A replacement for islet equivalents with improved reliability and validity

Acta Diabetologica

Volumn 50, Issue 5, 2013, Pages 687-696

  Huang, Han Hung ^a   Ramachandran, Karthik ^b   Stehno Bittel, Lisa ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b University of Kansas   (United States)

Author keywords

Glut2; Islet equivalent; Islet volume; Proinsulin; Transplantation

Indexed keywords

DNA; GLUCOSE TRANSPORTER 2; PROINSULIN;

ANIMAL; CELL COUNT; CELL SIZE; CHEMISTRY; CYTOLOGY; FEMALE; HUMAN; MALE; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT;

ANIMALS; CELL COUNT; CELL SIZE; DNA; FEMALE; GLUCOSE TRANSPORTER TYPE 2; HUMANS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; PROINSULIN; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84885430106     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-012-0375-4     Document Type: Article

References (46)

1. MacGregor RR, Williams SJ, Tong PY, et al. (2006) Small rat islets are superior to large islets in in vitro function and in transplantation outcomes. Am J Physiol Endocrinol Metab 290(5):E771-E779
2. Buchwald P, Wang X, Khan A, et al. (2009) Quantitative assessment of islet cell products: estimating the accuracy of the existing protocol and accounting for islet size distribution. Cell Transpl 18(10):1223-1235
3. Ricordi C, Socci C, Davalli AM, et al. (1990) Isolation of the elusive pig islet. Surgery 107(6):688-694
4. Ricordi C, Gray DW, Hering BJ, et al. (1990) Islet isolation assessment in man and large animals. Acta Diabetol Lat 27(3):185-195
5. Ricordi C (1991) Quantitative and qualitative standards for islet isolation assessment in humans and large mammals. Pancreas 6(2):242-244
6. Ris F, Niclauss N, Morel P, et al. (2011) Islet autotransplantation after extended pancreatectomy for focal benign disease of the pancreas. Transplantation 91(8):895-901
7. Lehmann R, Zuellig RA, Kugelmeier P, et al. (2007) Superiority of small islets in human islet transplantation. Diabetes 56(3):594-603
8. Shapiro A, Lakey J, Ryan E, et al. (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343(4):230-238
9. Niclauss N, Bosco D, Morel P, et al. (2011) Influence of donor age on islet isolation and transplantation outcome. Transplantation 91(3):360-366
10. Bellin MD, Sutherland DE, Beilman GJ, et al. (2011) Similar islet function in islet allotransplant and autotransplant recipients, despite lower islet mass in autotransplants. Transplantation 91(3):367-372
11. Kessler L, Greget M, Metivier AC, et al. (2010) Combined pancreatic islets-lung transplantation in cystic fibrosis-related diabetes: case reports. Transpl Proc 42(10):4338-4340
12. Takita M, Naziruddin B, Matsumoto S, et al. (2011) Implication of pancreatic image findings in total pancreatectomy with islet autotransplantation for chronic pancreatitis. Pancreas 40(1):103-108
13. Sutton JM, Schmulewitz N, Sussman JJ, et al. (2010) Total pancreatectomy and islet cell autotransplantation as a means of treating patients with genetically linked pancreatitis. Surgery 148(4):676-685; discussion 685-676
14. Saito T, Gotoh M, Satomi S, et al. (2010) Islet transplantation using donors after cardiac death: report of the Japan islet transplantation registry. Transplantation 90(7):740-747
15. D'Aleo V, Del Guerra S, Gualtierotti G, et al. (2010) Functional and survival analysis of isolated human islets. Transpl Proc 42(6):2250-2251
16. Matsumoto S, Noguchi H, Takita M, et al. (2010) Super-high-dose islet transplantation is associated with high SUITO index and prolonged insulin independence: a case report. Transpl Proc 42(6):2156-2158
17. Shimoda M, Noguchi H, Naziruddin B, et al. (2010) Assessment of human islet isolation with four different collagenases. Transpl Proc 42(6):2049-2051
18. Shimoda M, Noguchi H, Naziruddin B, et al. (2010) Improved method of human islet isolation for young donors. Transpl Proc 42(6):2024-2026
19. Kessler L, Bakopoulou S, Kessler R, et al. (2010) Combined pancreatic islet-lung transplantation: a novel approach to the treatment of end-stage cystic fibrosis. Am J Transpl 10(7):1707-1712
20. O'Gorman D, Kin T, Imes S, et al. (2010) Comparison of human islet isolation outcomes using a new mammalian tissue-free enzyme versus collagenase NB-1. Transplantation 90(3):255-259
