RACK1 identified as the PCBP1-interacting protein with a novel functional role on the regulation of human MOR gene expression

Journal of Neurochemistry

Volumn 124, Issue 4, 2013, Pages 466-477

  Nahar Gohad, Pranjal ^a   Sultan, Hamidah ^a   Esteban, Ysabella ^a   Stabile, Alyda ^a   Ko, Jane L ^a  

^a SETON HALL UNIVERSITY   (United States)

Author keywords

expression modulation; hMOR gene; human NMB cells; PCBP1; physical interaction; RACK1

Indexed keywords

BINDING PROTEIN; MESSENGER RNA; MU OPIATE RECEPTOR; POLY C BINDING PROTEIN 1; RECEPTOR FOR ACTIVATED C KINASE 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOR GENE; NEUROBLASTOMA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REPORTER GENE;

CELL LINE, TUMOR; DIPRENORPHINE; GENE EXPRESSION REGULATION, NEOPLASTIC; GTP-BINDING PROTEINS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; IMMUNOPRECIPITATION; NARCOTIC ANTAGONISTS; NEOPLASM PROTEINS; NEUROBLASTOMA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RECEPTORS, OPIOID, MU; RNA, MESSENGER; RNA, SMALL INTERFERING; SEQUENCE DELETION; TRANSFECTION; TRITIUM;

EID: 84873290970     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12100     Document Type: Article

References (40)

