyamine metabolism: a potential therapeutic target in trypanosomes. Science 210, 332-334.
6. Bales, J. D., Harrison, S. M., Mbwabi, D. L. and Schechter, P. J. 1989. Treatment of arsenical refractory Rhodesian sleeping sickness in Kenya. Ann. Trop. Med. Parasitol. 83, 111-114.
7. Berberof, M., Perez-Morga, D. and Pays, E. 2001. A receptor-like flagellar pocket glycoprotein specific to Trypanosoma brucei gambiense. Mol. Biochem. Parasitol. 113, 127-138.
8. Bernhard, S., Nerima, B., Maser, P. and Brun, R. 2007. Melarsoprol- and pentamidineresistant Trypanosoma brucei rhodesiense populations and their cross-resistance. Int. J. Parasitol. 37, 1443-1448.
9. Bisser S., N'Siesi, F-X., Lejon, V., Preux, P-M., Van Nieuwenhove, S., Miaka, C. and Buscher P. 2007. Equivalence trail of melarsoprol and Nifurtimox monotherapy and combination therapy for the treatment of second stage trypanosome brucei gambiense sleeping sickness. J. Infect. Dis. 195, 322-329.
10. Boid, R., Jones, T. W. and Payne, R. C., 1989. Malic enzyme VII isoenzyme as an indicator of suramin resistance in Trypanosoma evansi. Exp Parasitol. 69, 317-323.
11. Burri, C., Baltz, T., Giroud, C., Doua, F., Welker, H. A. and Brun, R. 1993. Pharmacokinetic properties of the trypanocidal drug melarsoprol. Chemotherapy 39, 225-234.
12. Carter, N. S. and Fairlamb, A. H. 1993. Arsenical resistant trypanosomes lack an unusual adenosine transporter. Nature 361:173-175.
13. Carter, N. S., Berger, B. J. and Fairlamb, A. H. 1995. Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei. J. Biol. Chem. 270, 28153-28157.
14. Chitambo, H., Arakawa, A. and Ono, T. 1992. In vivo assessment of drug sensitivity of African trypanosomes using the akinetoplastic induction test. Res. Vet. Sci. 52, 243-249.
15. Cortazar, T. M., Coombs, G. H. and Walker, J. 2007. Leishmania panamensis: comparative inhibition of nuclear DNA topoisomerase II enzymes from promastigotes and human macrophages reveals anti-parasite selectivity of fluoroquinolones, flavanoids and pentamidin. Exp. Parasitol. 116, 475-482.
16. Degen R., Pospichal H., Enyaru J. and Jenni L. 1995. Sexual compatibility among Trypanosoma brucei isolates from an epidemic area in south-eastern Uganda. Parasitol. Res. 81, 253-257.
17. De Gee, A. L. W., McCann, P. P. and Mansfield, J. M. 1983. Role ofantibodyin the elimination of trypanosomes after DL-a-difluoromethylornithine chemotherapy. J. Parasitol. 69, 818-822.
18. de Koning, H. 2001. Uptake of pentamidine in Trypanosoma brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. Mol. Pharmacol. 59, 586-592.
19. de Koning, H. P., Anderson, L. F., Stewart, M., Burchmore, R. J., Wallace, L. J. and Barrett, M. P. 2004. The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrob. Agents Chemother. 48, 1515-1519.
20. Delespaux, V., Chitanga, S., Geysen, D., Goethals, A. P., Van den Bossche, P. and Geerts, S. 2006. SSCP analysis of the P2 purine transporter TcoAT1 gene of Trypanosoma congolense leads to a simple PCR-RFLP test allowing the rapid identification of diminazene resistant stocks. Acta Trop. 100, 96-102.
21. Dey, S., Papadopoulou, B., Haimeur, A., Roy, G., Grondin, K., Dou, D., Rosen, B. P. and Ouellette, M. 1994. High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system. Mol. Biochem. Parasitol. 67, 49-57.
22. Diggens, S. M., Gutteridge, W. E. and Trigg, P. I. 1970. An altered dihydrofolate reductase associated with pyrimethamine resistant P. bergei produced in a single step. Nature 228, 579-580.
