Innate Immune signals in autoimmune and autoinflammatory uveitis

International Reviews of Immunology

Volumn 32, Issue 1, 2013, Pages 68-75

  Rosenbaum, James T ^a,b   Kim, Hyun Woong ^a,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b DEVERS EYE INSTITUTE   (United States)

^c Inje University College of Medicine   (South Korea)

Author keywords

Ankylosing spondylitis; Behcet's disease; Inflammatory bowel disease; NOD2; Sarcoidosis; TLR

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; HLA B27 ANTIGEN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

ADAPTIVE IMMUNITY; ANKYLOSING SPONDYLITIS; AUTOIMMUNE UVEITIS; AUTOINFLAMMATORY DISEASE; AUTOINFLAMMATORY UVEITIS; BEHCET DISEASE; BLAU SYNDROME; CELL LINEAGE; CELLULAR IMMUNITY; CINCA SYNDROME; CROHN DISEASE; ENTERITIS; FAMILIAL COLD AUTOINFLAMMATORY SYNDROME; GENETIC SUSCEPTIBILITY; GRAVES DISEASE; HUMAN; INFLAMMATORY DISEASE; INNATE IMMUNITY; INTESTINE FLORA; MUCKLE WELLS SYNDROME; MYASTHENIA GRAVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PSORIASIS; PSORIATIC ARTHRITIS; REACTIVE ARTHRITIS; REVIEW; RHEUMATOID ARTHRITIS; SARCOIDOSIS; SYSTEMIC LUPUS ERYTHEMATOSUS; TOXOPLASMA GONDII; ULCERATIVE COLITIS; UVEITIS;

ANIMALS; AUTOIMMUNITY; BEHCET SYNDROME; HUMANS; IMMUNITY, INNATE; INFLAMMATORY BOWEL DISEASES; MUTATION; SARCOIDOSIS; SIGNAL TRANSDUCTION; SPONDYLITIS, ANKYLOSING; TOLL-LIKE RECEPTORS; UVEITIS;

EID: 84873305114     PISSN: 08830185     EISSN: 15635244     Source Type: Journal    
DOI: 10.3109/08830185.2012.750132     Document Type: Review

References (54)