21. Balamurugan AN, Breite AG, Anazawa T, et al. (2010) Successful human islet isolation and transplantation indicating the importance of class 1 collagenase and collagen degradation activity assay. Transplantation 89(8):954-961
22. Kaddis JS, Danobeitia JS, Niland JC, Stiller T, Fernandez LA (2010) Multicenter analysis of novel and established variables associated with successful human islet isolation outcomes. Am J Transpl 10(3):646-656
23. Fujita Y, Takita M, Shimoda M, et al. (2011) Large human islets secrete less insulin per islet equivalent than smaller islets in vitro. Islets 3(1):1-5
24. Huang HH, Novikova L, Williams SJ, Smirnova IV, Stehno-Bittel L (2011) Low insulin content of large islet population is present in situ and in isolated islets. Islets 3(1):6-13
25. Williams S, Huang H-H, Kover K, et al. (2010) Reduction of diffusion barriers in isolated islets improves survival. But not insulin secretion. Organogenesis 6(2):115-124
26. Kissler HJ, Niland JC, Olack B, et al. (2010) Validation of methodologies for quantifying isolated human islets: an Islet Cell Resources Study. Clin Transpl 24(2):236-242
27. Niclauss N, Sgroi A, Morel P, et al. (2008) Computer-assisted digital image analysis to quantify the mass and purity of isolated human islets before transplantation. Transplantation 86(11):1603-1609
28. Fetterhoff TJ, Wile KJ, Coffing D, Cavanagh T, Wright MJ (1994) Quantitation of isolated pancreatic islets using imaging technology. Transpl Proc 26(6):3351
29. van der Burg MP, Scheringa M, Basir I, Bouwman E (1997) Assessment of isolated islet equivalents. Transpl Proc 29(4):1971-1973
30. Pisania A, Papas KK, Powers DE, et al. (2010) Enumeration of islets by nuclei counting and light microscopic analysis. Lab Invest 90(11):1676-1686
31. Pisania A, Weir GC, O'Neil JJ, et al. (2010) Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest 90(11):1661-1675
32. Perez-Armendariz E, Atwater I, Rojas E (1985) Glucose-induced oscillatory changes in extracellular ionized potassium concentration in mouse islets of Langerhans. Biophys J 48(5):741-749
33. Lehmann R, Fernandez LA, Bottino R, et al. (1998) Evaluation of islet isolation by a new automated method (Coulter Multisizer Ile) and manual counting. Transpl Proc 30(2):373-374
34. Cummings BP, Digitale EK, Stanhope KL, et al. (2008) Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat. Am J Physiol Regul Integr Comp Physiol 295(6):R1782-R1793
35. Girman P, Berkova Z, Dobolilova E, Saudek F (2008) How to use image analysis for islet counting. Rev Diabet Stud 5(1):38-46
36. Avgoustiniatos E (2002) Oxygen diffusion limitations in pancreatic islet culture and immunoisolation. Massachusetts Institute of Technology, Cambridge
37. Stegemann JP, O'Neil JJ, Nicholson DT, Mullon CJ, Solomon BA (1997) Automated counting and sizing of isolated porcine islets using digital image analysis. Transpl Proc 29(4):2272-2273
38. Stegemann JP, O'Neil JJ, Nicholson DT, Mullon CJ (1998) Improved assessment of isolated islet tissue volume using digital image analysis. Cell Transpl 7(5):469-478
39. Girman P, Kriz J, Friedmansky J, Saudek F (2003) Digital imaging as a possible approach in evaluation of islet yield. Cell Transpl 12(2):129-133
40. Lembert N, Wesche J, Petersen P, et al. (2003) Areal density measurement is a convenient method for the determination of porcine islet equivalents without counting and sizing individual islets. Cell Transpl 12(1):33-41
41. Friberg AS, Brandhorst H, Buchwald P, et al. (2011) Quantification of the islet product: presentation of a standardized current good manufacturing practices compliant system with minimal variability. Transplantation 91(6):677-683
42. Williams S, Wang Q, MacGregor R, et al. (2009) Adhesion of pancreatic beta cells to biopolymer films. Biopolymers 91(8):676-685
43. Pipeleers DG, in't Veld PA, Van de Winkel M, et al. (1985) A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117(3):806-816
44. Lernmark A (1974) The preparation of, and studies on, free cell suspensions from mouse pancreatic islets. Diabetologia 10(5):431-438
45. Korsgren O, Nilsson B, Berne C, et al. (2005) Current status of clinical islet transplantation. Transplantation 79(10):1289-1293
46. Hellman B (1959) Actual distribution of the number and volume of the islets of Langerhans in different size classes in non-diabetic humans of varying ages. Nature 184(Suppl 19):1498-1499