The languages spoken in the water body (or the biological role of cyanobacterial toxins)

Frontiers in Microbiology

Volumn 3, Issue APR, 2012, Pages

  Kaplan, Aaron ^a   Harel, Moshe ^a   Kaplan Levy, Ruth N ^b   Hadas, Ora ^b   Sukenik, Assaf ^b   Dittmann, Elke ^c  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b ISRAEL OCEANOGRAPHIC AND LIMNOLOGICAL RESEARCH   (Israel)

^c UNIVERSITY OF POTSDAM   (Germany)

Author keywords

Aoa; Cylindrospermopsin; Cyr; Mcy; Microcystin

Indexed keywords

EID: 84873304817     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2012.00138     Document Type: Article

References (112)

1. Abraham, E. R. (1998). The generation of plankton patchiness by turbulent stirring. Nature 391, 577-580.
2. Agervald, A., Baebprasert, W., Zhang, X. H., Incharoensakdi, A., Lindblad, P., and Stensjo, K. (2010). The CyAbrB transcription factor CalA regulates the iron superoxide dismutase in Nostoc sp. strain PCC 7120. Environ. Microbiol. 12, 2826-2837.
3. Alexova, R., Haynes, P. A., Ferrari, B. C., and Neilan, B. A. (2011). Comparative protein expression in different strains of the bloom-forming cyanobacterium Microcystis aeruginosa. Mol. Cell. Proteomics 10, M1 10 003749.
4. Alfonso, M., Perewoska, I., and Kirilovsky, D. (2001). Redox control of ntcA gene expression in Synechocystis sp. PCC 6803: nitrogen availability and electron transport regulate the levels of the NtcA protein. Plant Physiol. 125,969-981.
5. Alster, A., Kaplan-Levy, R. N., Sukenik, A., and Zohary, T. (2010). Morphology and phylogeny of a non-toxic invasive Cylindrospermopsis raciborskii from a Mediterranean Lake. Hydrobiologia 639,115-128.
6. Annila, A., Lehtimaki, J., Mattila, K., Eriksson, J. E., Sivonen, K., Rantala, T. T., and Drakenberg, T. (1996). Solution structure of nodularin. An inhibitor of serine/threonine-specific protein phosphatases. J. Biol. Chem. 271,16695-16702.
7. Babica, P., Blaha, L., and Marsalek, B. (2006). Exploring the natural role of microcystins - a review of effects on photoautotrophic organisms. J. Phycol. 42, 9-20.
8. Bacsi, I., Vasas, G., Suranyi, G., Hamvas, M., Mathe, C., Toth, E., Grigorszy, L, Gaspar, A., Toth, S., and Borbely, G. (2006). Alteration of cylindros permopsin production in sulfate- or phosphate-starved cyanobacterium Aphanizomenon ovalisporum. FEMS Microbiol. Lett. 259, 303-310.
9. Ballot, A., Ramm, J., Rundberget, T., Kaplan-Levy, R. N., Hadas, O., Sukenik, A., and Wiedner, C. (2011). Occurrence of non-cylindrospermopsin-pro ducing Aphanizomenon ovalisporum and Anabaena bergii in Lake Kinneret (Israel). J. Plankton Res. 33, 1736-1746.
10. Banker, R., Carmeli, S., Hadas, O., Teltsch, B., Porat, R., and Sukenik, A. (1997). Identification of cylindrospermopsin in the cyanobacterium Aphanizomenon ovalisporum (Cyanophyceae) isolated from Lake Kinneret, Israel. J. Phycol. 33, 613-616.
11. Banker, R., Carmeli, S., Werman, M., Teltsch, B., Porat, R., and Sukenik, A. (2001). Uracil moiety is required for toxicity of the cyanobacterial hepatotoxin cylindrospermopsin. J. Toxicol. Environ. Health 62, 281-288.
12. Bar-Yosef, Y., Sukenik, A., Hadas, O., Viner-Mozzini, Y., and Kaplan, A. (2010). Enslavement in the water body by toxic Aphanizomenon ovalisporum, inducing alkaline phosphatase in phytoplanktons. Curr. Biol. 20, 1557-1561.
13. Botes, D. P., Tuinman, A. A., Wessels, P. L., Viljoen, C. C., Kruger, H., Williams, D. H., Santikarn, S., Smith, R. J., and Hammond, S. J. (1984). The structure of cyanoginosin-LA, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosa. J. Chem. Soc. Perkin Trans. I 1, 2311-2318.
