Engineering islets for improved performance by optimized reaggregation in a micromold

Tissue Engineering - Part A

Volumn 19, Issue 5-6, 2013, Pages 604-612

  Ramachandran, Karthik ^a,b   Williams, S Janette ^b   Huang, Han Hung ^b   Novikova, Lesya ^b   Stehno Bittel, Lisa ^b  

^a University of Kansas   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; DIFFUSION BARRIERS; GLUCOSE; INSULIN; OPTIMIZATION; TISSUE;

BLOOD GLUCOSE; CELLULAR COMPOSITION; DIABETIC RATS; DRUG DISCOVERY; EMPIRICAL MODELING; FUNCTIONAL PROPERTIES; GLUCOSE DIFFUSION; GLUCOSE LEVEL; INSULIN MOLECULES; LIVE CELL; MICRO MOLDS; MICROVILLI; OXYGEN LEVELS; RE-AGGREGATION; SINGLE CELLS; SURVIVAL RATE; TISSUE PRODUCTION;

TISSUE ENGINEERING;

RATTUS;

PROINSULIN; TISSUE SCAFFOLD; GLUCOSE BLOOD LEVEL;

ANIMAL; ARTICLE; CELL AGGREGATION; CHEMISTRY; CYTOLOGY; DIFFUSION; GLUCOSE BLOOD LEVEL; METABOLISM; ORGAN SIZE; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; RAT; TISSUE ENGINEERING; TISSUE SURVIVAL; ULTRASTRUCTURE; TISSUE SCAFFOLD;

ANIMALS; BLOOD GLUCOSE; CELL AGGREGATION; DIFFUSION; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; ORGAN SIZE; PROINSULIN; RATS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TISSUE SURVIVAL;

EID: 84873385386     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2012.0553     Document Type: Article

References (37)