1. Battaini F., Pascale A., Paoletti R., and, Govoni S., (1997) The role of anchoring protein rack1 in pkc activation in the ageing rat brain. Trends Neurosci. 20, 410-415.
2. Baumhaker Y., Ben-Dor T., Bar-Hamburger R., and, Sarne Y., (1994) Characterization of a triple opioid system in the human neuroblastoma NMB cell line. Brain Res. 665, 94-100.
3. Berry A. M., Flock K. E., Loh H. H., and, Ko J. L., (2006) Molecular basis of cellular localization of poly C binding protein 1 in neuronal cells. Biochem. Biophys. Res. Commun. 349, 1378-1386.
4. Buensuceso C. S., Woodside D., Huff J. L., Plopper G. E., and, O'Toole T. E., (2001) The WD protein Rack1 mediates protein kinase C and integrin-dependent cell migration. J. Cell Sci. 114, 1691-1698.
5. Chang B. Y., Conroy K. B., Machleder E. M., and, Cartwright C. A., (1998) RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells. Mol. Cell. Biol. 18, 3245-3256.
6. Chen S., Spiegelberg B. D., Lin F., Dell E. J., and, Hamm H. E., (2004) Interaction of G beta gamma with RACK1 and other WD40 repeat proteins. J. Mol. Cell. Cardiol. 37, 399-406.
7. Choe C., Im H. J., Ko J. L., and, Loh H. H., (1998) Mouse mu opioid receptor gene expression: a 34-bp cis-acting element inhibits transcription of the mu opioid receptor gene from the distal promoter. J. Biol. Chem. 273, 34926-34932.
8. Choi H. S., Hwang C. K., Kim C. S., Song K. Y., Law P. Y., Wei L. N., and, Loh H. H., (2005) Transcriptional regulation of mouse mu opioid receptor gene: Sp3 isoforms (M1, M2) function as repressors in neuronal cells to regulate the mu opioid receptor gene. Mol. Pharmacol. 67, 1674-1683.
9. Cloke B., Shah K., Kaneda H., et al,. (2010) The polyC-binding protein-1 regulates expression of the androgen receptor. Endocrinology 151, 3954-3964.
10. Cook R. J., Karch C., Nahar P., Rivera A., and, Ko J. L., (2010) Effects of desferoxamine-induced hypoxia on neuronal human mu-opioid receptor gene expression. Biochem. Biophys. Res. Commun. 398, 56-61.
11. Garcia-Higuera I., Gaitatzes C., Smith T. F., and, Neer E. J., (1998) Folding a WD repeat propeller. J. Biol. Chem. 273, 9041-9049.
12. Guillemot F., Billault A., and, Auffray C., (1989) Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex. Proc. Natl Acad. Sci. USA 86, 4594-4598.
13. Imai S. I., Yasuda S., Kai M., Kanoh H., and, Sakane F., (2009) Diacylglycerol kinase delta associates with receptor for activated C kinase 1, RACK1. Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1791, 246-253.
14. Julie L. K., Mark A. S., Stephen M. P., and, Mary C. B., (2007) Characterization of RACK1 function in drosophila development. Dev. Dyn. 236, 2207-2215.
15. Kang D. H., Song K. Y., Choi H. S., Law P. Y., Wei L. N., and, Loh H. H., (2012) Novel dual-binding function of a poly (C)-binding protein 3, transcriptional factor which binds the double-strand and single-stranded DNA sequence. Gene 501, 33-38.
16. Kiledjian M. D. C., Brewer G., and, Novick K., (1997) Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex. Mol. Cell. Biol. 17, 4870-4876.
17. Kim S. S., Pandey K. K., Choi H. S., Law P. Y., Wei L. N., and, Loh H. H., (2005) Poly C binding protein family is a transcription factor in mu-opioid receptor gene expression. Mol. Pharm. 68, 729-736.
18. Ko J. L., and, Loh H. H., (2001) Single-stranded DNA binding complex involved in transcriptional regulation of mouse mu-opioid receptor gene. J. Biol. Chem. 276, 788-795.
19. Ko J. L., and, Loh H. H., (2005) Poly C binding protein, a single-stranded DNA binding protein, regulates mouse mu-opioid receptor gene expression. J. Neurochem. 93, 749-761.
20. Ko J. L., Liu H. C., Minnerath S. R., and, Loh H. H., (1998) Transcriptional regulation of mouse mu-opioid receptor gene. J. Biol. Chem. 273, 27678-27685.
21. Ko J. L., Liu H. C., and, Loh H. H., (2003) Role of an AP-2-like element in transcriptional regulation of mouse mu-opioid receptor gene. Mol. Brain Res. 112, 153-162.
22. Lin Y. C., Flock K. E., Cook R. J., Hunkele A. J., Loh H. H., and, Ko J. L., (2008) Effects of trichostatin A on neuronal mu-opioid receptor gene expression. Brain Res. 1246, 1-10.
23. Makeyev A. V., and, Liebhaber S. A., (2002) The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. RNA 8, 265-278.
24. Malik A. K., Flock K. E., Godavarthi C. L., Loh H. H., and, Ko J. L., (2006) Molecular basis underlying the poly C binding protein 1 as a regulator of the proximal promoter of mouse mu-opioid receptor gene. Brain Res. 1112, 33-45.
25. McCahill A., Warwicker J., Bolger G. B., Houslay M. D., and, Yarwood S. J., (2002) The RACK1 scaffold protein: a dynamic cog in cell response mechanisms. Mol. Pharm. 62, 1261-1273.
26. Meng Q., Rayala S. K., Gururaj A. E., Talukder A. H., O'Malley B. W., and, Kumar R., (2007) Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1. Proc. Natl Acad. Sci. USA 104, 5866-5871.
27. Mochly-Rosen D., and, Gordon A. S., (1998) Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J. 12, 35-42.
28. Nakashima A., Chen L., Thao N. P., Fujiwara M., Wong H. L., Kuwano M., Umemura K., Shirasu K., Kawasaki T., and, Shimamoto K., (2008) RACK1 functions in rice innate immunity by interacting with the Rac1 immune complex. Plant Cell 20, 2265-2279.
29. Perera R., Daijogo S., Walter B. L., Nguyen J. H. C., and, Semler B. L., (2007) Cellular protein modification by poliovirus: the two faces of Poly(rC)-binding protein. J. Virol. 81, 8919-8932.
30. Rivera-Gines A., Cook R. J., Loh H. H., and, Ko J. L., (2006) Interplay of Sps and poly(C) binding protein 1 on the mu-opioid receptor gene expression. Biochem. Biophys. Res. Commun. 345, 530-537.
31. Ron D., Luo J., and, Mochly-Rosen D., (1995) C2 region-derived peptides inhibit translocation and function of protein kinase C in vivo. J. Biol. Chem. 270, 24180-24187.
32. Sklan E. H., Podoly E., and, Soreq H., (2006) RACK1 has the nerve to act: structure meets function in the nervous system. Prog. Neurobiol. 78, 117-134.
33. Sondek J., and, Siderovski D. P., (2001) Ggamma-like (ggl) domains: new frontiers in g-protein signaling and beta-propeller scaffolding. Biochem. Pharmacol. 61, 1329-1337.
34. Tcherkasowa A. E., Adam-Klages S., Kruse M. L., Wiegmann K., Mathieu S., Kolanus W., and, Krönke M, Adam D., (2002) Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor. J. Immunol. 169, 5161-5170.
35. Thakur S., Nakamura T., Calin G., et al,. (2003) Regulation of BRCA1 transcription by specific single-stranded DNA binding factors. Mol. Cell. Biol. 23, 3774-3787.
36. Walter B. L., Parsley T. B., Ehrenfeld E., and, Semler B. L., (2002) Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. J. Virol. 76, 12008-12022.
37. Zhang W., Zong C. S., Hermanto U., Lopez-Bergami P., Ze Ronai, and, Wang L. H., (2006) RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth. Mol. Cell. Biol. 26, 413-424.
38. Zhang B., Seitz S., Kusov Y., Zell R., and, Gauss-Müller V., (2007) RNA interaction and cleavage of poly(C)-binding protein 2 by hepatitis A virus protease. Biochem. Biophys. Res. Commun. 364, 725-730.
39. Zhang T., Huang X. H., Dong L., et al,. (2010) PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells. Mol. Cancer 9, 72.
40. Zhu J., and, Chen X., (2000) MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G2-M. Mol. Cell. Biol. 20, 5602-5618.