14. Burford, M. A., and Davis, T. W. (2011). Physical and chemical processes promoting dominance of the toxic cyanobacterium Cylindrospermopsis raciborskii. Chin. J. Oceanol. Limnol. 29,883-891.
15. Burgoyne, D. L., Hemscheidt, T. K., Moore, R. E., and Runnegar, M. T. C. (2000). Biosynthesis of cylindrospermopsin, J. Org. Chem. 65, 152-156.
16. Carmichael, W. W. (1997). The cyanotoxins.Adv. Bot. Res. 9,211-256.
17. Christiansen, G., Fastner, J., Erhard, M., Borner, T., and Dittmann, E. (2003). Microcystin biosynthesis in Planktothrix: genes, evolution, and manipulation. J. Bacteriol. 185, 564-572.
18. Christiansen, G., Molitor, C., Philmus, B., and Kurmayer, R. (2008). Non-toxic strains of cyanobacteria are the result of major gene deletion events induced by a transposable element. Mol. Biol. Evol. 25, 1695-1704.
19. De Figueiredo, D. R., Goncalves, A. M. M., Castro, B. B., Goncalves, F., Pereira, M. J., and Correia, A. (2011). Differential inter- and intra-specific responses of Aphanizomenon strains to nutrient limitation and algal growth inhibition. J. Plankton Res. 33,1606-1616.
20. Dittmann, E., Neilan, B. A., and Borner, T. (2001). Molecular biology of peptide and polyketide biosynthesis in cyanobacteria. Appl. Microbiol. Biotechnol. 57,467-473.
21. Dittmann, E., Neilan, B. A., Erhard, M., von Doehren, H., and Boerner, T. (1997). Insertional mutagenesis of a peptide synthetase gene that is responsible for hepatotoxin production in the cyanobacterium Microcystis aeruginosa PCC 7806. Mol. Microbiol. 26, 779-787.
22. Dittmann, E., and Wiegand, C. (2006). Cyanobacterial toxins - occurrence, biosynthesis and impact on human affairs. Mol. Nutr. FoodRes. 50,7-17.
23. Dyble, J., Tester, P. A., and Litaker, R. W. (2006). Effects of light intensity on cylindrospermopsin production in the cyanobacterial HAB species Cylindrospermopsis raciborskii. Afr. J. Mar. Sci. 28,309-312.
24. Dziallas, C., and Grossart, H. P. (2011). Temperature and biotic factors influence bacterial communities associated with the cyanobacterium Microcystis sp. Environ. Microbiol. 13,1632-1641.
25. Engene, N., Choi, H., Esquenazi, E., Rottacker, E. C., Ellisman, M. H., Dorrestein, P. C., and Gerwick, W. H. (2011). Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya. Environ. Microbiol. 13,1601-1610.
26. Fastner, J., Erhard, M., and von Dohren, H. (2001). Determination of oligopeptide diversity within a natural population of Microcystis spp. (cyanobacteria) by typing single colonies by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Appl. Environ. Microbiol. 67, 5069-5076.
27. Froscio, S. M., Humpage, A. R., Burcham, P. C., and Falconer, I. R. (2001). Cellfree protein synthesis inhibition assay for the cyanobacterial toxin cylindrospermopsin. Environ. Toxicol. 16,408-412.
28. Gerbersdorf, S. U. (2006). An advanced technique for immunolabelling of microcystins in cryosectioned cells of Microcystis aeruginosa PCC 7806 (cyanobacteria), implementations of an experiment with varying light scenarios and culture densities. Toxicon 47, 218-228.
29. Ginn, H. P., Pearson, L. A., and Neilan, B. A. (2010). NtcA from Microcystis aeruginosa PCC 7806 is autoregulatory and binds to the microcystin promoter. Appl. Environ. Microbiol. 76, 4362-4368.
30. Griffiths, D. J., and Saker, M. L. (2003). The palm island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin. Environ. Toxicol. 18, 78-93.
31. Hadas, O., Pinkas, R., Delphine, E., Vardi, A., Kaplan, A., and Sukenik, A. (1999). Limnological and eco-physiological aspects of Aphanizomenon ovalisporum bloom in Lake Kinneret. J. Plankton Res. 21, 1439-1453.
