Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition

Neuropharmacology

Volumn 67, Issue , 2013, Pages 37-45

  Mohr, Franziska ^a   Zimmermann, Martina ^a   Klein, Jochen ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Cholinergic deficits; Donepezil; Glucose

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINE; CHOLINE ACETYLTRANSFERASE; CHOLINESTERASE; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CHOLINERGIC SYSTEM; COGNITION; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; MICRODIALYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STRAIN DIFFERENCE; WILD TYPE;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; HETEROZYGOTE; HETEROZYGOTE DETECTION; HIPPOCAMPUS; MICE; TERBUTALINE;

EID: 84873401349     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.11.001     Document Type: Article

References (60)

1. C. Andres, S. Seidman, R. Beeri, R. Timberg, and H. Soreq Transgenic acetylcholinesterase induces enlargement of murine neuromuscular junctions but leaves spinal cord synapses intact Neurochem. Int. 32 1998 449 456
2. T. Arendt, V. Bigl, A. Tennstedt, and A. Arendt Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in Alzheimer's disease Neuroscience 14 1985 1 14
3. L.M. Bierer, V. Haroutunian, S. Gabriel, P.J. Knott, L.S. Carlin, D.P. Purohit, D.P. Perl, J. Schmeidler, P. Kanof, and K.L. Davis Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits J. Neurochem. 64 1995 749 760
4. G. Bissette, F.J. Seidler, C.B. Nemeroff, and T.A. Slotkin High affinity choline transporter status in Alzheimer's disease tissue from rapid autopsy Ann. N.Y. Acad. Sci. 777 1996 197 204
5. S.A. Black, F.M. Ribeiro, S.S. Ferguson, and R.J. Rylett Rapid, transient effects of the protein kinase C activator phorbol 12-myristate 13-acetate on activity and trafficking of the rat high-affinity choline transporter Neuroscience 167 2010 765 773
6. N.I. Bohnen, D.I. Kaufer, R. Hendrickson, L.S. Ivanco, B.J. Lopresti, R.A. Koeppe, C.C. Meltzer, G. Constantine, J.G. Davis, C.A. Mathis, S.T. Dekosky, and R.Y. Moore Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease J. Neurol. Neurosurg. Psychiatry 76 2005 315 319
7. C.E. Bond, M. Zimmermann, and S.A. Greenfield Upregulation of alpha7 nicotinic receptors by acetylcholinesterase C-terminal peptides PLoS One 4 2009 e4846
8. A. Burns, A. Yeates, L. Akintade, M. Del Valle, R.Y. Zhang, E.M. Schwam, and C.A. Perdomo Defining treatment response to donepezil in Alzheimer's disease: responder analysis of patient-level data from randomized, placebo-controlled studies Drugs Aging 25 2008 707 714
9. S. Camp, L. Zhang, E. Krejci, A. Dobbertin, V. Bernard, E. Girard, E.G. Duysen, O. Lockridge, A. De Jaco, and P. Taylor Contributions of selective knockout studies to understanding cholinesterase disposition and function Chem. Biol. Interact. 187 2010 72 77
10. D. Casper, and P. Davies Stimulation of choline acetyltransferase activity by retinoic acid and sodium butyrate in a cultured human neuroblastoma Brain Res. 478 1989 74 84
11. F. Cerbai, M.G. Giovannini, C. Melani, A. Enz, and G. Pepeu N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine Eur. J. Pharmacol. 572 2007 142 150
12. C. Courtney, D. Farrell, R. Gray, R. Hills, L. Lynch, E. Sellwood, S. Edwards, W. Hardyman, J. Raftery, P. Crome, C. Lendon, H. Shaw, and P. Bentham Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial Lancet 363 2004 2105 2115
13. J.T. Coyle, D.L. Price, and M.R. DeLong Alzheimer's disease: a disorder of cortical cholinergic innervation Science 219 1983 1184 1190
14. J.L. Cummings, and C. Back The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer's disease Am. J. Geriatr. Psychiatry 6 1998 S64 S78
15. G.L. Ellman, K.D. Courtney, V.J. Andres, and R.M. Feather-Stone A new and rapid colorimetric determination of acetylcholinesterase activity Biochem. Pharmacol. 7 1961 88 95