23. El Rayah, I. E., Kaminsky, R., Schmid, C. and El Malikh, K. H. 1999. Drug resistance in Sudanese Trypanosoma evansi. Vet. Parasitol. 80, 281-287.
24. Fairlamb, A. H. 2003. Chemotherapy of human African trypanosomiasis: current and future prospects. Trends Parasitol. 19, 488-494.
25. Fairlamb, A. H. and Bowman, I. B. R. 1977. Trypanosoma brucei: suramin and other trypanocidal compounds effects on glycerol-3-phosphate oxidase. Exp. Parasitol. 43, 353-361.
26. Fairlamb, A. H. and Bowman, I. B. R. 1980. Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effects on respiration and growth rate in vivo. Mol. Biochem. Parasitol. 1, 315-333.
27. Foote, S. J. and Cowman, A. F. 1994. The mode of action and the mechanism of resistance to antimalarial drugs. Acta Trop. 56, 157-171.
28. Frommel, T. O. and Balber, A. E. 1987. Flow cytofluorimetric analysis of drug accumulation by multidrug-resistant Trypanosoma brucei brucei and T. b. rhodesiense. Mol. Biochem. Parasitol. 26, 183-192.
29. Fulton, J. D. and Grant, P. T. 1955. The preparation of a strain of Trypanosoma rhodesiense resistant to stilbamidine and some observations on its nature. Ann. Trop. Med. Parasitol. 49, 377-387.
30. Gibson, W., Backhouse, T. and Griffiths, A. 2002. The human serum associated gene is ubiquitous and conserved in Trypanosoma brucei rhodesiense throughout East Africa. Infect. Genet. Evol. 1, 207-214.
31. Gibson, W. and Whittington, H. 1993. Genetic exchange in Trypanosoma brucei: selection of hybrid trypanosomes by introduction of genes conferring drug resistance. Mol. Biochem. Parasitol. 60, 19-26.
32. Giraldo, L. E., Acosta, M. C., Labrada, L. A., Praba, A., Montanegro-James, S., Saravia, N. G. and Krogstad, D. J. 1998. Frequency of the asn-108 and Thr-108 point mutations in the dihydrofolate reductase gene in Plasmodium falciparum from southwest Columbia. Am. J. Trop. Med. Hyg. 59, 124-128.
33. Hawking, F. 1936. The absorption of arsenical compounds and tartar emetic by normal and resistant trypanosomes and its relation to drug-resistance. J. Pharm. Exp. Therap. 59, 123-156.
34. Hawking, F. 1963a. Drug resistance of Trypanosoma congolense and other trypanosomes to quinapyramine, penanthridines, Berenil and other compounds in mice. Ann. Trop. Med. Parasitol. 57, 262-282.
35. Hawking, F. 1963b. History of chemotherapy. In Experimental chemotherapy Ed R. J. Schnitzer, and F. Hawking. New York, Academic Press, Vol I, pp. 2-3.
36. Hesse, F., Sezer, P. M., Muhlstadt, K. and Duszenko, M. 1995. A novel cultivation technique for long-term maintenance of bloodstream form trypanosomes in vitro. Mol. Biochem. Parasitol. 70, 157-166.
37. Hoare, C. A. 1972. The trypanosomes of mammals: a zoological monograph. Oxford: Blackwell.
38. Iten, M., Matovu, E., Brun, R. and Kaminsky, R. 1995. Innate lack of susceptibility of Ugandan Trypanosoma brucei rhodesiense to DL-a-difluorometylornithine (DFMO). Trop. Med. Parasitol. 46, 190-194.
39. Iten, M., Mett, H., Evans, A., Enyaru, J. C. K., Brun, R. and Kaminsky R. 1997. Alterations in ornithine decarboxylase characteristics account for tolerance of Trypanosoma brucei rhodesiense to DL-a-difluoromethylornithine. Antimicrob. Agents Chemoth. 41, 1922-1925.
40. Jenni, L., Marti, S., Schweizer, J., Betschart, B., Le Page, W. F., Wells, J. M., Tait, A., Paindavoine., Pays, E. and Steinert, M. 1986. Hybrid formation between African trypanosomes during cyclical transmission. Nature 322, 173-175.