32. Hadas, O., Pinkas, R., Malinsky-Roshansky, N., Shalev-Alon, G., Delphine, E., Berner, T., Sukenik, A., and Kaplan, A. (2002). Physiological variables determined under laboratory conditions may explain the bloom of Aphanizomenon ovalisporum in Lake Kinneret. Eur. J. Phycol. 37, 259-267.
33. Hawkins, P. R., Putt, E., Falconer, I., and Humpage, A. (2001). Phenotypical variation in a toxic strain of the phytoplankter, Cylindrospermopsis raciborskii (Nostocales, Cyanophyceae) during batch culture. Environ. Toxicol. 16,460-467.
34. Hesse, K., Dittmann, E., and Boerner, T. (2001). Consequence of impaired microcystin production for light-dependent growth and pigmentation of Microcystis aeruginosa PCC 7806. FEMS Microbiol. Ecol. 37, 39-43.
35. Humpage, A. R., Fenech, M., Thomas, P., and Falconer, I. R. (2000). Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin. Mutat. Res. 472, 155-161.
36. Humpage, A. R., Fontaine, F., Froscio, S., Burcham, P., and Falconer, I. R. (2005). Cylindrospermopsin genotoxicity and cytotoxicity: role of cytochrome P-450 and oxidative stress. J. Toxicol. Environ. Health A 68, 739-753.
37. Jahnichen, S., Ihle, T., Petzoldt, T., and Benndorf, J. (2007). Impact of inorganic carbon availability on microcystin production by Microcystis aeruginosa PCC 7806. Appl. Environ. Microbiol. 73, 6994-7002.
38. Jochimsen, E. M., Carmichael, W. W., An, J. S., Cardo, D. M., Cookson, S. T., Holmes, C. E., Antunes, M. B., de Melo Filho, D. A., Lyra, T. M., and Barreto, V. S. (1998). Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. N. Engl. J. Med. 338,873-878.
39. Jones, A. C., Monroe, E. A., Podell, S., Hess, W. R., Klages, S., Esquenazi, E., Niessen, S., Hoover, H., Rothmann, M., Lasken, R. S., Yates, J. R., Reinhardt, R., Kube, M., Burkart, M., Allen, E. E., Dorrestein, P. C., Gerwick, W. H., and Gerwick, L. (2011). Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc. Natl. Acad. Sci. U.S.A. 108,8815-8820.
40. Kaebernick, M., Dittmann, E., Boerner, T., and Neilan, B. A. (2002). Multiple alternate transcripts direct the biosynthesis of microcystin, a cyanobacterial nonribosomal peptide. Appl. Environ. Microbiol. 68, 449-455.
41. Kaebernick, M., Neilan, B. A., Boerner, T., and Dittmann, E. (2000). Light and the transcriptional response of the microcystin biosynthetic gene cluster. Appl. Environ. Microbiol. 66, 3387-3392.
42. Kaebernick, M., and Neilan, B. A. (2001). Ecological and molecular investigations of cyanotoxin production. FEMS Microbiol. Ecol. 35, 1-9.
43. Kehr, J. C., Zilliges, Y., Springer, A., Disney, M. D., Ratner, D. D., Bouchier, C., Seeberger, P. H., de Marsac, N. T., and Dittmann, E. (2006). A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa. Mol. Microbiol. 59, 893-906.
44. Kinnear, S. (2010). Cylindrospermopsin: a decade of progress on bioaccumulation research. Mar. Drugs 8, 542-564.
45. Li, R., Carmichael, W. W., Brittain, S., Eaglesham, G. K., Shaw, G. R., Mahakhant, A., Noparatnaraporn, N., Yongmanitchai, W., Kaya, K., and Watanabe, M. M. (2001). Isolation and identification of the cyanotoxin cylindrospermopsin and deoxy-cylindrospermopsin from a Thailand strain of Cylindrospermopsis raciborskii (cyanobacteria). Toxicon 39, 973-980.
46. Lieman-Hurwitz, J., Haimovich, M., Shalev-Malul, G., Ishii, A., Hihara, Y., Gaathon, A., Lebendiker, M., and Kaplan, A. (2009). A cyanobacterial AbrB-like protein affects the apparent photosynthetic affinity for CO2 by modulating low-CO2-induced gene expression. Environ. Microbiol. 11,927-936.
