The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 304, Issue 3, 2013, Pages

  Crump, Shawn M ^a   Andres, Douglas A ^a   Sievert, Gail ^a   Satin, Jonathan ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Calcium current; Calcium transients; Cardiac myocytes; Cardiomyocytes; L type calcium channel

Indexed keywords

CALCIUM; CALCIUM CHANNEL L TYPE;

ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; HEART MUSCLE CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; SARCOPLASMIC RETICULUM;

ANIMALS; BARIUM; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CARDIAC PACING, ARTIFICIAL; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; HEART; HEK293 CELLS; HUMANS; KINETICS; MICE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PREGNANCY;

EID: 84873314764     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00396.2012     Document Type: Article

References (39)

1. 2+ channels to a caveolar macromolecular signaling complex is required for beta-adrenergic regulation. Proc Natl Acad Sci USA 103: 7500-7505, 2006.
2. Bers DM. Cardiac excitation-contraction coupling. Nature 415: 198-205, 2002.
3. Bers DM. Excitation-contraction coupling and cardiac contractile force. Boston: Kluwer Academic Publishers, 2001.
4. Bers DM, Stiffel VM. Ratio of ryanodine to dihydropyridine receptors in cardiac and skeletal muscle and implications for EC coupling. Am J Physiol Cell Physiol 264: C1587-C1593, 1993.
5. Biel M, Ruth P, Bosse E, Hullin R, Stuhmer W, Flockerzi V, Hofmann F. Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung. FEBS Lett 269: 409-412, 1990.
6. 2+, the proximal C-terminal EF-hand, and the distal C-terminal domain. J Gen Physiol 134: 81-94, 2009.
7. Cohen NM, Lederer WJ. Changes in the calcium current of rat heart ventricular myocytes during development. J Physiol 406: 115-146, 1988.
8. Crump SM, Correll RN, Schroder EA, Lester WC, Finlin BS, Andres DA, Satin J. L-type calcium channel a-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. Am J Physiol Heart Circ Physiol 291: H1959-H1971, 2006.
9. Dai S, Hall DD, Hell JW. Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev 89: 411-452, 2009.
10. Doshi D, Marx SO. Ion channels, transporters, and pumps as targets for heart failure therapy. J Cardiovasc Pharmacol 54: 273-278, 2009.
11. 2+ channel calmodulin-binding domains are 'auto-agonist' ligands in rabbit ventricular myocytes. J Physiol 550: 731-738, 2003.
12. Fatkin D, Christe ME, Aristizabal O, McConnell BK, Srinivasan S, Schoen FJ, Seidman CE, Turnbull DH, Seidman JG. Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the a cardiac myosin heavy chain gene. J Clin Invest 103: 147-153, 1999.
13. 2+] during inotropic interventions in isolated rat myocytes. J Physiol 437: 351-375, 1991.
14. Fu Y, Westenbroek RE, Yu FH, Clark JP, Marshall MR, Scheuer T, Catterall WA. Deletion of the distal C terminus of CaV1.2 channels leads to loss of fj-adrenergic regulation and heart failure in vivo. J Biol Chem 286: 12617-12626, 2011.
15. Fuller MD, Emrick MA, Sadilek M, Scheuer T, Catterall WA. Molecular mechanism of calcium channel regulation in the fight-or-flight response. Sci Signal 3: ra70, 2010.
16. Gao T, Cuadra AE, Ma H, Bunemann M, Gerhardstein BL, Cheng T, Eick RT, Hosey MM. C-terminal fragments of the alpha 1C (CaV1.2) subunit associate with and regulate L-type calcium channels containing C-terminal-truncated alpha 1C subunits. J Biol Chem 276: 21089-21097, 2001.
