PHLPP1 gene deletion protects the brain from ischemic injury

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 2, 2013, Pages 196-204

  Chen, Bo ^a   Van Winkle, Jessica A ^a   Lyden, Patrick D ^a   Brown, Joan H ^b   Purcell, Nicole H ^b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Akt; ischemia; middle cerebral artery occlusion (MCAO); PH domain leucine rich repeat protein phosphatase (PHLPP); stroke

Indexed keywords

OXYGEN; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE; GENE DELETION; IN VIVO STUDY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PH DOMAIN LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 1 GENE; PRIORITY JOURNAL; REPERFUSION;

ANIMALS; ASTROCYTES; BRAIN INFARCTION; BRAIN INJURIES; ENZYME ACTIVATION; GENE DELETION; GLUCOSE; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; OXYGEN; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84873411704     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.150     Document Type: Article

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