메뉴 건너뛰기




Volumn 4, Issue 1, 2013, Pages 41-52

nm23-H1 gene driven by hTERT promoter induces inhibition of invasive phenotype and metastasis of lung cancer xenograft in mice

Author keywords

Gene therapy; HTERT; Metastasis; Nm23 H1; Targeted gene expression

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; NUCLEOSIDE DIPHOSPHATE KINASE A; TELOMERASE REVERSE TRANSCRIPTASE;

EID: 84873285095     PISSN: 17597706     EISSN: 17597714     Source Type: Journal    
DOI: 10.1111/j.1759-7714.2012.00140.x     Document Type: Article
Times cited : (15)

References (55)
  • 1
    • 80455129249 scopus 로고    scopus 로고
    • Lung cancer: epidemiology, etiology, and prevention
    • Dela Cruz CS, Tanoue LT, Matthay RA. Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med 2011; 32: 605-44.
    • (2011) Clin Chest Med , vol.32 , pp. 605-644
    • Dela Cruz, C.S.1    Tanoue, L.T.2    Matthay, R.A.3
  • 2
    • 77952552230 scopus 로고    scopus 로고
    • Age, tumor size, type of surgery, and gender predict survival in early stage (stage I and II) non-small cell lung cancer after surgical resection
    • Agarwal M, Brahmanday G, Chmielewski GW, Welsh RJ, Ravikrishnan KP. Age, tumor size, type of surgery, and gender predict survival in early stage (stage I and II) non-small cell lung cancer after surgical resection. Lung Cancer 2010; 68: 398-402.
    • (2010) Lung Cancer , vol.68 , pp. 398-402
    • Agarwal, M.1    Brahmanday, G.2    Chmielewski, G.W.3    Welsh, R.J.4    Ravikrishnan, K.P.5
  • 4
    • 12444308291 scopus 로고    scopus 로고
    • Chemoradiotherapy for lung cancer: current status and perspectives
    • Ohe Y. Chemoradiotherapy for lung cancer: current status and perspectives. Int J Clin Oncol 2004; 9: 435-43.
    • (2004) Int J Clin Oncol , vol.9 , pp. 435-443
    • Ohe, Y.1
  • 5
    • 0023937268 scopus 로고
    • Evidence for a novel gene associated with low tumor metastatic potential
    • Steeg PS, Bevilacqua G, Kopper L etal. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 1988; 80: 200-4.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 200-204
    • Steeg, P.S.1    Bevilacqua, G.2    Kopper, L.3
  • 6
    • 0037264812 scopus 로고    scopus 로고
    • Metastasis suppressors alter the signal transduction of cancer cells
    • Steeg PS. Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer 2003; 3: 55-63.
    • (2003) Nat Rev Cancer , vol.3 , pp. 55-63
    • Steeg, P.S.1
  • 9
    • 0028957143 scopus 로고
    • Preferential reduction of nm23-H1 gene product in metastatic tissues from papillary and follicular carcinomas of the thyroid
    • Arai T, Yamashita T, Urano T etal. Preferential reduction of nm23-H1 gene product in metastatic tissues from papillary and follicular carcinomas of the thyroid. Mod Pathol 1995; 8: 252-6.
    • (1995) Mod Pathol , vol.8 , pp. 252-256
    • Arai, T.1    Yamashita, T.2    Urano, T.3
  • 10
    • 0027300389 scopus 로고
    • Immunohistochemical analysis of expression of nm23-H1/nucleoside diphosphate kinase in human thyroid carcinomas: lack of correlation between its expression and lymph node metastasis
    • Luo W, Matsuo K, Nagayama Y etal. Immunohistochemical analysis of expression of nm23-H1/nucleoside diphosphate kinase in human thyroid carcinomas: lack of correlation between its expression and lymph node metastasis. Thyroid 1993; 3: 105-9.
    • (1993) Thyroid , vol.3 , pp. 105-109
    • Luo, W.1    Matsuo, K.2    Nagayama, Y.3
  • 11
    • 0031771188 scopus 로고    scopus 로고
    • [Northern blot analysis of nm23 gene expression in human lung cancer
    • etal (In Chinese.)
    • Liu L, Qin Y, Zhou Qetal [Northern blot analysis of nm23 gene expression in human lung cancer. Chin J Oncol 1998; 20: 342-4. (In Chinese.).