17. Gomez-Ospina N, Tsuruta F, Barreto-Chang O, Hu L, Dolmetsch R. The C terminus of the L-type voltage-gated calcium channel CaV1.2 encodes a transcription factor. Cell 127: 591-606, 2006.
18. Grandi E, Pasqualini FS, Bers DM. A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol 48: 112-121, 2010.
19. Green EL. Biology of the laboratory mouse. New York: Dover Publications, 1966.
20. Hohnloser SH, Woosley RL. Sotalol. N Engl J Med 331: 31-38, 1994.
21. Hulme JT, Konoki K, Lin TW, Gritsenko MA, Camp DG, 2nd Bigelow DJ, Catterall WA. Sites of proteolytic processing and nonco-valent association of the distal C-terminal domain of CaV1.1 channels in skeletal muscle. Proc Natl Acad Sci USA 102: 5274-5279, 2005.
22. Hulme JT, Yarov-Yarovoy V, Lin TW, Scheuer T, Catterall WA. Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain. J Physiol 576: 87-102, 2006.
23. Lester WC, Schroder EA, Burgess DE, Yozwiak D, Andres DA, Satin J. Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block. Cell Calcium 44: 353-362, 2008.
24. 2+ channels in cardiac and smooth muscles. Cardiovasc Res 68: 197-203, 2005.
25. Mikami A, Imoto K, Tanabe T, Niidome T, Mori Y, Takeshima H, Narumiya S, Numa S. Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature 340: 230-233, 1989.
26. Mikami A, Imoto K, Tanabe T, Niidome T, Mori Y, Takeshima H, Narumiya S, Numa S. Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature 340: 230-233, 1989.
27. Pang C, Crump SM, Jin L, Correll RN, Finlin BS, Satin J, Andres DA. Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation. Channels (Austin) 4: 192-202, 2010.
28. Perez-Reyes E, Castellano A, Kim HS, Bertrand P, Baggstrom E, Lacerda AE, Wei XY, Birnbaumer L. Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. J Biol Chem 267: 1792-1797, 1992.
29. 2+ -dependent inactivation of L-type calcium channels. Neuron 22: 549-558, 1999.
30. 2+ channels. J Biol Chem 276: 30794-30802, 2001.
31. Schroder E, Byse M, Satin J. L-type calcium channel C terminus autoregulates transcription. Circ Res 104: 1373-1381, 2009.
32. Schroder EA, Wei Y, Satin J. The developing cardiac myocyte: maturation of excitability and excitation-contraction coupling. Ann N Y Acad Sci 1080: 63-75, 2006.
33. Slish DF, Engle DB, Varadi G, Lotan I, Singer D, Dascal N, Schwartz A. Evidence for the existence of a cardiac specific isoform of the alpha 1 subunit of the voltage dependent calcium channel. FEBS Lett 250: 509-514, 1989.
34. Tang ZZ, Liang MC, Lu S, Yu D, Yu CY, Yue DT, Soong TW. Transcript scanning reveals novel and extensive splice variations in human L-type voltage-gated calcium channel, Cav1.2 a1 subunit. J Biol Chem 279: 44335-44343, 2004.
35. 2+/calmodulin complex. Nat Struct Mol Biol 12: 1108-1115, 2005.
36. Wahler GM, Dollinger SJ, Smith JM, Flemal KL. Time course of postnatal changes in rat heart action potential and in transient outward current is different. Am J Physiol Heart Circ Physiol 267: H1157-H1166, 1994.
37. Wang LJ, Sobie EA. Mathematical model of the neonatal mouse ventricular action potential. Am J Physiol Heart Circ Physiol 294: H2565-H2575, 2008.
38. 2+ channel activity by deletions at the carboxyl terminus of the cardiac alpha 1 subunit. J Biol Chem 269: 1635-1640, 1994.
39. Wu L, Ma J, Li H, Wang C, Grandi E, Zhang P, Luo A, Bers DM, Shryock JC, Belardinelli L. Late sodium current contributes to the reverse rate-dependent effect of Ikr inhibition on ventricular repolarization. Circulation 123: 1713-1720, 2011.