Low dose BMP-2 treatment for bone repair using a PEGylated fibrinogen hydrogel matrix

Biomaterials

Volumn 34, Issue 12, 2013, Pages 2902-2910

  Ben David, Dror ^a   Srouji, Samer ^a   Shapira Schweitzer, Keren ^a   Kossover, Olga ^a   Ivanir, Eran ^a   Kuhn, Gisela ^b   Müller, Ralph ^b   Seliktar, Dror ^a   Livne, Erella ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b ETH ZURICH   (Switzerland)

Author keywords

Contrast agents; Fluorescence imaging; Hydrogel; MicroCT; Polyethylene glycol; Tissue regeneration

Indexed keywords

BONE DEFECT; BONE DEFECT MODELS; BONE FORMATION; BONE MORPHOGENIC PROTEIN; BONE REPAIR; CALVARIAL DEFECTS; CLINICAL OUTCOME; CONTRAST AGENT; CONTROL DEFECTS; CRITICAL SIZE; DELIVERY SYSTEMS; FLUORESCENCE IMAGING; GROWTH FACTOR; HIGH DOSE; HOST TISSUES; HYDROGEL MATRIX; IMPLANTATION MODELS; IN-VITRO ASSAYS; LOW DOSE; MICRO CT; OSTEOCONDUCTIVE; PHYSIOLOGICAL DOSE; REPAIR TISSUES; RESORBABLE; TISSUE REGENERATION;

BIOACTIVITY; BIODEGRADATION; BONE; COMPUTERIZED TOMOGRAPHY; DEFECTS; HYDROGELS; POLYETHYLENE GLYCOLS; TISSUE;

BIOMATERIALS;

BIOMATERIAL; FIBRINOGEN; PEGYLATED FIBRINOGEN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADATION; BIOLOGICAL ACTIVITY; BONE DEFECT; BONE REMODELING; BONE TISSUE; CALVARIA; CONTROLLED STUDY; DRUG RELEASE; FEASIBILITY STUDY; HYDROGEL; IMPLANTATION; IN VITRO STUDY; LOW DRUG DOSE; MAXILLOFACIAL DISORDER; MOUSE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; TISSUE REGENERATION;

ANIMALS; BONE DEVELOPMENT; BONE MORPHOGENETIC PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRINOGEN; HYDROGELS; MICE; MICE, NUDE; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; TOMOGRAPHY, X-RAY COMPUTED;

MUS; RATTUS;

EID: 84873449904     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.01.035     Document Type: Article

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