Following healthy pregnancy by nuclear magnetic resonance (NMR) metabolic profiling of human urine

Journal of Proteome Research

Volumn 12, Issue 2, 2013, Pages 969-979

  Diaz, Sílvia O ^a   Barros, António S ^a   Goodfellow, Brian J ^a   Duarte, Iola F ^a   Carreira, Isabel M ^b   Galhano, Eulália ^c   Pita, Cristina ^c   Almeida, Maria Do Céu ^c   Gil, Ana M ^a  

^a UNIVERSITY OF AVEIRO   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

Author keywords

metabolic trajectory; metabolomics; metabonomics; multivariate analysis; NMR; pregnancy; prenatal health; urine

Indexed keywords

3 HYDROXYBUTYRIC ACID; 4 DEOXYERYTHRONIC ACID; 4 DEOXYTHREONIC ACID; CHOLINE; CREATININE; FUROYLGLYCINE; GUANIDINOACETIC ACID; GUANIDOACETATE; ISOLEUCINE; KETONE BODY; LACTIC ACID; METHIONINE; TAURINE; THREONINE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID METABOLISM; AMINOACIDURIA; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; KETOGENESIS; LIPID OXIDATION; MAJOR CLINICAL STUDY; METABOLOMICS; MONTE CARLO METHOD; NUCLEAR MAGNETIC RESONANCE IMAGING; PREGNANCY; PRIORITY JOURNAL; SPECTROSCOPY; STATISTICAL TOTAL CORRELATION SPECTROSCOPY; UREA CYCLE; URINALYSIS;

ACIDS, ACYCLIC; ADULT; AMINO ACIDS; BIOLOGICAL MARKERS; CHOLINE; CREATININE; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOME; MONTE CARLO METHOD; MULTIVARIATE ANALYSIS; PREGNANCY; PREGNANCY TRIMESTERS; PRINCIPAL COMPONENT ANALYSIS;

EID: 84873370758     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr301022e     Document Type: Article

References (51)

