Evaluation of intestinal absorption of amtolmetin guacyl in rats: Breast cancer resistant protein as a primary barrier of oral bioavailability

Life Sciences

Volumn 92, Issue 3, 2013, Pages 245-251

  Rong, Zhihui ^a   Xu, Yanjiao ^a   Zhang, Chengliang ^a   Xiang, Daochun ^a   Li, Xiping ^a   Liu, Dong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Amtolmetin guacyl; Efflux transporter; Everted gut sacs; Intestinal absorption; Single pass perfusion

Indexed keywords

1,2,3,4,6,7,12,12A OCTAHYDRO 6 ISOBUTYL 9 METHOXY 1,4 DIOXOPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 3 PROPANOIC ACID TERT BUTYL ESTER; AMTOLMETIN GUACIL; BREAST CANCER RESISTANCE PROTEIN; LACTATE DEHYDROGENASE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; TOLMETIN; TOLMETIN GLYCINAMIDE; VERAPAMIL; VERLUKAST;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COLON; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG STABILITY; DRUG TRANSPORT; GENE INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ILEUM; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE CELL; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; INTESTINE PERFUSION; INTESTINE WALL; JEJUNUM; KNOCKOUT MOUSE; LIMIT OF DETECTION; MALE; NONHUMAN; RAT; STOMACH WALL;

ADENOSINE; ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL AVAILABILITY; GLYCINE; INTESTINAL ABSORPTION; INTESTINES; LEUKOTRIENE ANTAGONISTS; MALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; PROPIONATES; PYRROLES; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; TOLMETIN; VASODILATOR AGENTS; VERAPAMIL;

MUS; RATTUS;

EID: 84873407983     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.12.010     Document Type: Article

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