1. Centers for Disease Control and Prevention. National dia-betes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, 2011
2. Bretzel, R.G., Jahr, H., Eckhard, M., Martin, I., Winter, D., and Brendel, M.D. Islet cell transplantation today. Langen-becks Arch 392, 239, 2007
3. Digon, B.J. History of islet transplantation. Curr Diab Rep 9, 312, 2009
4. Ichii, H., and Ricordi, C. Current status of islet cell trans-plantation. J Hepatobiliary Pancreat Surg 16, 101, 2009
5. Korsgren, O., and Nilsson, B. Improving islet transplanta-tion: a road map for a widespread application for the cure of persons with type I diabetes. Curr Opin Organ Transplant 14, 683, 2009
6. Vaithilingam, V., Sundaram, G., and Tuch, B. Islet cell transplantation. Curr Opin Organ Transplant 13, 633, 2008
7. Shapiro, A., Lakey, J., Ryan, E., Korbutt, G., Toth, E., Warnock, G., Kneteman, N., and Rajotte, R. Islet transplan-tation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343, 230, 2000
8. Landsberg, D.N., and Shapiro, J. Kidney, pancreas, and pancreatic islet transplantation. BC Med J 52, 189, 2010
9. Vardanyan, M., Parkin, E., Gruessner, C., and Rodriguez Rilo, H.L. Pancreas vs. islet transplantation: a call on the future. Curr Opin Organ Transplant 15, 124, 2010
10. Lehmann, R., Zuellig, R., Kugelmeier, P., Baenninger, P., Moritz, W., Perren, A., Clavien, P., Weber, M., and Spinas, G. Superiority of small islets in human islet transplantation. Diabetes 56, 594, 2007
11. MacGregor, R.R., Williams, S.J., Tong, P.Y., Kover, K., Moore, W.V., and Stehno-Bittel, L. Small rat islets are su-perior to large islets in in vitro function and in transplanta-tion outcomes. Am J Physiol Endocrinol Metab 290, E771, 2006
12. Su, Z., Xia, J., Shao, W., Cui, Y., Tai, S., Ekberg, H., Corbascio, M., Chen, J., and Qi, Z. Small islets are essential for successful intraportal transplantation in a diabetes mouse model. Scand J Immunol 72, 504, 2010
13. Williams, S.J., Huang, H.-H., Kover, K., Moore, W.V., Berkland, C., Singh, M., Smirnova, I.V., MacGregor, R.R., and Stehno-Bittel, L. Reduction of diffusion barriers in iso-lated rat islets improves survival, but not insulin secretion or transplantation outcome. Organogenesis 6, 115, 2010
14. Brissova, M., Shostak, A., Shiota, M., Wiebe, P.O., Poffen-berger, G., Kantz, J., Chen, Z., Carr, C., Jerome, W.G., Chen, J., Baldwin, H.S., Nicholson, W., Bader, D.M., Jetton, T., Gannon, M., and Powers, A.C. Pancreatic islet production of vascular endothelial growth factor-a is essential for islet vascularization, revascularization, and function. Diabetes 55, 2974, 2006
15. Jansson, L., and Carlsson, P.-O. Graft vascular function after transplantation of pancreatic islets. Diabetologia 45, 749, 2002
16. Menger, M.D., Vajkoczy, P., Beger, C., and Messmer, K. Orientation of microvascular blood flow in pancreatic islet isografts. J Clin Invest 93, 2280, 1994
17. Nam, K.-H., Yong, W., Harvat, T., Adewola, A., Wang, S., Oberholzer, J., and Eddington, D.T. Size-based separation and collection of mouse pancreatic islets for functional analysis. Biomed Microdevices 12, 865, 2010
18. Halban, P.A., Wollheim, C.B., Blondel, B., Meda, P., Niesor, E.N., and Mintz, D.H. The possible importance of contact between pancreatic islet cells for the control of insulin release. Endocrinology 111, 86, 1982
19. Hopcroft, D.W., Mason, D.R., and Scott, R.S. Structure-function relationships in pancreatic islets: support for intraislet modulation of insulin secretion. Endocrinology 117, 2073, 1985
20. Lefèbvre, P. Diabetes as a paracrinopathy of the islets of langerhans. Eur J Endocrinol 2, 79, 2011
21. Marks, V., Tan, K.S., Stagner, J.I., and Samols, E. Intra-islet cellular interrelationships. Biochem Soc Trans 18, 103, 1990
22. Samols, E., Bonner-Weir, S., and Weir, G.C. Intra-islet insulin-glucagon-somatostatin relationships. Clin Endocrinol Metab 15, 33, 1986
23. Unger, R.H., and Orci, L. Paracrinology of islets and the paracrinopathy of diabetes. Proc Natl Acad Sci U S A 107, 16009, 2010
24. Weir, G.C., Halban, PA., Meda, P., Wollheim, C.B., Orci, L., and Renold, A.E. Dispersed adult rat pancreatic islet cells in culture: a, b, and d cell function. Metabolism 33, 447, 1984
25. Bavamian, S., Klee, P., Britan, A., Populaire, C., Caille, D., Cancela, J., Charollais, A., and Meda, P. Islet-cell-to-cell communication as basis for normal insulin secretion. Dia-betes Obes Metab 9, 118, 2007
26. Kelly, C., Guo, H., McCluskey, J., Flatt, P., and McClena-ghan, N. Comparison of insulin release from min6 pseu-doislets and pancreatic islets of langerhans reveals importance of homotypic cell interactions. Pancreas 39,1016, 2010
27. Kelly, C., Parke, H.G., McCluskey, J.T., Flatt, P.R., and McClenaghan, N.H. The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets. Diabetes Metab Res Rev 3, 41, 2010
28. Weber, L.M., Hayda, K.N., and Anseth, K.S. Cell-matrix interactions improve beta-cell survival and insulin secretion in three-dimensional culture. Tissue Eng Part A 14, 1959, 2008
29. Halban, P., Powers, S., George, K., and Bonner-Weir, S. Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architec-ture typical of native islets. Diabetes 36, 783, 1987
30. Hopcroft, D.W., Mason, D.R., and Scott, R.S. Insulin secre-tion from perifused rat pancreatic pseudoislets. In Vitro Cell Dev Biol 21, 421, 1985
31. Kodama, S., Kojima, K., Furuta, S., Chambers, M., Paz, A., and Vacanti, C. Engineering functional islets from cultured cells. Tissue Eng Part A 15, 3321, 2009
32. Lee, D., Park, S., Nam, J., and Byun, Y. Optimal aggregation of dissociated islet cells for functional islet-like cluster. J Biomater Sci Polym Ed 19, 441, 2008
33. Matta, S.G., Wobken, J.D., Williams, F.G., and Bauer, G.E. Pancreatic islet cell reaggregation systems: efficiency of cell reassociation and endocrine cell topography of rat islet-like aggregates. Pancreas 9, 439, 1994
34. O'Sullivan, E., Johnson, A., Omer, A., Hollister-Lock, J., Bonner-Weir, S., Colton, C., and Weir, G. Rat islet cell ag-gregates are superior to islets for transplantation in micro-capsules. Diabetologia 53, 937, 2010
35. Cavallari, G., Zuellig, R., Lehmann, R., Weber, M., and Moritz, W. Rat pancreatic islet size standardization by the ''hanging drop'' technique. Transplant Proc 39, 2018, 2007
36. Williams, S.J., Wang, Q., MacGregor, R.R., Siahaan, T., Stehno-Bittel, L., and Berkland, C. Adhesion of pancre-atic beta cells to biopolymer films. Biopolymers 91, 676, 2009
37. Huang, H.-H., Ramachandran, K., and Stehno-Bittel, L. A replacement for islet equivalents with improved reli-ability and validity. Acta Diabetol 2012 [Epub ahead of print]; DOI: 10.1007/s00592-012-0375-4