Vasodilatory effects of cinnamic acid via the nitric oxide-cGMP-PKG pathway in rat thoracic aorta

Phytotherapy Research

Volumn 27, Issue 2, 2013, Pages 205-211

  Kang, Yun Hwan ^a   Kang, Jae Sook ^a   Shin, Heung Mook ^a  

^a Dongguk University   (South Korea)

Author keywords

Ca2+ activated K+ channel; cGMP dependent protein kinase (PKG); cinnamic acid; cyclic guanosine monophosphate (cGMP); nitric oxide

Indexed keywords

CINNAMIC ACID; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; KT 5823; METHYLENE BLUE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRITE; PHENYLEPHRINE; TETRYLAMMONIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM; HUMAN; HUMAN CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; THORACIC AORTA; UMBILICAL VEIN ENDOTHELIAL CELL; VASODILATATION; WESTERN BLOTTING;

ANIMALS; AORTA, THORACIC; CINNAMATES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENDOTHELIUM; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION; VASODILATOR AGENTS;

RATTUS;

EID: 84873412672     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4708     Document Type: Article

References (34)

1. Bickers D, Calow P, Greim H, et al. 2005. A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients. Food Chem Toxicol 43: 799-836.
2. Browner NC, Dey NB, Bloch KD, Lincoln TM,. 2004. Regulation of cGMP-dependent protein kinase expression by soluble guanylyl cyclase in vascular smooth muscle cells. J Biol Chem 279: 46631-46636.
3. Chatterjee A, Black SM, Catravas JD,. 2008. Endothelial nitric oxide (NO) and its pathophysiologic regulation. Vascul Pharmacol 49: 134-140.
4. Chen ZP, Mitchelhill KI, Michell BJ, et al. 1999. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett 443: 285-289.
5. Chu DM, Corbin JD, Grimes KA, Francis SH,. 1997. Activation by cyclic GMP binding causes an apparent conformational change in cGMP-dependent protein kinase. J Biol Chem 272: 31922-31628.
6. Félétou M, Köhler R, Vanhoutte PM,. 2010. Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets. Curr Hypertens Rep 12: 267-275.
7. Fleming I, Busse R,. 2003. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 284: R1-R12.
8. Furchgott RF, Cherry PD, Zawadzki JV, Jothianandan D,. 1984. Endothelial cells as mediators of vasodilation of arteries. J Cardiovasc Pharmacol 6: S336-S343.
9. Garrait G, Jarrige JF, Blanquet S, Beyssac E, Cardot JM, Alric M,. 2006. Gastrointestinal absorption and urinary excretion of trans-cinnamic and p-coumaric acids in rats. J Agric Food Chem 54: 2944-2950.
10. He ZD, Qiao CF, Han QB, et al. 2005. Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography. J Agric Food Chem 53: 2424-2428.
11. Horowitz A, Menice CB, Laporte R, Morgan KG,. 1996. Mechanisms of smooth muscle contraction. Physiol Rev 76: 967-1003.
12. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G,. 1987. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84: 9265-9269.
13. Ignarro LJ, Cirino G, Casini A, Napoli C,. 1999. Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol 34: 879-886.
14. Jeon SB, Kim G, Kim JI, et al. 2007. Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit. Clin Exp Pharmacol Physiol 34: 1116-1120.
15. 2+ channel blockage. Kor J Ori Med Phywiol Pathol 24: 592-597.
16. Lee DL, Webb RC, Jin L,. 2004. Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature. Hypertension 44: 796-799.
17. Leeb-Lundberg LM, Mathis SA, Herzig MC,. 1994. Antagonists of bradykinin that stabilize a G-protein-uncoupled state of the B2 receptor act as inverse agonists in rat myometrial cells. J Biol Chem 269: 25970-25973.
18. Lenasi H, Kohlstedt K, Fichtlscherer B, Mülsch A, Busse R, Fleming I,. 2003. Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495. Cardiovasc Res 59: 844-853.
19. Letizia CS, Cocchiara J, Lapczynski A, Lalko J, Api AM,. 2005. Fragrance material review on cinnamic acid. Food Chem Toxicol 43: 925-943.
20. Lincoln TM, Dey N, Sellak H,. 2001. Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression. J Appl Physiol 91: 1421-1430.
21. Liu L, Hudgins WR, Shack S, Yin MQ, Samid D,. 1995. Cinnamic acid: a natural product with potential use in cancer intervention. Int J Cancer 62: 345-350.
22. Lucas KA, Pitari GM, Kazerounian S, et al. 2000. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev 52: 375-414.
23. Natella F, Nardini M, Di Felice M, Scaccini C,. 1999. Benzoic and cinnamic acid derivatives as antioxidants: structure-activity relation. J Agric Food Chem 47: 1453-1459.
24. Olasupo NA, Fitzgerald DJ, Gasson MJ, Narbad A,. 2003. Activity of natural antimicrobial compounds against Escherichia coli and Salmonella enterica serovar Typhimurium. Lett Appl Microbiol 37: 448-451.
25. Palmer RM, Ferrige AG, Moncada S,. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524-526.
26. Prieto D,. 2008. Physiological regulation of penile arteries and veins. Int J Impot Res 20: 17-29.
27. Priviero FB, Webb RC,. 2010. Heme-dependent and independent soluble guanylate cyclase activators and vasodilation. J Cardiovasc Pharmacol 56: 229-233.
28. Schlossmann J, Ammendola A, Ashman K, et al. 2000. Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Nature 404: 197-201.
29. Surks HK,. 2007. cGMP-dependent protein kinase I and smooth muscle relaxation: a tale of two isoforms. Circ Res 101: 1078-1080.
30. Surks HK, Mochizuki N, Kasai Y, et al. 1999. Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase Ialpha. Science 286: 1583-1587.
31. Tawata S, Taira S, Kobamoto N, Zhu J, Ishihara M, Toyama S,. 1996. Synthesis and antifungal activity of cinnamic acid esters. Biosci Biotechnol Biochem 60: 909-910.
32. Word RA, Cornwell TL,. 1998. Regulation of cGMP-induced relaxation and cGMP-dependent protein kinase in rat myometrium during pregnancy. Am J Physiol 274: C748-C756.
33. Yanaga A, Goto H, Nakagawa T, Hikiami H, Shibahara N, Shimada Y,. 2006. Cinnamaldehyde induces endothelium-dependent and endothelium-independent vasorelaxant action on isolated rat aorta. Biol Pharm Bull 29: 2415-2418.
34. Zweier JL, Li H, Samouilov A, Liu X,. 2010. Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall. Nitric Oxide 22: 83-90.