Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency

Inflammation Research

Volumn 59, Issue 5, 2010, Pages 335-338

  Marcuzzi, Annalisa ^a,b   Decorti, Giuliana ^a   Pontillo, Alessandra ^b   Ventura, Alessandro ^b   Tommasini, Alberto ^a,b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

Author keywords

Cholesterol; IL 1 ; Inflammation; Mevalonate kinase deficiency; Temperature

Indexed keywords

ALENDRONIC ACID; CHOLESTEROL; FARNESOL; GERANIOL; GERANYLGERANIOL; INTERLEUKIN 1BETA; ISOPRENOID; MURAMYL DIPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY TEMPERATURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; FOOD INTAKE; INFLAMMATION; MALE; MEVALONATE KINASE DEFICIENCY; MOUSE; NONHUMAN;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CHOLESTEROL; DISEASE MODELS, ANIMAL; INFLAMMATION; INTERLEUKIN-1BETA; MALE; MEVALONATE KINASE DEFICIENCY; MICE; MICE, INBRED BALB C; RANDOM ALLOCATION; TERPENES;

EID: 77953364021     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-010-0168-6     Document Type: Article

References (8)

1. Fears R. The contribution of the cholesterol biosynthetic pathway to intermediary metabolism and cell function. Biochem J. 1981;199:1-7.
2. Houten SM, Frenkel J, Waterham HR. Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. Cell Mol Life Sci. 2003;60:1118-1134
3. Frenkel J, Rijkers GT, Mandey SH, Buurman SW, Houten SM, Wanders RJ, et al. Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. Arthritis Rheum. 2002;46:2794-2803
4. Houten SM, Wanders RJ, Waterham HR. Biochemical and genetic aspects of mevalonate kinase and its deficiency. Biochim Biophys Acta. 2000;1529:19-32.
5. Marcuzzi A, Pontillo A, De Leo L, Tommasini A, Decorti G, Not T, et al. Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency. Pediatr Res. 2008;64:177-182
6. Newsom DM, Bolgos GL, Colby L, Nemzek JA. Comparison of body surface temperature measurement and conventional methods for measuring temperature in the mouse. Contemp Top Lab Anim Sci. 2004;43:13-18
7. Mandey SH, Kuijk LM, Frenkel J, Waterham HR. A role for geranylgeranylation in interleukin-1beta secretion. Arthritis Rheum. 2006;54:3690-3695
8. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860-867