47. Liu, L., and Rein, K. S. (2010). New peptides isolated from lyngbya species: a review. Mar. Drugs 8,1817-1837.
48. Long, B. M., Jones, G. J., and Orr, P. T. (2001). Cellular microcystin content in N-limited Microcystis aeruginosa can be predicted from growth rate. Appl. Environ. Microbiol. 67, 278-283.
49. Lopez-Gomollon, S., Hernandez, J. A., Pellicer, S., Angarica, V. E., Peleato, M. L., and Fillat, M. F. (2007). Crosstalk between iron and nitrogen regulatory networks in Anabaena (Nos-toc) sp. PCC 7120, identification of overlapping genes in FurA and NtcA regulons. J. Mol. Biol. 374, 267-281.
50. Lukac, M., and Aegerter, R. (1993). Influence of trace-metals on growth and toxin production of Microcystis aeruginosa. Toxicon 31,293-305.
51. Martin-Luna, B., Sevilla, E., Hernandez, J. A., Bes, M. T., Fillat, M. E, and Peleato, M. L. (2006). Fur from Microcystis aeruginosa binds in vitro promoter regions of the microcystin biosynthesis gene cluster. Phytochemistry 67, 876-881.
52. Mazmouz, R., Chapuis-Hugon, F., Mann, S., Pichon, V., Mejean, A., and Ploux, O. (2010). Biosynthesis of cylindrospermopsin and 7-epicylindrospermopsin in Oscillatoria sp. strain PCC 6506, Identification of the cyr gene cluster and toxin analysis. Appl. Environ. Microbiol. 76, 4943-4949.
53. Mazmouz, R., Chapuis-Hugon, F., Pichon, V., Mejean, A., and Ploux, O. (2011). The last step of the biosynthesis of the cyanotoxins cylindrospermopsin and 7-epi-cylindrospermopsin is catalysed by CyrI, a 2-oxoglutarate-dependent iron oxygenase. Chembiochem 12, 858-862.
54. Mejean, A., Mazmouz, R., Mann, S., Calteau, A., Medigue, C., and Ploux, O. (2010). The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506 reveals several gene clusters responsible for the biosynthesis of toxins and secondary metabolites. J. Bacteriol. 192, 5264-5265.
55. Metcalf, J. S., Barakate, A., and Codd, G. A. (2004). Inhibition of plant protein synthesis by the cyanobacterial hepatotoxin, cylindrospermopsin. FEMS Microbiol. Lett. 235, 125-129.
56. Mihali, T. K., Kellmann, R., Muenchhoff, J., Barrow, K. D., and Neilan, B. A. (2008). Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis. Appl. Environ. Microbiol. 74, 716-722.
57. Moffitt, M. C., and Neilan, B. A. (2004). Characterization of the nodularin synthetase gene cluster and proposed theory of the evolution of cyanobacterial hepatotoxins. Appl. Environ. Microbiol. 70, 6353-6362.
58. Murphy, P. J., and Thomas, C. W. (2001). The synthesis and biological activity of the marine metabolite cylindrospermopsin. Chem. Soc. Rev. 30, 303-312.
59. Murray, S. A., Mihali, T. K., and Neilan, B. A. (2011). Extraordinary conservation, gene loss, and positive selection in the evolution of an ancient neurotoxin. Mol. Biol. Evol. 28,1173-1182.
60. Neilan, B. A., Pearson, L. A., Moffitt, M. C., Mihali, K. T., Kaebemick, M., Kellmann, R., and Pomati, E (2008). "The genetics and genomics of cyanobacterial toxicity," in Cyanobacterial Harmful Algal Blooms, State of the Science and Research Needs, Vol. 619, ed. H. K Hudnell (New York: Springer), 417-452.
61. Nishizawa, T., Asayama, M., Fujii, K., Harada, K., and Shirai, M. (1999). Genetic analysis of the peptide synthetase genes for a cyclic heptapeptide microcystin in Microcystis spp. J. Biochem. 126, 520-529.
62. Nishizawa, T., Ueda, A., Asayama, M., Fujii, K., Harada, K., Ochi, K., and Shirai, M. (2000). Polyketide synthase gene coupled to the peptide synthetase module involved in the biosynthesis of the cyclic heptapeptide microcystin. J. Biochem. 127, 779-789.
