Triazolam and zolpidem: A comparison of their psychomotor, cognitive, and subjective effects in healthy volunteers

Behavioural Pharmacology

Volumn 8, Issue 6-7, 1997, Pages 561-574

  Mintzer, M Z ^a   Frey, J M ^a,b   Yingling, J E ^a   Griffiths, R R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Astra Merck   (United States)

Author keywords

Benzodiazepines; Cognitive; Human; Memory; Psychomotor; Subjective; Triazolam; Zolpidem

Indexed keywords

BENZODIAZEPINE DERIVATIVE; TRIAZOLAM; ZOLPIDEM;

ADULT; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PSYCHOMOTOR PERFORMANCE;

EID: 0030780231     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-199711000-00014     Document Type: Article

References (57)

1. Balkin T, O'Donnell V, Wesensten N, McCann U and Belenky G (1992) Comparison of the daytime sleep and performance effects of zolpidem versus triazolam. Psychopharmacology, 107, 83-88.
2. 3H]flumazenil binding in the rat CNS. Journal of Pharmacology and Experimental Therapeutics, 263, 884-896.
3. Benavides J, Peny B, Ruano D, Vitorica J and Scatton B (1993) Comparative autoradiographic distribution of central ω (benzodiazepine) modulatory site subtypes with high, intermediate, and low affinity for zolpidem and alpidem. Brain Research, 604, 240-250.
4. Berlin I, Warot D, Hergueta T, Molinier P, Bagot C and Puech AJ (1993) Comparison of the effects of zolpidem and triazolam on memory functions, psychomotor performances, and postural sway in healthy subjects. Journal of Clinical Psychopharmacology, 13, 100-106.
5. Biggio G, Concas A, Corda M and Serra M (1989) Enhancement of GABAergic transmission by zolpidem, an imidazopyridine with preferential affinity for type I benzodiazepine receptors (1989) European Journal of Pharmacology, 161, 173-180.
6. Chodera A, Nowakowska E and Bartczak G (1994) Tolerance to a new class of non-benzodiazepine anxiolytics. Polish Journal of Pharmacology, 46, 479-481.
7. Cohen C and Sanger DJ (1994) Tolerance, cross-tolerance and dependence measured by operant responding in rats treated with triazolam via osmotic pumps. Psychopharmacology, 115, 86-94.
8. Cooper SJ and Desa A (1988) Pyrazoloquiolines and zolpidem: effects on hypertonic saline consumption in rehydrating rats. Drug Development Research, 14, 161-168.
9. Cox A, Boyland P, Gent JP and Feely M (1988) An investigation of anticonvulsant tolerance to zolpidem in mice. British Journal of Pharmacology, 95, 667P.
10. Davies MF, Onaivi ES, Chen SW, Maguire PA, Tsai NF and Loew GH (1994) Evidence for central benzodiazepine receptor heterogeneity from behavior tests. Pharmacology, Biochemistry and Behavior, 49, 47-56.
11. Depoortere H, Zivkovic B, Lloyd KG, Sanger DJ, Perrault G, Langer SZ and Bartholini G (1986) Zolpidem, a novel non-benzodiazepine hypnotic. I. Neuropharmacological and behavioral effects. Journal of Pharmacology and Experimental Therapeutics, 237, 649-658.
12. 3H]zolpidem binding sites in relation to messenger RNA encoding the alpha 1, beta 2 and gamma 2 subunits of GABAA receptors in rat brain. Neuroscience, 64, 1113-1128.
13. Evans S, Funderburk F and Griffiths RR (1990) Zolpidem and triazolam in humans: behavioral and subjective effects and abuse liability. Journal of Pharmacology and Experimental Therapeutics, 255, 1246-1255.
14. Fernandez-Guardiola A, Jurado JL and Aguilar-Jimenez E (1984) Evaluation of the attention and sleepiness states by means of a psychophysiological test of reaction time and time estimate in man: effect of psychotropic drugs. Current Therapeutic Research, 35, 1000-1009.
15. Fortin C and Breton R (1995) Temporal interval production and processing in working memory. Perception and Psychophysics, 57, 203-215.
16. Ghoneim MM, Hinrichs JV and Mewaldt SP (1984) Dose-response analysis of the behavioral effects of diazepam: I. Learning and memory. Psychopharmacology, 82, 291-295.
