Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt

Journal of Biological Chemistry

Volumn 286, Issue 22, 2011, Pages 19777-19788

  Warfel, Noel A ^a   Niederst, Matt ^a   Stevens, Michael W ^a   Brennan, Paul M ^b   Frame, Margaret C ^b   Newton, Alexandra C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASTROCYTOMA; ASTROCYTOMA CELLS; BRAIN TISSUE; CELLULAR LEVELS; CELLULAR LOCALIZATION; CYTOSOLS; E3 LIGASE; FEED-BACK LOOP; GLIOBLASTOMA CELLS; GLIOBLASTOMAS; GROWTH FACTOR; LEUCINE-RICH REPEATS; MISLOCALIZATION; NEGATIVE FEEDBACK; NEGATIVE FEEDBACK LOOP; NEUROSPHERES; OVER-EXPRESSION; PLECKSTRIN HOMOLOGY DOMAINS; PROTEIN PHOSPHATASE; PROTEIN PHOSPHATASE-1; TRANSDUCIN;

AMINO ACIDS; CELL CULTURE; DEFECTS; PHOSPHATASES; PROTEINS; SUBSTRATES; TISSUE;

FEEDBACK;

BETA CATENIN; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN 1; PHOSPHOPROTEIN PHOSPHATASE; PLECKSTRIN HOMOLOGY DOMAIN LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 1; PROTEIN KINASE B; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTOMA; CANCER CELL CULTURE; CANCER GRADING; CELL NUCLEUS; CELL SPECIFICITY; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; ENZYME LOCALIZATION; ENZYME REGULATION; ENZYME STABILITY; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; NEGATIVE FEEDBACK; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ACTIVE TRANSPORT, CELL NUCLEUS; BETA CATENIN; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; ENZYME STABILITY; GLIOBLASTOMA; HUMANS; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PROTO-ONCOGENE PROTEINS C-AKT; UBIQUITIN-PROTEIN LIGASES;

EID: 79957620642     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.237081     Document Type: Article

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