63. Ogawa, Y. (1988). Net increase rates and dynamics of phytoplankton populations under hypereutrophic and eutrophic conditions. Jpn. J. Limnol. 49,261-268.
64. Oliveira, P., and Lindblad, P. (2008). An AbrB-like protein regulates the expression of the bidirectional hydrogenase in Synechocystis sp. strain PCC 6803. J. Bacteriol. 190, 1011-1019.
65. Orchard, E. D., Webb, E. A., and Dyhrman, S. T. (2009). Molecular analysis of the phosphorus starvation response in Trichodesmium spp. Environ. Microbiol. 11, 2400-2411.
66. Orr, P. T., and Jones, G. J. (1998). Relationship between microcystin production and cell division rates in nitrogen-limited Microcystis aeruginosa cultures. Limnol. Oceanogr. 43, 1604-1614.
67. Paerl, H. W., and Huisman, J. (2009). Climate change, a catalyst for global expansion of harmful cyanobacterial blooms. Environ. Microbiol. Rep. 1,27-37.
68. Pearson, L., Hisbergues, M., Dittmann, E., Boerner, T., and Neilan, B. A. (2004). Inactivation of an ABC transporter, McyH, results in loss of microcystin production in the cyanobacterium Microcystis aeruginosa PCC 7806. Appl. Environ. Microbiol. 70, 6370-6378.
69. Pearson, L., Mihali, T., Moffitt, M., Kellmann, R., and Neilan, B. (2010). On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin. Mar. Drugs 8, 1650-1680.
70. Pflugmacher, S. (2002). Possible allelopathic effects of cyanotoxins, with reference to microcystin-LR, in aquatic ecosystems. Environ. Toxicol. 17,407-413.
71. Preussel, K., Stuken, A., Wiedner, C., Chorus, I., and Fastner, J. (2006). First report on cylindrospermopsin producing Aphanizomenon flosaquae (Cyanobacteria) isolated from two German lakes. Toxicon 47, 156-162.
72. Rantala, A., Fewer, D. P., Hisbergues, M., Rouhiainen, L., Vaitomaa, J., Borner, T., and Sivonen, K. (2004). Phylogenetic evidence for the early evolution of microcystin synthesis. Proc. Natl. Acad. Sci. U.S.A. 101, 568-573.
73. Rapala, J., Sivonen, K., Lyra, C., and Niemela, S.-I. (1997). Variation of microcystins, cyanobacterial hepatotoxins, in Anabaena spp. as a function of growth stimuli. Appl. Environ. Microbiol. 63,2206-2212.
74. Reisner, M., Carmeli, S., Werman, M., and Sukenik, A. (2004). The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice. Toxicol. Sci. 82, 620-627.
75. Rengefors, K., Ruttenberg, K. C., Haupert, C. L., Taylor, C., Howes, B. L., and Anderson, D. M. (2003). Experimental investigation of taxon-specific response of alkaline phosphatase activity in natural freshwater phytoplankton. Limnol. Oceanogr. 48, 1167-1175.
76. Rodelas, B., Lithgow, J. K., Wisniewski-Dye, F., Hardman, A., Wilkinson, A., Economou, A., Williams, P., and Downie, J. A. (1999). Analysis of quorumsensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae. J. Bacteriol. 181, 3816-3823.
77. Rohrlack, T., Dittmann, E., Boerner, T., and Christoffersen, K. (2001). Effects of cell-bound microcystins on survival and feeding of Daphnia spp. Appl. Environ. Microbiol. 67, 3523-3529.
78. Rohrlack, T., Dittmann, E., Henning, M., Borner, T., and Kohl, J. G. (1999). Role of microcystins in poisoning and food ingestion inhibition of Daphnia galeata caused by the cyanobacterium Microcystis aeruginosa. Appl. Environ. Microbiol. 65, 737-739.
79. Rouhiainen, L., Vakkilainen, T., Siemer, B. L., Buikema, W., Haselkorn, R., and Sivonen, K. (2004). Genes coding for hepatotoxic heptapeptides (microcystins) in the cyanobacterium Anabaena strain 90. Appl. Environ. Microbiol. 70, 686-692.
80. Runnegar, M., and Lu, S. (1994). The role of glutathione (Gsh) in the hepatotoxicity caused by the cyanobacterial alkaloid cylindrospermopsin (Cy). FASEBJ. 8, A419.