17. Griffiths RR, Bigelow G and Liebson I (1983) Differential effects of diazepam and pentobarbital on mood and behavior. Archives of General Psychiatry, 40, 865-873.
18. Griffiths RR, Lamb RJ, Sannerud CA, Ator NA and Brady JV (1991) Self-injection of barbiturates, benzodiazepines and other sedative-anxiolytics in baboons. Psychopharmacology, 103, 154-161.
19. Griffiths RR, Sannerud CA, Ator NA and Brady JV (1992) Zolpidem behavioral pharmacology in baboons: self-injection, discrimination, tolerance and withdrawal. Journal of Pharmacology and Experimental Therapeutics, 260, 1199-1208.
20. Halstead WC (1947) Brain and Intelligence. University of Chicago Press, Chicago.
21. Jasinski DR (1977) Assessment of the abuse potentiality of morphine-like drugs (methods used in man). In: Drug Addiction I (Ed WR Martin), pp. 197-258. Springer-Verlag, New York.
22. Kirk T, Roache JD and Griffiths RR (1990) Dose-response evaluation of the amnestic effects of triazolam and pentobarbital in normal subjects. Journal of Clinical Psychopharmacology, 10, 160-167.
23. Kucera H and Francis WN (1967) Computational Analysis of Present-day American English. Brown University Press, Providence.
24. Lapp WM, Collins, RL, Zywiak WH and Izzo CV (1994) Psychopharmacological effects of alcohol on time perception: the extended balanced placebo design. Journal of Studies on Alcohol, 55, 96-112.
25. Lukas SE and Griffiths RR (1982) Precipitated withdrawal by a benzodiazepine receptor antagonist (Ro 15-1788) after 7 days of diazepam. Science, 217, 1161-1163.
26. Martin WR, Sloan JW, Sapiro JD and Jasinski DR (1971) Physiologic, subjective and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine and methylphenidate in man. Clinical Pharmacology and Therapeutics, 12, 245-258.
27. McLeod DR, Griffiths RR, Bigelow GE and Yingling J (1982) An automated version of the digit symbol substitution test (DSST). Behavioral Research Methods and Instrumentation, 14, 463-466.
28. Parker ES and Weingartner H (1984) Retrograde facilitation of human memory by drugs. In: Memory Consolidation: Psychobiology of Cognition (Eds H Weingartner and ES Parker), pp. 231-247. Erlbaum, Hillsdale.
29. Perrault G, Morel E, Sanger DJ and Zivkovic B (1990) Differences in pharmacological profiles of a new generation of benzodiazepine and non-benzodiazepine hypnotics. European Journal of Pharmacology, 187, 487-494.
30. Perrault G, Morel E, Sanger DJ and Zivkovic B (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. Journal of Pharmacology and Experimental Therapeutics, 263, 298-303.
31. Rammasayer T (1995) Extraversion and alcohol: Eysenck's drug postulate revisited. Neuropsychobiology, 32, 197-207.
32. Reitan RM (1955a) Investigation of the validity of Halstead's measure of biological intelligence. Archives of Neurology and Psychiatry, 73, 28-35.
33. Reitan RM (1955b) The relation of the Trail Making Test to organic brain damage. Journal of General Psychology, 53, 97-107.
34. Reitan RM (1958) The validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271-276.
35. Roehrs T, Merlotti L, Zorick F and Roth T (1994) Sedative, memory, and performance effects of hypnotics. Psychopharmacology, 116, 130-134.
36. Rowlett JK and Woolverton WL (1997) Discriminative stimulus effects of zolpidem in pentobarbital-trained subjects: I. Comparison with triazolam in rhesus monkeys and rats. The Journal of Pharmacology and Experimental Therapeutics, 280, 162-173.
37. Rush CR and Griffiths RR (1996) Zolpidem, triazolam, and temazepam: behavioral and subject-rated effects in normal volunteers. Journal of Clinical Psychopharmacology, 16, 146-157.
38. Rush CR, Madakasira S, Goldman NH, Woolverton WL and Rowlett JK (1997). Discriminative stimulus effects of zolpidem in pentobarbital-trained subject. II. Comparison with triazolam and caffeine in humans. The Journal of Pharmacology and Experimental Therapeutics, 280, 174-188.