1. nd ed.; Informa Healthcare: London, U.K., 2008.
2. th ed.; Elsevier Saunders: Philadelphia, U.S., 2004.
3. 1H-NMR-based metabolic profiling of maternal and umbilical cord blood indicates altered materno-foetal nutrient exchange in preterm infants PLoS One 2012, 7, e29947
4. Graça, G.; Goodfellow, B. J.; Barros, A. S.; Diaz, S.; Duarte, I. F.; Spagou, K.; Veselkov, K.; Want, E. J.; Lindon, J. C.; Carreira, I. M.; Galhano, E.; Pita, C.; Gil, A. M. UPLC-MS metabolic profiling of second trimester amniotic fluid and maternal urine and comparison with NMR spectral profiling for the identification of pregnancy disorder biomarkers Mol. BioSys. 2012, 8, 1243-1254
5. Diaz, S. O.; Pinto, J.; Graça, G.; Duarte, I. F.; Barros, A. S.; Galhano, E.; Pita, C.; Almeida, M. C.; Goodfellow, B. J.; Carreira, I. M.; Gil, A. M. Metabolic biomarkers of prenatal disorders: An exploratory NMR metabonomics study of 2nd trimester maternal urine and blood plasma J. Proteome Res. 2011, 10, 3732-3742
6. Horgan, R. P.; Broadhurst, D. I.; Dunn, W. B.; Brown, M.; Heazell, A. E. P.; Kell, D. B.; Baker, P. N.; Kenny, L. C. Changes in the metabolic footprint of placental explant-conditioned medium cultured in different oxygen tensions from placentas of small for gestational age and normal pregnancies Placenta 2010, 31, 893-901
7. Kenny, L. C.; Broadhurst, D. I.; Dunn, W.; Brown, M.; North, R. A.; McCowan, L.; Roberts, C.; Cooper, G. J. S.; Kell, D. B.; Baker, P. N. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers Hypertension 2010, 56, 741-749
8. Dunn, W.; Brown, M.; Worton, S.; Davies, K.; Jones, R.; Kell, D.; Heazell, A. The metabolome of human placental tissue: Investigation of first trimester tissue and changes related to preeclampsia in late pregnancy Metabolomics 2012, 8, 579-597
9. Heazell, A. E. P.; Bernatavicius, G.; Warrander, L.; Brown, M. C.; Dunn, W. B.; Metabolomic, A. Approach identifies differences in maternal serum in third trimester pregnancies that end in poor perinatal outcome Reprod. Sci. 2012, 19, 863-875
10. Lindon, J. C.; Holmes, E.; Bollard, M. E.; Stanley, E. G.; Nicholson, J. K. Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis Biomarkers 2004, 9, 1-31
11. Madsen, R.; Lundstedt, T.; Trygg, J. Chemometrics in metabolomics-A review in human disease diagnosis Anal. Chim. Acta 2010, 659, 23-33
12. Turner, E.; Brewster, J. A.; Simpson, N. A. B.; Walker, J. J.; Fisher, J. Plasma from women with preeclampsia has a low lipid and ketone body content-A nuclear magnetic resonance study Hypertens. Pregnancy 2007, 26, 329-342
13. Turner, E.; Brewster, J. A.; Simpson, N. A. B.; Walker, J. J.; Fisher, J. Aromatic amino acid biomarkers of preeclampsia-A nuclear magnetic resonance investigation Hypertens. Pregnancy 2008, 27, 225-235
14. Dunn, W. B.; Brown, M.; Worton, S. A.; Crocker, I. P.; Broadhurst, D.; Horgan, R.; Kenny, L. C.; Baker, P. N.; Kell, D. B.; Heazell, A. E. P. Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia Placenta 2009, 30, 974-980
15. Bock, J. L. Metabolic profiling of amniotic fluid by proton nuclear magnetic resonance spectroscopy: correlation with fetal maturation and other clinical variables Clin. Chem 1994, 40, 56-61
16. 1H NMR spectroscopy of amniotic fluids from spina bifida fetuses and controls Eur. J. Obstet. Gyn. R. B. 2004, 112, 16-23
17. 1H NMR based metabonomics of human amniotic fluid for the metabolic characterization of fetus malformations J. Proteome Res. 2009, 8, 4144-4150
18. Graça, G.; Duarte, I. F.; Barros, A. S.; Goodfellow, B. J.; Diaz, S. O.; Pinto, J.; Carreira, I. M.; Galhano, E.; Pita, C.; Gil, A. M. Impact of prenatal disorders on the metabolic profile of second trimester amniotic fluid: A nuclear magnetic resonance metabonomic study J. Proteome Res. 2010, 9, 6016-6024
19. Horgan, R. P.; Broadhurst, D. I.; Walsh, S. K.; Dunn, W. B.; Brown, M.; Roberts, C. T.; North, R. A.; McCowan, L. M.; Kell, D. B.; Baker, P. N.; Kenny, L. C. Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy J. Proteome Res. 2011, 10, 3660-3673
20. King, J. C. Physiology of pregnancy and nutrient metabolism Am. J. Clin. Nutr. 2000, 71, 1218S-1225S
21. Herrera, E. Lipid metabolism in pregnancy and its consequences in the fetus and newborn Endocrine 2002, 19, 43-55
22. Sims, C. J.; Fujito, D. T.; Burholt, D. R.; Dadok, J.; Wilkinson, D. A. Comparison of metabolite levels in second and third trimester human amniotic fluid samples using proton magnetic resonance spectroscopy J. Matern.-Fetal. Investig. 1996, 6, 62-66
23. Cohn, B. R.; Fukuchi, E. Y.; Joe, B. N.; Swanson, M. G.; Kurhanewicz, J.; Yu, J.; Caughey, A. B. Calculation of gestational age in late second and third trimesters by ex vivo magnetic resonance spectroscopy of amniotic fluid Am. J. Obstet. Gynecol. 2010, 203, 76.e1-76.e10
24. Ottolenghi, C.; Abermil, N.; Lescoat, A.; Aupetit, J.; Beaugendre, O.; Morichon-Delvallez, N.; Ricquier, D.; Chadefaux-Vekemans, B.; Rabier, D. Gestational age-related reference values for amniotic fluid organic acids Prenatal Diag. 2010, 30, 43-48