81. Runnegar, M. T., Kong, S. M., Zhong, Y. Z., and Lu, S. C. (1995). Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochem. Pharmacol. 49, 219-225.
82. Runnegar, M. T., Xie, C. Y., Snider, B. B., Wallace, G. A., Weinreb, S. M., and Kuhlenkamp, J. (2002). In vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues. Toxicol. Sci. 67,81-87.
83. Saker, M. L., and Griffiths, D. J. (2000). The effect of temperature on growth and cylindrospermopsin content of seven isolates of Cylindrospermopsis raciborskii (Nos-tocales, Cyanophyceae) from water bodies in northern Australia. Phycologia 39, 349-354.
84. Schatz, D., Keren, Y., Hadas, O., Carmeli, S., Sukenik, A., and Kaplan, A. (2005). Ecological implications of the emergence of non-toxic subcultures from toxic Microcystis strains. Environ. Microbiol. 7, 798-805.
85. Schatz, D., Keren, Y., Vardi, A., Sukenik, A., Carmeli, S., Boerner, T., Dittmann, E., and Kaplan, A. (2007). Towards clarification of the biological role of microcystins, a family of cyanobacterial toxins. Environ. Microbiol. 9, 965-970.
86. Schembri, M. A., Neilan, B. A., and Saint, C. P. (2001). Identification of genes implicatedin toxin production in the cyanobacterium Cylindrospermopsis raciborskii. Environ. Toxicol. 16,413-421.
87. Seifert, M., McGregor, G., Eaglesham, G., Wickramasinghe, W., and Shaw, G. (2007). First evidence for the production of cylindrospermopsin and deoxy-cylindrospermopsin by the freshwater benthic cyanobacterium, Lyngbya wollei (Farlow ex Gomont) Speziale and Dyck. Harmful Algae 6, 73-80.
88. Sevilla, E., Martin-Luna, B., Vela, L., Bes, M. T., Fillat, M. F., and Peleato, M. L. (2008). Iron availability affects mcyD expression and microcystin-LR synthesis in Microcystis aeruginosa PCC7806. Environ. Microbiol. 10,2476-2483.
89. Sevilla, E., Martin-Luna, B., Vela, L., Bes, M. T., Peleato, M. L., and Fillat, M. F. (2010). Microcystin-LR synthesis as response to nitrogen, transcriptional analysis of the mcyD gene in Microcystis aeruginosa PCC780. Ecotoxicology 19,1167-1173.
90. Shalev-Alon, G., Sukenik, A., Livnah, O., Schwarz, R., and Kaplan, A. (2002). A novel gene encoding amidinotransferase in the cylindrospermopsin producing cyanobacterium Aphanizomenon ovalisporum. FEMS Microbiol. Lett. 209,87-91.
91. Shen, X. Y., Lam, P. K. S., Shaw, G R., and Wickramasinghe, W. (2002). Genotoxicity investiga tion of a cyanobacterial toxin, cylindrospermopsin. Toxicon 40, 1499-1501.
92. Sivonen, K. (2008). "Emerging high throughput analyses of cyanobacterial toxins and toxic cyanobacteria," in Cyanobacterial Harmful Algal Blooms, State of the Science and Research Needs, Vol. 619, ed. H. K. Hudnell (New York: Springer), 539-557.
93. Sivonen, K., Carmichael, W .W., Namikoshi, M., Rinehart, K. L., Dahlem, A. M., and Niemela, S. I. (1990). Isolation and characterization of hepatotoxic microcystin homologs from the filamentous fresh-water cyanobacterium Nos-toc sp. strain-152. Appl. Environ. Microbiol. 56, 2650-2657.
94. Sivonen, K., and Jones, G. (1999). "Cyanobacterial toxins," in Toxic Cyanobacteria in Water, eds I. Chorus and J. Bartram (London: E & FN Spon), 41-111.
95. Straser, A., Filipic, M., and Zegura, B. (2011). Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line. Arch. Toxicol. 85,1617-1626.
96. Straub, C., Quillardet, P., Vergalli, J., Tandeau de Marsac, N., and Humbert, J.-F. (2011). A day in the life of Microcystis aeruginosa strain PCC 7806 as revealed by a transcriptomic analysis. PLoS ONE 6, e16208. doi: 10.1371/journal.pone.00 16208
97. Stuken, A., and Jakobsen, K. S. (2010). The cylindrospermopsin gene cluster of Aphanizomenon sp strain 10E6, organization and recombination. Microbiology 156, 2438-2451.