41. Jennings, F. W., Whitelaw, D. D., Chizyuka, H. G. B., Holmes, P. H. and Urquhart, G. 1979. The brain as a source of relapsing Trypanosoma brucei infections in mice after chemotherapy. Int. J. Parasitol. 9, 381-384.
42. Kaminsky, R., Gumm, L. D., Zweygarth, E. and Chuma, F. 1990. A drug incubation infectivity test DIIT for assessing resistance in trypanosomes. Vet. Parasitol. 34, 335-343.
43. Keiser, J., Ericson, O. and Burri, C. 2000. Investigations on the metabolites of the trypanocidal drug melarsoprol. Clin. Pharmacol. Therap. 67, 478-488.
44. Kinabo, L. D. B. and Bogan, J. A. 1988. Pharmacokinetic and histopathological investigations of isometamidium in cattle. Res. Vet. Sci. 44, 267-269.
45. Kinabo, L. D. B, McKellar, Q. A., and Eckersall, P. D. 1991. Isometamidium in pigs: disposition kinetics, tissue residues and adverse reactions. Res. Vet. Sci. 50, 6-13.
46. Kuzoe, F. A. S. 1993. Current situation of African trypanosomiasis. Acta Trop. 54, 153-162.
47. Lanteri, C., Stewart, M., Brock, J., Alibu, V., Meshnick, S., Tidwell, R. and Barrett, M. 2006. Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance. Mol. Pharmacol. 70, 1585-1592.
48. Lanteri, C. A., Trumpower, B. L., Tidwell, R. R. and Meshnick, S. R. 2004. DB75, a novel trypanocidalagent disrupts mitochondrial function in Saccharomyces cerevisiae. Antimicrob. Agents Chemoth. 48, 3968-3974.
49. Legros, D., Evans, S., Maiso, F., Enyaru, J. C. K. and Mbulamberi, D. 1999. Risk factors for treatment failure after melarsoprol for Trypanosoma brucei gambiense trypanosomiasis in Uganda. Trans. R. Soc. Trop. Med. Parasitol. 93, 439-442.
50. Lester, H. M. O. 1939. Certain aspects of trypanosomiasis in some African independencies. Trans. R. Soc. Trop. Med. Hyg. 33, 11-36.
51. Luckins, A. G., Boid, R., Rae, P., Mahmoud, M. M., Malik, K. H. and Gray, A. R. 1979. Serodiagnosis of infection with T. evansi in camels in Sudan. Trop. Anim. Health Prod. 11, 1-12.
52. Luscher, A., Nerima, B. and Maser, P. 2006. Combined contribution of TbAT1 and TbMRPA to drug resistance in Trypanosoma brucei. Mol. Biochem. Parasitol. 150, 364-366.
53. MacAdam, R. F. and Williamson, J. 1972. Drug effects on the fine structure of Trypanosoma rhodesiense: diamidines. Trans. R. Soc. Trop. Med. Hyg. 66, 897-904.
54. Mamman, M. and Peregrine, A. S. 1994. Pharmacokinetics of diminazene in plasma and cerebrospinal fluid of goats. Res. Vet. Sci. 57, 253-255.
55. Maina, N., Maina, K., Maser, P. and Brun, R. 2007. Genotypic and phenotypic characterization of Trypanosoma brucei gambiense isolates from Ibba, South Sudan, an area of high melarsoprol treatment failure rate. Acta Trop. 104, 84-90.
56. Maser, P., Sutterlin, C., Kralli, A. and Kaminsky, R. 1999. A nucleoside transporter from Trypanosoma brucei involved in drug resistance. Science 285, 242-244.
57. Maser, P. and Kaminsky, R. 1998. Identification of three ABC transporter genes in Trypanosoma brucei spp. Parasitol. Res. 84, 106-111.
58. Maser, P., Luscher, A. and Kaminsky, R. 2003. Drug transport and drug resistance in African trypanosomes. Drug Resist. Update 6, 281-290.
59. Matovu, E., Iten, M., Enyaru, J. C. K., Schmid, C., Lubega, G. W., Brun, R. and Kaminsky, R. 1997. Susceptibility of Ugandan Trypanosoma brucei rhodesiense isolated from man and animal reservoirs to diminazene, isometamidium and melarsoprol. Trop. Med. Int. Health 2, 13-18.
