Inhibition and substrate activity of conformationally rigid vigabatrin analogues with γ-aminobutyric acid aminotransferase

Journal of Medicinal Chemistry

Volumn 42, Issue 22, 1999, Pages 4725-4728

  Qiu, Jian ^a   Pingsterhaus, Joyce M ^a   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 1 CYCLOPENTENE 1 CARBOXYLIC ACID; 4 AMINO 2 CYCLOPENTENE 1 CARBOXYLIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID DERIVATIVE; ANTICONVULSIVE AGENT; DEXTRO,LEVO AMINO 1 CYCLOPENTENE 1 CARBOXYLIC ACID; UNCLASSIFIED DRUG; VIGABATRIN;

ARTICLE; DRUG ACTIVITY; DRUG CONFORMATION; ENANTIOMER; ENZYME SPECIFICITY; EPILEPSY; KINETICS; REACTION ANALYSIS; STEREOCHEMISTRY;

4-AMINOBUTYRATE TRANSAMINASE; AMINO ACIDS; AMINO ACIDS, CYCLIC; CYCLOPENTANES; ENZYME INHIBITORS; KINETICS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; VIGABATRIN;

EID: 0033523938     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990271o     Document Type: Article

References (21)

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