16. C. Erb, J. Troost, S. Kopf, U. Schmitt, K. Loffelholz, H. Soreq, and J. Klein Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase J. Neurochem. 77 2001 638 646
17. V. Farar, F. Mohr, M. Legrand, D.B. Lamotte, J. Cendelin, J. Leroy, M. Abitbol, V. Bernard, F. Baud, V. Fournet, P. Houze, J. Klein, B. Plaud, J. Tuma, M. Zimmermann, P. Ascher, A. Hrabovska, J. Myslivecek, and E. Krejci Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase J. Neurochem. 122 2012 1065 1080
18. C. Geula, and M.M. Mesulam Cholinergic systems and related neuropathological predilections patterns in Alzheimer disease R.D. Terry, R. Katzman, K.L. Bick, Alzheimer Disease 1994 Raven Press New York 263 291
19. E. Giacobini Cholinesterases: new roles in brain function and in Alzheimer's disease Neurochem. Res. 28 2003 515 522
20. E. Giacobini Cholinesterase inhibitors: new roles and therapeutic alternatives Pharmacol. Res. 50 2004 433 440
21. M.G. Giovannini, C. Scali, L. Bartolini, B. Schmidt, and G. Pepeu Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats Eur. J. Pharmacol. 354 1998 17 24
22. R. Härtl, A. Gleinich, and M. Zimmermann Dramatic increase in readthrough acetylcholinesterase in a cellular model of oxidative stress J. Neurochem. 116 2011 1088 1096
23. J. Hartmann, C. Kiewert, E.G. Duysen, O. Lockridge, N.H. Greig, and J. Klein Excessive hippocampal acetylcholine levels in acetylcholinesterase- deficient mice are moderated by butyrylcholinesterase activity J. Neurochem. 100 2007 1421 1429
24. N. Hirono, M. Hashimoto, K. Ishii, H. Kazui, and E. Mori One-year change in cerebral glucose metabolism in patients with Alzheimer's disease J. Neuropsychiatry Clin. Neurosci. 16 2004 488 492
25. P. Kasa, H. Papp, P. Kasa Jr., and I. Torok Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain Neuroscience 101 2000 89 100
26. J. Klein Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids J. Neural Transm. 107 2000 1027 1063
27. S.R. Kopf, M.L. Buchholzer, M. Hilgert, K. Loffelholz, and J. Klein Glucose plus choline improve passive avoidance behaviour and increase hippocampal acetylcholine release in mice Neuroscience 103 2001 365 371
28. T. Kosasa, Y. Kuriya, K. Matsui, and Y. Yamanishi Inhibitory effects of donepezil hydrochloride (E2020) on cholinesterase activity in brain and peripheral tissues of young and aged rats Eur. J. Pharmacol. 386 1999 7 13
29. D.E. Kuhl, R.A. Koeppe, S.E. Snyder, S. Minoshima, K.A. Frey, and M.R. Kilbourn In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses Ann. Neurol. 59 2006 13 20
30. D.K. Lahiri, M.R. Farlow, K. Sambamurti, N.H. Greig, E. Giacobini, and L.S. Schneider A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease Curr. Drug Targets 4 2003 97 112
31. B. Li, J.A. Stribley, A. Ticu, W. Xie, L.M. Schopfer, P. Hammond, S. Brimijoin, S.H. Hinrichs, and O. Lockridge Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse J. Neurochem. 75 2000 1320 1331
32. G. Li, A. Gleinich, H. Lau, and M. Zimmermann Staurosporine-induced apoptosis presents with unexpected cholinergic effects in a differentiated neuroblastoma cell line Neurochem. Int. 2012 10.1016/j.neuint.2012.07.018
33. A. Mathur, A. Shandarin, S.R. LaViolette, J. Parker, and J.S. Yeomans Locomotion and stereotypy induced by scopolamine: contributions of muscarinic receptors near the pedunculopontine tegmental nucleus Brain Res. 775 1997 144 155
34. R. Mayeux Clinical practice. Early Alzheimer's disease N. Engl. J. Med. 362 2010 2194 2201
35. M.M. Mesulam, A. Guillozet, P. Shaw, A. Levey, E.G. Duysen, and O. Lockridge Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine Neuroscience 110 2002 627 639
36. E.J. Mufson, S.E. Counts, S.E. Perez, and S.D. Ginsberg Cholinergic system during the progression of Alzheimer's disease: therapeutic implications Expert Rev. Neurother. 8 2008 1703 1718
37. A.P. Passmore, A.J. Bayer, and E. Steinhagen-Thiessen Cognitive, global, and functional benefits of donepezil in Alzheimer's disease and vascular dementia: results from large-scale clinical trials J. Neurol. Sci. 229-230 2005 141 146