60. Matovu, E., Geiser, F., Schneider, V., Maser, P., Enyaru, J. C. K., Kaminsky, R., Gallati, S. and Seebeck, T. 2001. Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy. Mol. Biochem. Parasitol. 117, 73-81.
61. Matovu, E., Stewart, M. L., Geiser, F., Brun, R., Maser, P., Wallace, L. J., Burchmore, R. J., Enyaru, J. C., Barrett, M. P., Kaminsky, R., Seebeck, T. and de Koning, H. P. 2003. The mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Euk. Cell. 2, 1003-1008.
62. Molyneux, D. H. and Ashford, R. W. 1983. The biology of Trypanosoma and Leishmania, Parasites of man and domestic animals. Taylor & Fransis, London.
63. Mulligan, H. W. (ed) 1970. The African trypanosomiases. London: George Allen & Unwin.
64. Nerima, B., Matovu, E., Lubega, G. and Enyaru, J. 2007. Detection of mutant P2 adenosine transporter TbAT1) gene in Trypanosoma brucei gambiense isolates from northwest Uganda using allele-specific polymerase chain reaction. Trop. Med Int. Health 12, 1361-1368.
65. Okoth, J. O., Kirumira, E. K. and Kapaata, R. 1991. A new approach to community participation in tsetse control in the Busoga Sleeping sickness focus, Uganda. A preliminary report. Ann. Trop. Med. Parasitol. 85, 315-322.
66. Ouellette, M. and Papadopoulou, B. 1993. Mechanisms of drug resistance in Leishmania. Parasitol. Today 9, 150-153.
67. Ouellette, M., Fase-Fowler, F. and Borst, P. 1990. The amplified H-circle of methotrexateresistant Leishmania tarentolae contains a novel P-glycoprotein. EMBO J. 9, 1027-1033.
68. Ouellette, M., Hettema, E., Wust, D., Fase-Fowler, F. and Borst, P. 1991. Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania. EMBO J. 10, 1009-1016.
69. Overath, P., Chaudri, M., Steverdig, D. and Ziegelbauer, K. 1994. Invariant surface proteins in bloodstream forms of Trypanosoma brucei. Parasitol. Today 10, 53-58.
70. Pepin, J. and Milord, F. 1991. African trypanosomiasis and drug-induced encephalopathy; risk factors and pathogenesis. Trans. R. Soc. Trop. Med. Hyg. 85, 222-224.
71. Pepin, J. and Milord, F. 1994. The treatment of human African trypanosomiasis. Adv. Parasitol. 33, 1-47.
72. Radwanska, M., Claes, F., Magez, S., Magnus, E., Perez-Morga, D., Pays, E. and Buscher, P. 2002a. Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense. Am. J. Trop. Med. Hyg. 67, 289-295.
73. Radwanska, M., Chamekh, M., Vanhamme, L., Claes, F., Magez, S., Magnus, E., deBaetselier, P., Buscher, P. and Pays, E. 2002b. The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense. Am. J. Trop. Med. Hyg. 67, 684-690.
74. Reeder, J. C., Riekmann, K. H., Genton, B., Lorry, K., Wines, B. and Cowman, A. F. 1996. Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimathamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea. Am. J. Trop. Med. Hyg. 55, 209-213.
75. Schweingruber, M. 2004. The melaminophenyl arsenicals melarsoprol and melarsen oxide interfere with thiamine metabolism in the fission yeast Schizosaccharomyces pombe. Antimicrob. Agents Chemoth. 48, 3268-3271.
76. Shahi, S. K., Krauth-Siegel, R. L. and Clayton, C. E. 2002. Over-expression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei. Mol. Microbiol. 43, 1129-1138.
77. Stoffel, S., Rodenko, B., Schweingruber, A., Maser, P., de Koning, H. and Schweingruber, M. 2006. Biosynthesis and uptake of thiamine vitamin B1. in bloodstream form Trypanosoma brucei brucei and interference of the vitamin with melarsen oxide activity. Int. J. Parasitol. 36, 229-236.
