Microsomal prostaglandin e synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis

Neurochemistry International

Volumn 62, Issue 3, 2013, Pages 271-280

  Takeuchi, Chisen ^a,b   Matsumoto, Yoh ^c   Kohyama, Kuniko ^c   Uematsu, Satoshi ^d   Akira, Shizuo ^d   Yamagata, Kanato ^c   Takemiya, Takako ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b Kita Medical and Rehabilitation Center for Disabled   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Endothelial cell; Experimental allergic encephalomyelitis (EAE); Inflammation and demyelination; Microsomal prostaglandin synthetase 1 (mPGES 1) deficient mice; Multiple sclerosis (MS); Prostaglandin E2 (PGE2)

Indexed keywords

CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CXCR3; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROSTAGLANDIN E SYNTHASE 1;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL FEATURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DEMYELINATION; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; ENDOTHELIUM CELL; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LOCOMOTION; LUMBAR SPINAL CORD; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ANIMALS; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTRAMOLECULAR OXIDOREDUCTASES; MICE; MICE, INBRED C57BL; MICROSOMES; MULTIPLE SCLEROSIS;

ANIMALIA; MUS;

EID: 84873458993     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.12.007     Document Type: Article

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