The human serum resistance associated gene is ubiquitous and conserved in Trypanosoma brucei rhodesiense throughout East Africa

Infection, Genetics and Evolution

Volumn 1, Issue 3, 2002, Pages 207-214

  Gibson, Wendy ^a   Backhouse, Toby ^a   Griffiths, Andrew ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Human trypanosomiasis; Molecular marker; Sleeping sickness; SRA gene; Trypanolytic factor; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; VSG gene

Indexed keywords

DNA MINISATELLITE; MOLECULAR MARKER; PROTEIN SRA; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; SERUM RESISTANCE ASSOCIATED PROTEIN, TRYPANOSOMA BRUCEI;

AFRICA; AFRICAN TRYPANOSOMIASIS; ARTICLE; CONTROLLED STUDY; GENE AMPLIFICATION; GENE ISOLATION; GENE TRANSFER; GENETIC ANALYSIS; GENETIC CONSERVATION; GENETIC HETEROGENEITY; GENETIC STRAIN; GENETIC TRAIT; GENETIC TRANSFECTION; HUMAN; INFECTION; NONHUMAN; PARASITE IDENTIFICATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTOZOAL GENETICS; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA RHODESIENSE; TSETSE FLY; UGANDA; ZOONOSIS; ANIMAL; DISEASE PREDISPOSITION; GENETICS; IMMUNOLOGY; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PATHOGENICITY; VARIABLE NUMBER OF TANDEM REPEAT;

ANIMALIA; GLOSSINA (PROPER); TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOZOON;

AFRICA, EASTERN; ANIMALS; DISEASE SUSCEPTIBILITY; EVOLUTION, MOLECULAR; HUMANS; MEMBRANE GLYCOPROTEINS; MINISATELLITE REPEATS; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 0036238067     PISSN: 15671348     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-1348(02)00028-X     Document Type: Article

References (31)

1. A single locus minisatellite sequence which distinguishes between Trypanosoma brucei isolates
2. Characterization of Trypanosoma brucei isolates using genetic micro- and minisatellite markers
3. Only the serum resistant bloodstream forms of Trypanosoma brucei rhodesiense express the serum resistance associated (SRA) protein
4. The serum resistance associated (SRA) gene of Trypanosoma brucei rhodesiense encodes a VSG-like protein
5. A gene expressed only in serum-resistant variants of Trypanosoma brucei rhodesiense
6. Will the real Trypanosoma brucei gambiense please stand up?
7. Analysis of a genetic cross between Trypanosoma brucei rhodesiense and T.b. brucei
8. Molecular characterization of field isolates of human pathogenic trypanosomes
9. Isoenzyme characterisation of some Trypanozoon stocks from a recent trypanosomiasis epidemic in Uganda
10. Heritability of the trait for human infectivity in genetic crosses of Trypanosoma brucei ssp
11. Numerical analysis of enzyme polymorphism: A new approach to the epidemiology and taxonomy of trypanosomes of the subgenus Trypanosoma
12. The distribution, relationships and identification of enzymic variants within the subgenus Trypanozoon
13. The isolation of Trypanosoma rhodesiense from a bushbuck
14. Trypanosoma brucei rhodesiense: Characterisation of stocks from Zambia, Kenya, and Uganda using repetitive DNA probes
15. The origins, dynamics and generation of Trypanosoma brucei rhodesiense epidemics in East Africa
16. A new in vitro test for human serum resistance of Trypanosoma (T) brucei
17. Hybrid formation between African trypanosomes during cyclical transmission
18. Genetic diversity among Trypanosoma brucei rhodesiense isolates from Tanzania
19. A high level of mixed Trypanosoma brucei infections in tsetse flies detected by three hypervariable minisatellites
20. Minisatellite marker analysis of Trypanosoma brucei: Reconciliation of clonal, panmictic, and epidemic population genetic structures
21. Evidence for multiple origins of human infectivity in Trypanosoma brucei revealed by minisatellite variant repeat mapping
22. Expression and localisation of serum resistance associated protein in Trypanosoma brucei rhodesiense
23. The epidemiology of Trypanosoma rhodesiense sleeping sickness in Alego location. Central Nyanza, Kenya I. Evidence that cattle may act as reservoir hosts of trypanosomes infective to man
24. The epidemic spread of Rhodesian sleeping sickness 1908-1960
25. Taxonomy of the sleeping sickness trypanosomes
26. Trypanosome lytic factors novel mediators of human innate immunity
27. The testing of proven Trypanosoma brucei and T. rhodesiense strains by the blood incubation infectivity test
28. Human African trypanosomiasis in south-eastern Uganda: Clinical diversity and isoenzyme profiles
29. Enzyme variation in Trypanosoma brucei spp. II. Evidence for T.b. rhodesiense being a set of variants of T.b. brucei
30. The blood incubation infectivity test as a means of distinguishing between Trypanosoma brucei brucei and T. brucei rhodesiense
31. A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense