Exhaustive training increases uncoupling protein 2 expression and decreases Bcl-2/bax ratio in rat skeletal muscle

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2013, Pages

  Liu, W Y ^a   He, W ^b   Li, H ^c  

^a SHANGHAI UNIVERSITY OF SPORT   (China)

^b Shanghai Jing'an Geriatric Hospital   (China)

^c NEIJIANG NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIAPOPTOTIC; CONTROL GROUPS; FEMALE RAT; GASTROCNEMIUS MUSCLE; MALONDIALDEHYDE; MITOCHONDRIAL ENERGY; RAT SKELETAL MUSCLE; SUPEROXIDE DISMUTASES; UNCOUPLING PROTEINS; XANTHINE OXIDASE;

ALDEHYDES; OXYGEN;

PROTEINS;

ADENOSINE TRIPHOSPHATASE; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCOUPLING PROTEIN 2; XANTHINE OXIDASE; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENERGY YIELD; EXHAUSTION; FEMALE; GASTROCNEMIUS MUSCLE; MITOCHONDRION; NONHUMAN; OVEREXERTION; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SKELETAL MUSCLE; ANIMAL; BODY WEIGHT; METABOLISM; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BODY WEIGHT; FEMALE; ION CHANNELS; MALONDIALDEHYDE; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; OXIDATIVE STRESS; PHYSICAL CONDITIONING, ANIMAL; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

EID: 84873329976     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2013/780719     Document Type: Article

References (45)

1. Snyder A. C., Overtraining and glycogen depletion hypothesis. Medicine and Science in Sports and Exercise 1998 30 7 1146 1150 2-s2.0-0031846523 10.1097/00005768-199807000-00020 (Pubitemid 28317714)
2. Liu W. Y., Lu A. Y., Effect of overtraining on skeletal muscle glycogen, AMPK activity and sarcolemma GLUT4 protein content in rats. Chinese Journal of Sports Medicine 2006 25 6 668 673
3. Liu T. M., Zhang Y. L., Experimental study on the glutamine's intervention effect on the opening of permeability transition pore in myocardial mitochondrial membrane. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2012 28 1 34 37
4. Halestrap A. P., What is the mitochondrial permeability transition pore? Journal of Molecular and Cellular Cardiology 2009 46 6 821 831 2-s2.0-67349117275 10.1016/j.yjmcc.2009.02.021
5. Szabadkai G., Rizzuto R., Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood? FEBS Letters 2004 567 1 111 115 2-s2.0-2542448093 10.1016/j.febslet.2004.04.059 (Pubitemid 38686432)
6. Yi X., Yin X. M., Dong Z., Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed. Journal of Biological Chemistry 2003 278 19 16992 16999 2-s2.0-0038268159 10.1074/jbc.M300039200 (Pubitemid 36799574)
7. Ding S. Z., Wang W. X., Lian K. J., Xu H. W., The effect of exhaustive swimming on calcium transport in rat heart mitochondria. Shengwu Hua Xue Za Zhi 1995 11 3 366 367
8. Kim H. R., Lee G. H., Cho E. Y., Chae S. W., Ahn T., Chae H. J., Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1. Journal of Cell Science 2009 122 8 1126 1133 2-s2.0-66849138212 10.1242/jcs.038430
9. Echtay K. S., Roussel D., St-Plerre J., Jekabsons M. B., Cadenas S., Stuart J. A., Harper J. A., Roebuck S. J., Morrison A., Pickering S., Clapham J. C., Brand M. D., Superoxide activates mitochondrial uncoupling proteins. Nature 2002 415 6867 96 99 2-s2.0-18244379331 10.1038/415096a (Pubitemid 34062457)
10. Derdak Z., Garcia T. A., Baffy G., Detection of uncoupling protein-2 (UCP2) as a mitochondrial modulator of apoptosis. Methods in Molecular Biology 2009 559 205 217 2-s2.0-70349778265 10.1007/978-1-60327-017-5-15
11. Bedford T. G., Tipton C. M., Wilson N. C., Maximum oxygen consumption of rats and its changes with various experimental procedures. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology 1979 47 6 1278 1283 2-s2.0-0018579341 (Pubitemid 10168974)
12. Alonso M., Collado P. S., González-Gallego J., Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle. Journal of Pineal Research 2006 41 1 8 14 2-s2.0-33745574971 10.1111/j.1600-079X.2006.00323.x (Pubitemid 43980689)
13. Sherratt H. S., Watmough N. J., Johnson M. A., Turnbull D. M., Methods for study of normal and abnormal skeletal muscle mitochondria. Methods of Biochemical Analysis 1988 33 243 335 2-s2.0-0023672229
14. Cunningham O., McElligott A. M., Carroll A. M., Breen E., Reguenga C., Oliveira M. E. M., Azevedo J. E., Porter R. K., Selective detection of UCP 3 expression in skeletal muscle: effect of thyroid status and temperature acclimation. Biochimica et Biophysica Acta 2003 1604 3 170 179 2-s2.0-0038094406 10.1016/S0005-2728(03)00057-4 (Pubitemid 36776750)
15. Lehmann M. J., Lormes W., Opitz-Gress A., Steinacker J. M., Netzer N., Foster C., Gastmann U., Training and overtraining: an overview and experimental results in endurance sports. Journal of Sports Medicine and Physical Fitness 1997 37 1 7 17 2-s2.0-0030953248 (Pubitemid 27242705)
16. Hohl R., Ferraresso R. L. P., De Oliveira R. B., Lucco R., Brenzikofer R., De Macedo D. V., Development and characterization of an overtraining animal model. Medicine and Science in Sports and Exercise 2009 41 5 1155 1163 2-s2.0-67650088835 10.1249/MSS.0b013e318191259c
17. Sun X. L., Liu Y., Dai T., Ding J. H., Hu G., Uncoupling protein 2 knockout exacerbates depression-like behaviors in mice via enhancing inflammatory response. Neuroscience 2011 192 507 514
18. Niess A. M., Dickhuth H. H., Northoff H., Fehrenbach E., Free radicals and oxidative stress in exercise-immunological aspects. Exercise Immunology Review 1999 5 22 56 2-s2.0-0032780246 (Pubitemid 29340640)
19. Gómez-Cabrera M. C., Pallardó F. V., Sastre J., Viña J., Garcia-Del-Moral L., Allopurinol and markers of muscle damage among participants in the tour de France. Journal of the American Medical Association 2003 289 19 2503 2504 2-s2.0-0037636772 10.1001/jama.289.19.2503-b (Pubitemid 37430151)
20. Zoppi C. C., MacEdo D. V., Overreaching-induced oxidative stress, enhanced HSP72 expression, antioxidant and oxidative enzymes downregulation. Scandinavian Journal of Medicine and Science in Sports 2008 18 1 67 76 2-s2.0-39449119151 10.1111/j.1600-0838.2006.00630.x
21. Knez W. L., Jenkins D. G., Coombes J. S., Oxidative stress in half and full Ironman triathletes. Medicine and Science in Sports and Exercise 2007 39 2 283 288 2-s2.0-33846837462 10.1249/01.mss.0000246999.09718.0c (Pubitemid 46204295)
22. Tanskanen M., Atalay M., Uusitalo A., Altered oxidative stress in overtrained athletes. Journal of Sports Sciences 2010 28 3 309 317 2-s2.0-77949391048 10.1080/02640410903473844
23. Margonis K., Fatouros I. G., Jamurtas A. Z., Nikolaidis M. G., Douroudos I., Chatzinikolaou A., Mitrakou A., Mastorakos G., Papassotiriou I., Taxildaris K., Kouretas D., Oxidative stress biomarkers responses to physical overtraining: implications for diagnosis. Free Radical Biology and Medicine 2007 43 6 901 910 2-s2.0-34547806238 10.1016/j.freeradbiomed.2007.05.022 (Pubitemid 47241203)
24. Echigoya Y., Morita S., Itou T., Sakai T., Effects of extracellular lactate on production of reactive oxygen species by equine polymorphonuclear leukocytes in vitro. American Journal of Veterinary Research 2012 73 8 1290 1298
25. Nie J., Jiang C., Zhang Y., Shi Q., Liu S., Study on molecular mechanism of exercise-induced fatigue in mitochondrial membrane. IV. Relationships between proton potential energy across membrane, proton leak and ROS generation during acute exercise. Chinese Journal of Sports Medicine 2001 20 2 134 138
26. Lambert A. J., Brand M. D., Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane. Biochemical Journal 2004 382 2 511 517 2-s2.0-4043090717 10.1042/BJ20040485 (Pubitemid 39243917)
27. Mailloux R. J., Harper M. E., Uncoupling proteins and the control of mitochondrial reactive oxygen species production. Free Radical Biology and Medicine 2011 51 6 1106 1115
28. Brand M. D., Affourtit C., Esteves T. C., Green K., Lambert A. J., Miwa S., Pakay J. L., Parker N., Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radical Biology and Medicine 2004 37 6 755 767 2-s2.0-4043147798 10.1016/j.freeradbiomed.2004.05.034 (Pubitemid 39078548)
29. Cortright R. N., Zheng D., Jones J. P., Fluckey J. D., DiCarlo S. E., Grujic D., Lowell B. B., Dohm G. L., Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation. American Journal of Physiology 1999 276 1 E217 E221 2-s2.0-0032932936 (Pubitemid 29065613)
30. Degasperi G. R., Romanatto T., Denis R. G. P., Araújo E. P., Moraes J. C., Inada N. M., Vercesi A. E., Velloso L. A., UCP2 protects hypothalamic cells from TNF- α -induced damage. FEBS Letters 2008 582 20 3103 3110 2-s2.0-49849089333 10.1016/j.febslet.2008.08.006
31. Chan C. B., De Leo D., Joseph J. W., McQuaid T. S., Ha X. F., Xu F., Tsushima R. G., Pennefather P. S., Salapatek A. M. F., Wheeler M. B., Increased uncoupling protein-2 levels in β -cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 2001 50 6 1302 1310 2-s2.0-0034990987 (Pubitemid 32500162)
32. Stuart J. A., Harper J. A., Brindle K. M., Jekabsons M. B., Brand M. D., Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. Journal of Biological Chemistry 2001 276 21 18633 18639 2-s2.0-0035947694 10.1074/jbc.M011566200
33. Chavin K. D., Yang S., Lin H. Z., Chatham J., Chacko V. P., Hock J. B., Walajtys-Rode E., Rashid A., Chen C. H., Huang C. C., Wu T. C., Lane M. D., Diehl A. M., Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. Journal of Biological Chemistry 1999 274 9 5692 5700 2-s2.0-0033605261 10.1074/jbc.274.9.5692 (Pubitemid 29109222)
34. Bouillaud F., UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing. Biochimica et Biophysica Acta 2009 1787 5 377 383 2-s2.0-65549105815 10.1016/j.bbabio.2009. 01.003
35. Westerblad H., Allen D. G., Emerging roles of ROS/RNS in muscle function and fatigue, Antioxidants. Redox Signaling 2011 15 9 2487 2499
36. Bellinger A. M., Reiken S., Dura M., Murphy P. W., Deng S. X., Landry D. W., Nieman D., Lehnart S. E., Samaru M., LaCampagne A., Marks A. R., Remodeling of ryanodine receptor complex causes"leaky" channels: a molecular mechanism for decreased exercise capacity. Proceedings of the National Academy of Sciences of the United States of America 2008 105 6 2198 2202 2-s2.0-41149180560 10.1073/pnas.0711074105 (Pubitemid 351439488)
37. Li N., Wang J., Gao F., Tian Y., Song R., Zhu S. J., The role of uncoupling protein 2 in the apoptosis induced by free fatty acid in rat cardiomyocytes. Journal of Cardiovascular Pharmacology 2010 55 2 161 167 2-s2.0-77649323982 10.1097/01.fjc.0000365898.92719.f0
38. Deng S., Yang Y., Han Y., Li X., Wang X., Zhang Z., Wang Y., UCP2 inhibits ROS-mediated apoptosis in A549 under hypoxic conditions. PLoS ONE 2012 7 1 e30714
39. Oltvai Z. N., Milliman C. L., Korsmeyer S. J., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death. Cell 1993 74 4 609 619 2-s2.0-0027166048 10.1016/0092-8674(93)90509-O (Pubitemid 23259742)
40. Kamata H., Honda S. I., Maeda S., Chang L., Hirata H., Karin M., Reactive oxygen species promote TNF α -induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005 120 5 649 661 2-s2.0-14844327760 10.1016/j.cell.2004.12.041 (Pubitemid 40343077)
41. Kluck R. M., Bossy-Wetzel E., Green D. R., Newmeyer D. D., The release of cytochrome c from mitochondria: a primary site for Bcl- 2 regulation of apoptosis. Science 1997 275 5303 1132 1136 2-s2.0-0031037897 10.1126/science.275.5303.1132 (Pubitemid 27097313)
42. Narita M., Shimizu S., Ito T., Chittenden T., Lutz R. J., Matsuda H., Tsujimoto Y., Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proceedings of the National Academy of Sciences of the United States of America 1998 95 25 14681 14686 2-s2.0-0032422488 10.1073/pnas.95.25.14681 (Pubitemid 29003690)
43. Cosulich S. C., Savory P. J., Clarke P. R., Bcl-2 regulates amplification of caspase activation by cytochrome c. Current Biology 1999 9 3 147 150 2-s2.0-0033545382 10.1016/S0960-9822(99)80068-2 (Pubitemid 29087544)
44. Villani G., Greco M., Papa S., Attardi G., Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types. Journal of Biological Chemistry 1999 273 48 31829 31836 2-s2.0-0033610865 10.1074/jbc.273.48.31829 (Pubitemid 29177118)
45. Kadenbach B., Arnold S., Lee I., Hüttemann M., The possible role of cytochrome c oxidase in stress-induced apoptosis and degenerative diseases. Biochimica et Biophysica Acta 2004 1655 1-3 400 408 2-s2.0-1942536167 10.1016/j.bbabio.2003.06.005 (Pubitemid 38526204)