98. Sukenik, A., Beardall, J., and Hadas, O. (2007).Photosyntheticcharacterization of developing and mature akinetes of Aphanizomenon ovalisporum (Cyanoprokaryota). J. Phycol. 43, 780-788.
99. Tillett, D., Dittmann, E., Erhard, M., von Dohren, H., Borner, T., and Neilan, B. A. (2000). Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806, an integrated peptide- polyketide synthetase system. Chem. Biol. 7, 753-764.
100. Tonk, L., Visser, P. M., Christiansen, G., Dittmann, E., Snelder, E. O., Wiedner, C., Mur, L. R., and Huisman, J. (2005). The microcystin composition of the cyanobacterium Planktothrix agardhii changes toward a more toxic variant with increasing light intensity. Appl. Environ. Microbiol. 71, 5177-5181.
101. Utkilen, H., and Gjolme, N. (1992). Toxin production by Microcystis aeruginosa as a function of light in continuous cultures and its ecological significance. Appl Environ. Microbiol. 58, 1321-1325.
102. Van de Waal, D. B., Verspagen, J. M., Finke, J. F., Vournazou, V., Immers, A. K., Kardinaal, W. E., Tonk, L., Becker, S., Van Donk, E., Visser, P. M., and Huisman, J. (2011). Reversal in competitive dominance of a toxic versus non-toxic cyanobacterium in response to rising CO2. ISME J. 5, 1438-1450.
103. Vanderwesthuizen, A. J., and Eloff, J. N. (1985). Effect of temperature and light on the toxicity and growth of the blue-green-alga Microcystis aeruginosa (UV-006). Planta 163, 55-59.
104. Vezie, C., Rapala, J., Vaitomaa, J., Seitsonen, J., and Sivonen, K. (2002). Effect of nitrogen and phosphorus on growth of toxic and nontoxic Microcystis strains and on intracellular microcystin concentrations. Microb. Ecol. 43, 443-454.
105. Via-Ordorika, L., Fastner, J., Kurmayer, R., Hisbergues, M., Dittmann, E., Komarek, J., Erhard, M., and Chorus, I. (2004). Distribution of microcystin-producing and non-microcystin-producing Microcystis sp in European freshwater bodies: detection of microcystins and microcystin genes in individual colonies. Syst. Appl. Microbiol. 27, 592-602.
106. Walsby, A. E. (1997). Numerical integration of phytoplankton photosynthesis through time and depth in a water column. New Phytol. 136, 189-209.
107. Welker, M., and von Dohren, H. (2006). Cyanobacterial peptides -nature's own combinatorial biosynthesis. FEMS Microbiol. Rev. 30, 530-563.
108. Wiedner, C., Visser, P. M., Fastner, J., Metcalf, J. S., Codd, G. A., and Mur, L. R. (2003). Effects of light on the microcystin content of Microcystis strain PCC 7806. Appl. Environ. Microbiol. 69, 1475-1481.
109. Yamauchi, Y., Kaniya, Y., Kaneko, Y., and Hihara, Y (2011). Physiological roles of the cyAbrB transcriptional regulator pair Sll0822 and Sll0359 in Synechocystis sp. strain PCC 6803. J. Bacteriol. 193, 3702-3709.
110. Zegura, B., Straser, A., and Filipic, M. (2011). Genotoxicity and potential carcinogenicity of cyanobacterial toxins - a review. Mutat. Res. 727, 16-41.
111. Zilliges, Y., Kehr, J. C., Meissner, S., Ishida, K., Mikkat, S., Hagemann, M., Kaplan, A., Borner, T., and Dittmann, E. (2011). The cyanobacterial hepatotoxin microcystin binds to proteins andi increases the fitness of Microcystis under oxidative stress conditions. PLoS ONE 6, e1 7615. doi:10.1371/journal.pone. 0017615
112. Zilliges, Y., Kehr, J. C., Mikkat, S., Bouchier, C., de Marsac, N. T., Borner, T., and Dittmann, E. (2008). An extracellular glycoprotein is implicated in cell-cell contacts in the toxic cyanobacterium Microcystis aeruginosa PCC 7806. J. Bacteriol. 190, 2871-2879.