38. E.K. Perry, R.H. Perry, G. Blessed, and B.E. Tomlinson Changes in brain cholinesterases in senile dementia of Alzheimer type Neuropathol. Appl. Neurobiol. 4 1978 273 277
39. M. Persike, M. Zimmermann, J. Klein, and M. Karas Quantitative determination of acetylcholine and choline in microdialysis samples by MALDI-TOF MS Anal. Chem. 82 2010 922 929
40. C.M. Persson, A.K. Wallin, S. Levander, and L. Minthon Changes in cognitive domains during three years in patients with Alzheimer's disease treated with donepezil BMC Neurol. 9 2009 7
41. M. Racchi, M. Mazzucchelli, E. Porrello, C. Lanni, and S. Govoni Acetylcholinesterase inhibitors: novel activities of old molecules Pharmacol. Res. 50 2004 441 451
42. M. Racchi, E. Porrello, C. Lanni, S.C. Lenzken, M. Mazzucchelli, and S. Govoni Role of acetylcholinesterase inhibitors in pharmacological regulation of amyloid precursor protein processing Aging Clin. Exp. Res. 18 2006 149 152
43. M.W. Riepe Cholinergic treatment: what are the early neuropathological targets? Eur. J. Neurol. 12 Suppl. 3 2005 3 9
44. G.C. Roman, D.G. Wilkinson, R.S. Doody, S.E. Black, S.P. Salloway, and R.J. Schindler Donepezil in vascular dementia: combined analysis of two large-scale clinical trials Dement. Geriatr. Cogn. Disord. 20 2005 338 344
45. C. Scali, F. Casamenti, A. Bellucci, C. Costagli, B. Schmidt, and G. Pepeu Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats J. Neural Transm. 109 2002 1067 1080
46. R. Schliebs, and T. Arendt The cholinergic system in aging and neuronal degeneration Behav. Brain Res. 221 2011 555 563
47. H. Shinotoh, H. Namba, K. Fukushi, S. Nagatsuka, N. Tanaka, A. Aotsuka, T. Ota, S. Tanada, and T. Irie Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: a positron emission tomography study Ann. Neurol. 48 2000 194 200
48. J.R. Simon, S. Atweh, and M.J. Kuhar Sodium-dependent high affinity choline uptake: a regulatory step in the synthesis of acetylcholine J. Neurochem. 26 1976 909 922
49. H. Soreq, and S. Seidman Acetylcholinesterase-new roles for an old actor Nat. Rev. Neurosci. 2 2001 294 302
50. R. Van Der Putt, C. Dineen, D. Janes, H. Series, and R. McShane Effectiveness of acetylcholinesterase inhibitors: diagnosis and severity as predictors of response in routine practice Int. J. Geriatr. Psychiatry 21 2006 755 760
51. L.A. Volpicelli-Daley, A. Hrabovska, E.G. Duysen, S.M. Ferguson, R.D. Blakely, O. Lockridge, and A.I. Levey Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice Mol. Pharmacol. 64 2003 1309 1316
52. G.K. Wilcock Treatment for Alzheimer's disease Int. J. Geriatr. Psychiatry 15 2000 562 565
53. W. Xie, P.J. Wilder, J. Stribley, A. Chatonnet, A. Rizzino, P. Taylor, S.H. Hinrichs, and O. Lockridge Knockout of one acetylcholinesterase allele in the mouse Chem. Biol. Interact. 119-120 1999 289 299
54. Q. Yu, H.W. Holloway, T. Utsuki, A. Brossi, and N.H. Greig Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease J. Med. Chem. 42 1999 1855 1861
55. H.Y. Zhang, H. Yan, and X.C. Tang Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase Cell. Mol. Neurobiol. 28 2008 173 183
56. J. Zhou, Y. Fu, and X.C. Tang Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation Neurosci. Lett. 306 2001 53 56
57. M. Zimmermann Dementia in life writing: our health care system in the words of the sufferer Neurol. Sci. 32 2010 1233 1238
58. M. Zimmermann, B. Borroni, F. Cattabeni, A. Padovani, and M. Di Luca Cholinesterase inhibitors influence APP metabolism in Alzheimer disease patients Neurobiol. Dis. 19 2005 237 242
59. M. Zimmermann, S. Grosgen, M.S. Westwell, and S.A. Greenfield Selective enhancement of the activity of C-terminally truncated, but not intact, acetylcholinesterase J. Neurochem. 104 2008 221 232
60. M. Zimmermann, M.S. Westwell, and S.A. Greenfield Impact of detergents on the activity of acetylcholinesterase and on the effectiveness of its inhibitors Biol. Chem. 390 2009 19 26