1. Hoffman HM, Mueller JL, Broide DH, et al. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 2001;29(3):301-305. (Pubitemid 33096455)
2. Miceli-Richard C, Lesage S, Rybojad M, et al. CARD15 mutations in Blau syndrome. Nat Genet 2001;29(1):19-20. (Pubitemid 32801800)
3. Aganna E, Martinon F, Hawkins PN, et al. Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum 2002;46(9):2445-2452.
4. Garcia-Ortiz H, Velazquez-Cruz R, Espinosa-Rosales F, et al. Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population. Ann Rheum Dis 2010;69(10):1861-1865.
5. O'Neill LA. Primer: toll-like receptor signaling pathways - what do rheumatologists need to know? Nat Clin Pract Rheumatol 2008;4(6):319-327. (Pubitemid 351791443)
6. Hugot JP, Chamaillard M, ZoualiH, et al. Association ofNOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411(6837):599-603. (Pubitemid 32531408)
7. ZhernakovaA, Festen EM, Franke L, et al.Genetic analysis of innateimmunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet 2008;82(5):1202-1210.
8. Pointon JJ,Harvey D, Karaderi T, et al. Elucidating the chromosome 9 association with AS; CARD9 is a candidate gene. Genes Immun 2010;11(6):490-496.
9. Abdollahi-Roodsaz S, Joosten LA, Koenders MI, et al. Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation. Am J Pathol 2009;175(5):2004-2013.
10. Watanabe T, Kitani A, Murray PJ, et al. Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 2006;25(3):473-485. (Pubitemid 44355006)
11. McGonagle D,McDermott MF. A proposed classification of the immunological diseases. PLoSMed 2006;3(8):e297.
12. Olszak T, An D, Zeissig S, et al.Microbial exposure during early life has persistent effects on natural killer T cell function. Science 2012;336(6080):489-493.
13. Friswell M, Campbell B, Rhodes J.The role of bacteria in the pathogenesis of inflammatory bowel disease. Gut Liver 2010;4(3):295-306.
14. Hand TW, Dos Santos LM, Bouladoux N, et al. Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses. Science 2012;337(6101):1553-1556.
15. Girardin SE, Boneca IG, Viala J, et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003;278(11):8869-8872. (Pubitemid 36800360)
16. Park JH,Kim YG,McDonaldC, et al. RICK/RIP2mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol 2007;178(4):2380-2386. (Pubitemid 46233437)
17. Teoh SC, Sharma S, Hogan A, et al. Tailoring biological treatment: anakinra treatment of posterior uveitis associated with the CINCA syndrome. Br J Ophthalmol 2007;91(2):263-264. (Pubitemid 46202883)
18. Aksentijevich I, Nowak M, Mallah M, et al. De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum 2002;46(12):3340-3348. (Pubitemid 35453546)
19. Hawkins PN,LachmannHJ, Aganna E,McDermottMF. Spectrumof clinical features inMuckle-Wells syndrome and response to anakinra. Arthritis Rheum 2004;50(2):607-612. (Pubitemid 38198844)
20. Quentin CD, Reiber H. Fuchs heterochromic cyclitis: rubella virus antibodies and genome in aqueous humor. AmJ Ophthalmol 2004;138(1):46-54. (Pubitemid 38850248)
21. Birnbaum AD, Tessler HH, Schultz KL, et al. Epidemiologic relationship between Fuchs heterochromic iridocyclitis and the United States Rubella Vaccination Program. Am J Ophthalmol 2007;144(3):424-428.
22. Henao-Mejia J, Elinav E, Jin C, et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012;482(7384):179-185.
23. Song Z, Marzilli L, Greenlee BM, et al. Mycobacterial catalase-peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis. J Exp Med 2005;201(5): 755-767. (Pubitemid 40395121)
24. Singh R, Toor P, Parchand S, et al. Quantitative polymerase chain reaction for Mycobacterium tuberculosis in so-called Eales' disease. Ocul Immunol Inflamm 2012;20(3):153-157.
25. Zeboulon N, Dougados M, Gossec L. Prevalence and characteristics of uveitis in the spondyloarthropathies: a systematic literature review. Ann Rheum Dis 2008;67(7):955-959. (Pubitemid 351956657)
26. RosenbaumJT, Rosenzweig HL. Spondyloarthritis: the eyes have it: uveitis in patients with spondyloarthritis. Nat Rev Rheumatol 2012;8(5):249-250.
27. Mielants H, Veys EM, Cuvelier C, et al. HLA-B27 related arthritis and bowel inflammation. Part 2. Ileocolonoscopy and bowel histology in patients with HLA-B27 related arthritis. J Rheumatol 1985;12(2):294-298. (Pubitemid 15025372)
