The lack of non-steroid isoprenoids causes oxidative stress in patients with mevalonic aciduria

Medical Hypotheses

Volumn 70, Issue 5, 2008, Pages 938-940

  Celec, Peter ^a,b   Behuliak, Michal ^a  

^a Faculty of Medicine of Comenius University and University Hospital Bratislava   (Slovakia)

^b Physics and Informatics   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CHOLESTEROL; DOLICHOL; GLUTATHIONE PEROXIDASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEVALONATE KINASE; MEVALONIC ACID; SELENOPROTEIN; UBIDECARENONE;

ACIDURIA; ARTICLE; CHOLESTEROL SYNTHESIS; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENETIC DISORDER; HUMAN; METABOLIC DISORDER; OXIDATIVE STRESS; PRIORITY JOURNAL; RHABDOMYOLYSIS;

ANTIOXIDANTS; CHOLESTEROL; GLUTATHIONE PEROXIDASE; GLYCOSYLATION; HUMANS; MEVALONATE KINASE DEFICIENCY; MODELS, BIOLOGICAL; MUTATION; NEURONS; OXIDATIVE STRESS; SELENOCYSTEINE; SELENOPROTEINS; TERPENES;

EID: 40849106973     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.08.030     Document Type: Article

References (9)

1. Houten S.M., Frenkel J., Rijkers G.T., Wanders R.J., Kuis W., and Waterham H.R. Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome. Hum Mol Genet 11 (2002) 3115-3124
2. Simon A., Cuisset L., Vincent M.F., van Der Velde-Visser S.D., Delpech M., van Der Meer J.W., et al. Molecular analysis of the mevalonate kinase gene in a cohort of patients with the hyper-igd and periodic fever syndrome: its application as a diagnostic tool. Ann Intern Med 135 (2001) 338-343
3. Simon A., Kremer H.P., Wevers R.A., Scheffer H., De Jong J.G., Van Der Meer J.W., et al. Mevalonate kinase deficiency: evidence for a phenotypic continuum. Neurology 62 (2004) 994-997
4. Houten S.M., Kuis W., Duran M., de Koning T.J., van Royen-Kerkhof A., Romeijn G.J., et al. Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome. Nat Genet 22 (1999) 175-177
5. Martinez-Botas J., Ferruelo A.J., Suarez Y., Fernandez C., Gomez-Coronado D., and Lasuncion M.A. Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives. Biochim Biophys Acta 1532 (2001) 185-194
6. Diomede L., Albani D., Sottocorno M., Donati M.B., Bianchi M., Fruscella P., et al. In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. Arterioscler Thromb Vasc Biol 21 (2001) 1327-1332
7. Wolfrum S., Jensen K.S., and Liao J.K. Endothelium-dependent effects of statins. Arterioscler Thromb Vasc Biol 23 (2003) 729-736
8. Moosmann B., and Behl C. Selenoprotein synthesis and side-effects of statins. Lancet 363 (2004) 892-894
9. Commans S., and Bock A. Selenocysteine inserting tRNAs: an overview. FEMS Microbiol Rev 23 (1999) 335-351