Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy

Human Brain Mapping

Volumn 34, Issue 3, 2013, Pages 519-529

  Scahill, Rachael I ^a   Hobbs, Nicola Z ^a   Say, Miranda J ^a   Bechtel, Natalie ^b   Henley, Susie M D ^a   Hyare, Harpreet ^a   Langbehn, Douglas R ^c   Jones, Rebecca ^d   Leavitt, Blair R ^e   Roos, Raymund A C ^f   Durr, Alexandra ^g   Johnson, Hans ^c   Lehéricy, Stéphane ^g   Craufurd, David ^h   Kennard, Christopher ⁱ   Hicks, Stephen L ⁱ   Stout, Julie C ^j   Reilmann, Ralf ^b   Tabrizi, Sarah J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF IOWA   (United States)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^g INSERM   (France)

^h UNIVERSITY OF MANCHESTER   (United Kingdom)

ⁱ UNIVERSITY OF OXFORD   (United Kingdom)

^j MONASH UNIVERSITY   (Australia)

more..

Author keywords

Magnetic resonance imaging; TRACK HD; Voxel based morphometry

Indexed keywords

ADULT; AFFECT; APATHY; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; CAPSULA INTERNA; CAUDATE NUCLEUS; CLINICAL ASSESSMENT; COGNITION; CORPUS CALLOSUM; CORPUS STRIATUM; CUNEUS; DISEASE SEVERITY; EMOTION; EXTERNAL CAPSULE; EYE MOVEMENT CONTROL; FEMALE; FUSIFORM GYRUS; GAIT; HIPPOCAMPUS; HUMAN; HUNTINGTON CHOREA; INFERIOR FRONTAL GYRUS; INFERIOR PARIETAL LOBULE; INSULA; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; METRONOME TAPPING; MOTOR PERFORMANCE; MULTICENTER STUDY; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVATIONAL STUDY; OCCIPITAL LOBE; PARIETO-OCCIPITAL SULCUS; PRECUNEUS; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; PUTAMEN; RECOGNITION; SENSORIMOTOR CORTEX; SMELLING; STRIATE CORTEX; SUPERIOR TEMPORAL GYRUS; TASK PERFORMANCE; TONGUE FORCE; VOXEL BASED MORPHOMETRY; WHITE MATTER;

ADULT; ATROPHY; BRAIN; BRAIN MAPPING; COGNITION DISORDERS; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; GAIT DISORDERS, NEUROLOGIC; HUMANS; HUNTINGTON DISEASE; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OCULAR MOTILITY DISORDERS; PSYCHOMOTOR DISORDERS; TONGUE;

EID: 84873455635     PISSN: 10659471     EISSN: 10970193     Source Type: Journal    
DOI: 10.1002/hbm.21449     Document Type: Article

References (47)