25. Athanasiadis, A. P.; Michaelidou, A.-M.; Fotiou, M.; Menexes, G.; Theodoridis, T. D.; Ganidou, M.; Tzevelekis, B.; Assimakopoulos, E.; Tarlatzis, B. C. Correlation of 2nd trimester amniotic fluid amino acid profile with gestational age and estimated fetal weight J. Matern.-Fetal Neonatal Med. 2011, 24, 1033-1038
26. Dasarathy, J.; Gruca, L. L.; Bennett, C.; Parimi, P. S.; Duenas, C.; Marczewski, S.; Fierro, J. L.; Kalhan, S. C. Methionine metabolism in human pregnancy Am. J. Clin. Nutr. 2010, 91, 357-365
27. Cho, S.-W.; Cha, Y.-S. Pregnancy increases urinary loss of carnitine and reduces plasma carnitine in Korean women Br. J. Nutr. 2005, 93, 685-691
28. Hytten, F. E. The renal excretion of nutrients in pregnancy Postgrad. Med. J. 1973, 49, 625-629
29. th ed.; Saunders Elsevier: Philadelphia, U.S., 2009.
30. Wishart, D. S.; Knox, C.; Guo, A. C.; Eisner, R.; Young, N.; Gautam, B.; Hau, D. D.; Psychogios, N.; Dong, E.; Bouatra, S.; Mandal, R.; Sinelnikov, I.; Xia, J.; Jia, L.; Cruz, J. A.; Lim, E.; Sobsey, C. A.; Shrivastava, S.; Huang, P.; Liu, P.; Fang, L.; Peng, J.; Fradette, R.; Cheng, D.; Tzur, D.; Clements, M.; Lewis, A.; De Souza, A.; Zuniga, A.; Dawe, M.; Xiong, Y.; Clive, D.; Greiner, R.; Nazyrova, A.; Shaykhutdinov, R.; Li, L.; Vogel, H. J.; Forsythe, I. HMDB: A knowledgebase for the human metabolome Nucleic Acids Res. 2009, 37 (suppl 1) D603-D610
31. 1H NMR spectra for improved metabolic biomarker recovery Anal. Chem. 2009, 81, 56-66
32. 1H NMR metabonomics Anal. Chem. 2006, 78, 4281-4290
33. Joliffe, I. T.; Morgan, B. J. Principal component analysis and exploratory factor analysis Stat. Methods Med. Res. 1992, 1, 69-95
34. Barker, M.; Rayens, W. Partial least squares for discrimination J. Chemometr. 2003, 17, 166-173
35. Wiklund, S.; Nilsson, D.; Eriksson, L.; Sjöström, M.; Wold, S.; Faber, K. A randomization test for PLS component selection J. Chemometr. 2007, 21, 427-439
36. Westerhuis, J.; Hoefsloot, H.; Smit, S.; Vis, D.; Smilde, A.; van Velzen, E.; van Duijnhoven, J.; van Dorsten, F. Assessment of PLSDA cross validation Metabolomics 2008, 4, 81-89
37. Nakagawa, S.; Cuthill, I. C. Effect size, confidence interval and statistical significance: A practical guide for biologists Biol. Rev. 2007, 82, 591-605
38. 1H NMR data sets Anal. Chem. 2005, 77, 1282-1289
39. Llorach, R.; Garcia-Aloy, M.; Tulipani, S.; Vazquez-Fresno, R.; Andres-Lacueva, C. Nutrimetabolomic strategies to develop new biomarkers of intake and health effects J. Agric. Food Chem. 2012, 60, 8797-8808
40. Miller, S.; Ruttinger, V.; Macy, I. G. Urinary excretion of ten amino acids by women during the reproductive cycle J. Biol. Chem. 1954, 209, 795-801
41. Appiah-Amponsah, E.; Shanaiah, N.; Nagana Gowda, G. A.; Owusu-Sarfo, K.; Ye, T.; Raftery, D. Identification of 4-deoxythreonic acid present in human urine using HPLC and NMR techniques J. Pharmaceut. Biomed. 2009, 50, 878-885
42. Ellis, J.; Athersuch, T.; Thomas, L.; Teichert, F.; Perez-Trujillo, M.; Svendsen, C.; Spurgeon, D.; Singh, R.; Jarup, L.; Bundy, J.; Keun, H. C. Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population BMC Med. 2012, 10, 61-71
43. Brosnan, J. T.; Brosnan, M. E. Creatine metabolism and the urea cycle Mol. Genet. Metab. 2010, 100 (Suppl 1) S49-S52
44. Kumps, A.; Duez, P.; Mardens, Y. Metabolic, nutritional, iatrogenic, and artifactual sources of urinary organic acids: A comprehensive table Clin. Chem. 2002, 48, 708-717
45. Ombrone, D.; Salvatore, F.; Ruoppolo, M. Quantitative liquid chromatography coupled with tandem mass spectrometry analysis of urinary acylglycines: Application to the diagnosis of inborn errors of metabolism Anal. Biochem. 2011, 417, 122-128
46. Gallery, E. D. M.; Ross, M.; Gyory, A. Z. 24-h urinary creatinine excretion is not altered in human pregnancy Hypertens. Pregnancy 1996, 15, 257-261
47. 1H NMR-based metabonomic techniques in nutrition research metabolic effects of dietary isoflavones in humans J. Nutr. Biochem. 2005, 16, 236-244
48. Stella, C.; Beckwith-Hall, B.; Cloarec, O.; Holmes, E.; Lindon, J. C.; Powell, J.; van der Ouderaa, F.; Bingham, S.; Cross, A. J.; Nicholson, J. K. Susceptibility of human metabolic phenotypes to dietary modulation J. Proteome Res. 2006, 5, 2780-2788
49. 1H NMR and MRS data from different biofluids and tissues enhances recovery of biological information from individuals with HIV-1 infection J. Proteome Res. 2011, 10, 1737-1745
50. Rivière, C.; Thi Hong, V. N.; Hoai, N. N.; Dejaegher, B.; Tistaert, C.; Van, K. P.; Heyden, Y. V.; Van, C.; Quetin-Leclercq, M. J. N -methyl-5-carboxamide-2-pyridone from Mallotus barbatus: A chemosystematic marker of the Euphorbiaceae genus Mallotus Biochem. Syst. Ecol. 2012, 44, 212-215
51. Rezzi, S.; Ramadan, Z.; Martin, F. P. J.; Fay, L. B.; van Bladeren, P.; Lindon, J. C.; Nicholson, J. K.; Kochhar, S. Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals J. Proteome Res. 2007, 6, 4469-4477