39. Salva P and Costa J (1995) Clinical pharmacokinetics and pharmacodynamics of zolpidem: therapeutic implications. Clinical Pharmacokinetics, 29, 142-153.
40. Sanger DJ (1987) Further investigation of the stimulus properties of chlordiazepoxide and zolpidem. Agonism and antagonism by two novel benzodiazepines. Psychopharmacology, 93, 365-368.
41. Sanger DJ (1995) Behavioral effects of novel benzodiazepine (ω) receptor agonists and partial agonists: Increases in punished responding and antagonism of the pentylenetetrazole cue. Behavioural Pharmacology, 6, 116-126.
42. 3H]-flumazenil binding in different regions of the rat central nervous system. Psychopharmacology, 111, 315-322.
43. Sanger DJ and Zivkovic B (1987) Discriminative stimulus properties of chlordiazepoxide and zolpidem. Agonist and antagonist effects of CGS 9896 and ZK 91296. Neuropharmacology, 26, 499-505.
44. Sanger DJ and Zivkovic B (1988) Further behavioural evidence for the selective sedative action of zolpidem. Neuropharmacology, 27, 1125-1130.
45. Sanger DJ and Zivkovic B (1992) Differential development of tolerance to the depressant effects of benzodiazepine and non-benzodiazepine agonists at the omega (BZ) modulatory sites of GABAA receptors. Neuropharmacology, 31, 693-700.
46. Sanger DJ, Joly D and Zivkovic B (1986) Effects of zolpidem, a new imidazopyridine hypnotic, on the acquisition of conditioned fear in mice. Comparison with triazolam and CL 218,872. Psychopharmacology, 90, 207-210.
47. Sanger DJ, Perrault G, Morel E, Joly D and Zivkovic B (1987) The behavioral profile of zolpidem, a novel hypnotic drug of imidazopyridine structure. Physiology and Behavior, 41, 235-240.
48. Sannerud C, Cook J and Griffiths RR (1989) Behavioral differentiation of benzodiazepine ligands after repeated administration in baboons. European Journal of Pharmacology, 167, 333-343.
49. Sauvanet JP, Maarek L, Roger M, Renaudin AJ, Louvel E and Orofiamma B (1988) Open long-term trials with zolpidem in insomnia. In: Imidazopyridines in Sleep Disorders (Eds JP Sauvanet, SZ Langer and PL Morselli), pp. 339-349. Raven Press, New York.
50. Schmid L, Bottlaender M, Fuseau C, Fournier D, Brouillet E and Maziere M (1995) Zolpidem displays heterogeneity in its binding to the nonhuman primate benzodiazepine receptor in vivo. Journal of Neurochemistry, 65, 1880-1886.
51. Stanhope KJ, Roe S, Dawson G, Draper F and Jackson A (1993) Effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid consumption in the rat. Psychopharmacology, 111, 185-189.
52. Thenot JP, Herman P, Durand A, Burke JT, Allen J, Garrigou D, Vajta S, Albin H, Thebault JJ, Olive G and Warrington SJ (1988) Pharmacokinetics and metabolism of zolpidem in various animal species and in humans. In: Imidazopyridines in Sleep Disorders (Eds JP Sauvanet, SZ Langer and PL Morselli), pp. 139-153. Raven Press, New York.
53. VonVoigtlander PF and Lewis RA (1991) A rapid screening method for the assessment of benzodiazepine receptor-related physical dependence in mice: evaluation of benzodiazepine-related agonists and partial agonists. Journal of Pharmacological Methods, 26, 1-5.
54. Unrug-Neervoort A, Kaiser J, Coenen A (1992) Influence of diazepam on prospective time estimation. Perceptual and Motor Skills, 75, 993-994.
55. Weingartner HJ, Sirocco K, Curran V and Wolkowitz O (1995) Memory facilitation following the administration of the benzodiazepine triazolam. Experimental and Clinical Psychopharmacology, 3, 298-303.
56. Wittenborn JR, Flaherty CF, Hamilton LW, Schiffman HR and McGough WE (1976) The effect of minor tranquilizers on psychomotor performance. Psychopharmacology, 47, 281-286.
57. Yerbury RE and Cooper SJ (1989) Novel benzodiazepine receptor ligands: palatable food intake following zolpidem, CGS 17867A, or Ro23-0364, in the rat. Pharmacology Biochemistry and Behavior, 33, 303-307.