1. Ashburner J ( 2007): A fast diffeomorphic image registration algorithm. Neuroimage 38: 95-113.
2. Aylward EH, Li Q, Stine OC, Ranen N, Sherr M, Barta PE, Bylsma FW, Pearlson GD, Ross CA ( 1997): Longitudinal change in basal ganglia volume in patients with Huntington's disease. Neurology 48: 394-399.
3. Aylward EH, Sparks BF, Field KM, Yallapragada V, Shpritz BD, Rosenblatt A, Brandt J, Gourley LM, Liang K, Zhou H, Margolis RL, Ross CA ( 2004): Onset and rate of striatal atrophy in preclinical Huntington disease. Neurology 63: 66-72.
4. Aylward EH, Nopoulos PC, Ross CA, Langbehn DR, Pierson RK, Mills JA, Johnson HJ, Magnotta VA, Juhl AR, Paulsen JS ( 2010): Longitudinal change in regional brain volumes in prodromal Huntington disease. J Neurol Neurosurg Psychiatry 22: 405-410.
5. Bechtel N, Scahill RI, Rosas HD, Acharya T, van den Bogaard SJ, Jauffret C, Say MJ, Sturrock A, Johnson H, Onorato CE, Salat DH, Durr A, Leavitt BR, Roos RA, Landwehrmeyer GB, Langbehn DR, Stout JC, Tabrizi SJ, Reilmann R ( 2010): Tapping linked to function and structure in premanifest and symptomatic Huntington disease. Neurology 75: 2150-2160.
6. Berrios GE, Wagle AC, Markova IS, Wagle SA, Rosser A, Hodges JR ( 2002): Psychiatric symptoms in neurologically asymptomatic Huntington's disease gene carriers: A comparison with gene negative at risk subjects. Acta Psychiatr Scand 105: 224-230.
7. Biglan KM, Ross CA, Langbehn DR, Aylward EH, Stout JC, Queller S, Carlozzi NE, Duff K, Beglinger LJ, Paulsen JS ( 2009): Motor abnormalities in premanifest persons with Huntington's disease: The PREDICT-HD study. Mov Disord 24: 1763-1772.
8. Blekher T, Johnson SA, Marshall J, White K, Hui S, Weaver M, Gray J, Yee R, Stout JC, Beristain X, Wojcieszek J, Foroud T ( 2006): Saccades in presymptomatic and early stages of Huntington disease. Neurology 67: 394-399.
9. Bohanna I, Georgiou-Karistianis N, Sritharan A, Asadi H, Johnston L, Churchyard A, Egan G ( 2011): Diffusion tensor imaging in Huntington's disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits. Brain Imaging Behav 5: 171-80.
10. Craufurd D, Thompson JC, Snowden JS ( 2001): Behavioral changes in Huntington disease. Neuropsychiatry Neuropsychol Behav Neurol 14: 219-226.
11. Duff K, Paulsen J, Mills J, Beglinger LJ, Moser DJ, Smith MM, Langbehn D, Stout J, Queller S, Harrington DL ( 2010): Mild cognitive impairment in prediagnosed Huntington disease. Neurology 75: 500-507.
12. Dumas EM, van den Bogaard SJ, Ruber ME, Reilman RR, Stout JC, Craufurd D, Hicks SL, Kennard C, Tabrizi SJ, van Buchem MA, van der Grond J, Roos RA ( 2011): Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease. Hum Brain Mapp (in press).
13. Ekman P, Friesen WV ( 1976): Pictures of Facial Affect. Palo Alto, CA: Consulting Psychologists Press.
14. Ettinger U, Ffytche DH, Kumari V, Kathmann N, Reuter B, Zelaya F, Williams SC ( 2008): Decomposing the neural correlates of antisaccade eye movements using event-related FMRI. Cereb Cortex 18: 1148-1159.
15. Freeborough PA, Fox NC, Kitney RI ( 1997): Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans. Comput Methods Programs Biomed 53: 15-25.
16. Golding CV, Danchaivijitr C, Hodgson TL, Tabrizi SJ, Kennard C ( 2006): Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology 67: 485-487.
17. Henley SM, Wild EJ, Hobbs NZ, Warren JD, Frost C, Scahill RI, Ridgway GR, Macmanus DG, Barker RA, Fox NC, Tabrizi SJ ( 2008): Defective emotion recognition in early HD is neuropsychologically and anatomically generic. Neuropsychologia 46: 2152-2160.
18. Henley SM, Wild EJ, Hobbs NZ, Frost C, MacManus DG, Barker RA, Fox NC, Tabrizi SJ ( 2009): Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease. Mov Disord 24: 932-936.
19. Hicks SL, Robert MP, Golding CV, Tabrizi SJ, Kennard C ( 2008): Oculomotor deficits indicate the progression of Huntington's disease. Prog Brain Res 171: 555-558.
20. Hobbs NZ, Henley SM, Wild EJ, Leung KK, Frost C, Barker RA, Scahill RI, Barnes J, Tabrizi SJ, Fox NC ( 2009): Automated quantification of caudate atrophy by local registration of serial MRI: Evaluation and application in Huntington's disease. Neuroimage 47: 1659-1665.
21. Huntington's Disease Study Group( 1996): Unified Huntington's disease rating scale: Reliability and consistency. Mov Disord 11: 136-142.
22. Johnson SA, Stout JC, Solomon AC, Langbehn DR, Aylward EH, Cruce CB, Ross CA, Nance M, Kayson E, Julian-Baros E, Hayden MR, Kieburtz K, Guttman M, Oakes D, Shoulson I, Beglinger L, Duff K, Penziner E, Paulsen JS ( 2007): Beyond disgust: Impaired recognition of negative emotions prior to diagnosis in Huntington's disease. Brain 130: 1732-1744.
23. Julien CL, Thompson JC, Wild S, Yardumian P, Snowden JS, Turner G, Craufurd D ( 2007): Psychiatric disorders in preclinical Huntington's disease. J Neurol Neurosurg Psychiatry 78: 939-943.