28. Taurog JD, Richardson JA, Croft JT, et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J ExpMed 1994;180(6):2359-2364. (Pubitemid 24351619)
29. Breban M, Fern'andez-Sueiro JL, Richardson JA, et al. T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats. J Immunol 1996;156:794-803. (Pubitemid 26028940)
30. Fert I, Glatigny S, Poulain C, et al. Correlation between dendritic cell functional defect and spondylarthritis phenotypes in HLA-B27/HUMAN beta2-microglobulin-transgenic rat lines. Arthritis Rheum 2008;58(11):3425-3429.
31. Durrani K, Foster CS. Psoriatic uveitis: a distinct clinical entity? Am J Ophthalmol 2005;139(1):106-111. (Pubitemid 40094846)
32. McFadden JP, Baker BS, Powles AV, Fry L. Psoriasis and streptococci: the natural selection of psoriasis revisited. Br J Dermatol 2009;160(5):929-937.
33. Yanagihori H, Oyama N, Nakamura K, et al. Role of IL-12B promoter polymorphism in Adamantiades-Behcet's disease susceptibility: an involvement of Th1 immunoreactivity against Streptococcus sanguinis antigen. J Invest Dermatol 2006;126(7):1534-1540.
34. Lyons JL, RosenbaumJT. Uveitis associated with inflammatory bowel disease compared with uveitis associated with spondyloarthropathy. Arch Ophthalmol 1997;115:61-64. (Pubitemid 27034932)
35. Benoist C, Mathis D. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nat Immunol 2001;2(9):797-801.
36. Yu RK, Ariga T, Usuki S, Kaida K. Pathological roles of ganglioside mimicry in Guillain-Barre syndrome and related neuropathies. Adv ExpMed Biol 2011;705:349-365.
37. Lundberg K,WegnerN, Yucel-Lindberg T,Venables PJ. Periodontitis inRA - thecitrullinated enolase connection. Nat Rev Rheumatol 2010;6(12):727-730.
38. van der Heijden IM, Wilbrink B, Tchetverikov I, et al. Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arthritis Rheum 2000;43(3):593-598. (Pubitemid 30394951)
39. Cousins SW, RosenbaumJT, Guss RB, Egbert PR. Ocular albumin fluorophotometric quantitation of endotoxin-induced vascular permeability. Infect Immun 1982;36(2):730-736. (Pubitemid 12101904)
40. Neu N, Beisel KW, Traystman MD, et al. Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis. J Immunol 1987;138(8):2488-2492. (Pubitemid 17051821)
41. Rosenbaum JT,McDevitt HO, Guss RB, Egbert PR. Endotoxin-induced uveitis in rats as a model for human disease. Nature 1980;286:611-613. (Pubitemid 10015368)
42. Fox A, Hammer ME, Lill P, et al. Experimental uveitis. Elicited by peptidoglycan-polysaccharide complexes, lipopolysaccharide, andmuramyl dipeptide. Arch Ophthalmol 1984;102(7):1063-1067. (Pubitemid 14083491)
43. Rosenzweig H, Galster K, Planck S, Rosenbaum J. NOD1 expression in the eye and functional contribution to IL-1{beta} dependent ocular inflammation in mice. Invest Ophthalmol Vis Sci 2009;50(4):1746-1753.
44. Su SB, Silver PB, Grajewski RS, et al. Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity. J Immunol 2005;175(10):6303-6310. (Pubitemid 41598869)
45. Fang J, Fang D, Silver PB, et al. The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model. Invest Ophthalmol Vis Sci 2010;51(6):3092-3099.
46. Saraswathy S, Nguyen AM, Rao NA.The role of TLR4 in photoreceptor {alpha}A crystallin upregulation during early experimental autoimmuneuveitis. InvestOphthalmol Vis Sci 2010;51(7):3680-3686.
47. Wen L, Ley RE, Volchkov PY, et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 2008;455(7216):1109- 1113.
48. Berer K, Mues M, Koutrolos M, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 2011;479(7374):538-541.
49. Arnold IC, Dehzad N, Reuter S, et al. Helicobacter pylori infection prevents allergic asthma inmouse models through the induction of regulatory T cells. J Clin Invest 2011;121(8):3088-3093.
50. Vijay-Kumar M, Aitken JD, Carvalho FA, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010;328(5975):228-231.
51. Elinav E, Strowig T, Kau AL, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011;145(5):745-757.
52. Atarashi K, Tanoue T, ShimaT, et al. Induction of colonic regulatoryT cells by indigenous Clostridium species. Science 2011;331(6015):337-341.
53. Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci USA 2010;107(27):12204-12209.
54. Ebringer R. Acute anterior uveitis and faecal carriage of gram-negative bacteria. Br J Rheumatol 1988;27(Suppl 2):42-45.