78. Suswam, E. A., Ross, C. A. and Martin, R. J. 2003. Changes in adenosine transport associated with melanophenyl arsenical (Mel CY. resiatnce in Trypanosoma evansi: down-regulation and affinity changes of the P2 transporter. Parasitology 127, 543-549.
79. Sutherland, I. A., Mounsey, A. and Holmes, P. H. (1992). Transport of isometamidium (Samorin) by drug resistant and drug sensitive Trypanosoma congolense. Parasitology 104, 461-467.
80. Sutherland, I. A. and Holmes, P. H. 1993. Alterations in drug transport in resistant Trypanosoma congolense, Acta Trop. 54, 271-278.
81. Szyniarowski, P., Bettendorff, L. and Schweingruber, M. 2006. The anti-trypanosomal drug melarsoprol competitively inhibits thiamin uptake in mouse neuroblastoma cells. Cell Biol. Toxicol. 22, 183-187.
82. Turner, M. J. 1985. The biochemistry of the surface antigens of African trypanosomes. Br. Med. Bull. 41, 137-143.
83. Upcroft, P. 1994. Multiple drug resistance in the pathogenic protozoa. Acta Trop. 56, 195-212.
84. Van Nieuwenhove, S., Schechter, P. J., Declercq, J., Bone, G., Burke, J. and Sjoerdsma, A. 1985. Treatment of gambiense sleeping sickness in the Sudan with Oral DFMO DL-a-difluoromethylornithine), an inhibitor of the ornithine decarboxylase; first field trial. Trans. Roy. Soc. Trop. Med. Hyg. 79, 692-698.
85. Vansterkenburg, E. L. M., Coppens, I., Wilting, J., Bos, O. J. M., Fischer, M. J. E., Janssen, L. H. M. and Opperdoes, F. R. 1993. The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action. Acta Trop. 54, 237-250.
86. Vickerman, K. 1978. Antigenic variation in trypanosomes. Nature 273, 613-617.
87. Vreysen, M. J. 2001. Principles of area-wide intergrated testse fly control using the sterile insect technique. Med. Trop. (Mars.) 61, 397-411.
88. Vreysen, M. J., Saleh, K. M., Ali, M. Y., Abdulla, A. M., Zhu, Z. R., Juma, K. G., Dyck, V. A., Msangi, A. R., Mkonyi, P. A. and Feldmann, H. U. 2000. Glossina austeni (Diptera: Glossinidae) eradicated on the island of Unguja, Zanzibar, using the sterile insect technique. J. Econ. Entomol. 93, 123-135.
89. Walsh, C., Bradley, M. and Nadeau, K. 1991. Molecular studies on trypanothione reductase, a target for anti-parasitic drugs. TIBS 16, 305-309.
90. Wang, C. C. 1995. Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis. Ann. Rev. Pharmacol. Toxicol. 35, 93-127.
91. Welburn, S. C., Coleman, P. G., Fevre, E., Maudlin, I. 2001. Sleeping sickness: a tale of two diseases. A review focussing on the contrasts between the epidemiology of T.b. rhodesiense and T. b. gambiense. Parasitol. Today 19, 19-24.
92. WHO. 1986. Epidemiology and control of African trypanosomiasis. Report of a WHO Expert Committee, WHO, Geneva. Technical Report Series 739, pp. 7.
93. Wilson, K., Berens, R. L., Sifri, C. D. and Ullman, B. 1994. Amplification of the inosinate dehydrogenase gene in Trypanosoma brucei gambiense due to an increase in chromosome copy number. J. Biol. Chem. 269, 28979-28987.
94. Witola, W. H., Inoue, N., Ohasi, K. and Onuma, M. 2004. RNA-interference silencing of the adenosine transporter gene in Trypanosoma evansi confers resistance to diminazene aceturate. Exp. Parasitol. 107, 47-57.
95. Xong, H. V., Vanhamme, L., Chamekh, M., Chimfwembe, C. E., Van Den Abbele, J., Pays, A., Van Meirvenne, N., Hamers, R., De Baetselier, P. and Pays E. 1998. A VSG expression siteassociated gene confers resistance to human serum in Trypanosoma rhodesiense. Cell, 95, 839-846.