24. Kloppel S, Draganski B, Golding CV, Chu C, Nagy Z, Cook PA, Hicks SL, Kennard C, Alexander DC, Parker GJ, Tabrizi SJ, Frackowiak RS ( 2008): White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington's disease. Brain 131: 196-204.
25. Kloppel S, Draganski B, Siebner HR, Tabrizi SJ, Weiller C, Frackowiak RS ( 2009): Functional compensation of motor function in pre-symptomatic Huntington's disease. Brain 132: 1624-1632.
26. Lange H, Thorner G, Hopf A, Schroder KF ( 1976): Morphometric studies of the neuropathological changes in choreatic diseases. J Neurol Sci 28: 401-425.
27. Lasker AG, Zee DS ( 1997): Ocular motor abnormalities in Huntington's disease. Vision Res 37: 3639-3645.
28. Matell MS, Meck WH ( 2004): Cortico-striatal circuits and interval timing: Coincidence detection of oscillatory processes. Brain Res Cogn Brain Res 21: 139-170.
29. Nopoulos PC, Aylward EH, Ross CA, Johnson HJ, Magnotta VA, Juhl AR, Pierson RK, Mills J, Langbehn DR, Paulsen JS ( 2010): Cerebral cortex structure in prodromal Huntington disease. Neurobiol Dis 40: 544-554.
30. Paulsen JS, Langbehn DR, Stout JC, Aylward E, Ross CA, Nance M, Guttman M, Johnson S, MacDonald M, Beglinger LJ, Duff K, Kayson E, Biglan K, Shoulson I, Oakes D, Hayden M ( 2008): Detection of Huntington's disease decades before diagnosis: The Predict-HD study. J Neurol Neurosurg Psychiatry 79: 874-880.
31. Penney JBJr, Vonsattel JP, MacDonald ME, Gusella JF, Myers RH ( 1997): CAG repeat number governs the development rate of pathology in Huntington's disease. Ann Neurol 41: 689-692.
32. Rao AK, Muratori L, Louis ED, Moskowitz CB, Marder KS ( 2008): Spectrum of gait impairments in presymptomatic and symptomatic Huntington's disease. Mov Disord 23: 1100-1107.
33. Reilmann R, Bohlen S, Klopstock T, Bender A, Weindl A, Saemann P, Auer DP, Ringelstein EB, Lange HW ( 2010): Tongue force analysis assesses motor phenotype in premanifest and symptomatic Huntington's disease. Mov Disord 25: 2195-2202.
34. Ridgway GR, Omar R, Ourselin S, Hill DL, Warren JD, Fox NC ( 2009): Issues with threshold masking in voxel-based morphometry of atrophied brains. Neuroimage 44: 99-111.
35. Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, van der Kouwe A, Jenkins BG, Dale AM, Fischl B ( 2002): Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology 58: 695-701.
36. Rosas HD, Hevelone ND, Zaleta AK, Greve DN, Salat DH, Fischl B ( 2005): Regional cortical thinning in preclinical Huntington disease and its relationship to cognition. Neurology 65: 745-747.
37. Rosas HD, Salat DH, Lee SY, Zaleta AK, Pappu V, Fischl B, Greve D, Hevelone N, Hersch SM ( 2008): Cerebral cortex and the clinical expression of Huntington's disease: Complexity and heterogeneity. Brain 131: 1057-1068.
38. Shoulson I, Fahn S ( 1979): Huntington disease: Clinical care and evaluation. Neurology 29: 1-3.
39. Squitieri F, Cannella M, Simonelli M, Sassone J, Martino T, Venditti E, Ciammola A, Colonnese C, Frati L, Ciarmiello A ( 2009): Distinct brain volume changes correlating with clinical stage, disease progression rate, mutation size, and age at onset prediction as early biomarkers of brain atrophy in Huntington's disease. CNS Neurosci Ther 15: 1-11.
40. Starkstein SE, Mizrahi R, Capizzano AA, Acion L, Brockman S, Power BD ( 2009): Neuroimaging correlates of apathy and depression in Alzheimer's disease. J Neuropsychiatry Clin Neurosci 21: 259-265.
41. Stout JC, Paulsen JS, Queller S, Solomon AC, Whitlock KB, Campbell JC, Carlozzi N, Duff K, Beglinger LJ, Langbehn DR, Johnson SA, Biglan KM, Aylward EH ( 2011): Neurocognitive signs in prodromal Huntington disease. Neuropsychology 25: 1-14.
42. Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RA, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC, Scahill RI, Borowsky B, Tobin AJ, Rosas HD, Johnson H, Reilmann R, Landwehrmeyer B, Stout JC ( 2009): Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: Cross-sectional analysis of baseline data. Lancet Neurol 8: 791-801.
43. Tabrizi SJ, Scahill RI, Durr A, Roos RA, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H, Hicks SL, Kennard C, Craufurd D, Frost C, Langbehn DR, Reilmann R, Stout JC ( 2011): Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: The 12-month longitudinal analysis. Lancet Neurol 10: 31-42.
44. The Huntington's Disease Collaborative Research Group ( 1993): A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72: 971-983.
45. Thieben MJ, Duggins AJ, Good CD, Gomes L, Mahant N, Richards F, McCusker E, Frackowiak RS ( 2002): The distribution of structural neuropathology in pre-clinical Huntington's disease. Brain 125: 1815-1828.
46. Whitwell JL, Crum WR, Watt HC, Fox NC ( 2001): Normalization of cerebral volumes by use of intracranial volume: Implications for longitudinal quantitative MR imaging. AJNR 22: 1483-1489.
47. Wiener M, Turkeltaub P, Coslett HB ( 2010): The image of time: A voxel-wise meta-analysis. Neuroimage 49: 1728-1740.