    • (1998) Chin J Oncol , vol.20 , pp. 342-344
    • Liu, L.1    Qin, Y.2    Zhou, Q.3
  • 12
    • 33846458118 scopus 로고    scopus 로고
    • A study on the relationship between nm23-H1 gene expression and the prognosis in patients with non-small cell lung cancer
    • Chen XF, Zhou QH, Zhang SF etal. A study on the relationship between nm23-H1 gene expression and the prognosis in patients with non-small cell lung cancer. J Chin Exp Surg 2002; 19: 40-42.
    • (2002) J Chin Exp Surg , vol.19 , pp. 40-42
    • Chen, X.F.1    Zhou, Q.H.2    Zhang, S.F.3
  • 13
    • 1342315154 scopus 로고    scopus 로고
    • A study on the allelic deletion of nm23 genes in human lung cancer
    • Chen J, Zhou Q, Qin Y, Sun Z, Sun Z, Liu L. A study on the allelic deletion of nm23 genes in human lung cancer. Chin J Lung Cancer 2000; 3: 8-13.
    • (2000) Chin J Lung Cancer , vol.3 , pp. 8-13
    • Chen, J.1    Zhou, Q.2    Qin, Y.3    Sun, Z.4    Sun, Z.5    Liu, L.6
  • 14
    • 33846440126 scopus 로고    scopus 로고
    • Transfection of nm23-H1 increased expression of beta-Catenin, E-Cadherin and TIMP-1 and decreased the expression of MMP-2, CD44v6 and VEGF and inhibited the metastatic potential of human non-small cell lung cancer cell line L9981
    • Che GW, Chen J, Liu LX etal. Transfection of nm23-H1 increased expression of beta-Catenin, E-Cadherin and TIMP-1 and decreased the expression of MMP-2, CD44v6 and VEGF and inhibited the metastatic potential of human non-small cell lung cancer cell line L9981. Neoplasma 2006; 53: 530-7.
    • (2006) Neoplasma , vol.53 , pp. 530-537
    • Che, G.W.1    Chen, J.2    Liu, L.X.3
  • 15
    • 62349130927 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase (hTERT): a target molecule for the treatment of cisplatin-resistant tumors
    • Park YP, Kim KD, Kang SH etal. Human telomerase reverse transcriptase (hTERT): a target molecule for the treatment of cisplatin-resistant tumors. Korean J Lab Med 2008; 28: 430-7.
    • (2008) Korean J Lab Med , vol.28 , pp. 430-437
    • Park, Y.P.1    Kim, K.D.2    Kang, S.H.3
  • 16
    • 0347993974 scopus 로고    scopus 로고
    • [Establishment and their biological characteristics of clonal cell subpopulations (NL9980 and L9981) from a human lung large cell carcinoma cell line (WCQH-9801)]
    • In Chinese.)
    • Zhou QH, Wang YP, Che GW etal. [Establishment and their biological characteristics of clonal cell subpopulations (NL9980 and L9981) from a human lung large cell carcinoma cell line (WCQH-9801)]. Chin J Lung Cancer 2003; 6: 464-8. (In Chinese.).
    • (2003) Chin J Lung Cancer , vol.6 , pp. 464-468
    • Zhou, Q.H.1    Wang, Y.P.2    Che, G.W.3
  • 17
    • 0033082526 scopus 로고    scopus 로고
    • Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
    • Takakura M, Kyo S, Kanaya T etal. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res 1999; 59: 551-7.
    • (1999) Cancer Res , vol.59 , pp. 551-557
    • Takakura, M.1    Kyo, S.2    Kanaya, T.3
  • 18
    • 33947361619 scopus 로고    scopus 로고
    • Double mutant P96S/S120G of Nm23-H1 abrogates its NDPK activity and motility-suppressive ability
    • Zhou QH, Yang XQ, Zhu DX etal. Double mutant P96S/S120G of Nm23-H1 abrogates its NDPK activity and motility-suppressive ability. Biochem Biophys Res Commun 2007; 356: 348-53.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 348-353
    • Zhou, Q.H.1    Yang, X.Q.2    Zhu, D.X.3
  • 19
    • 13444278768 scopus 로고    scopus 로고
    • Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells
    • Salerno M, Palmieri D, Bouadis A, Halverson D, Steeg PS. Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells. Mol Cell Biol 2005; 25: 1379-88.
    • (2005) Mol Cell Biol , vol.25 , pp. 1379-1388
    • Salerno, M.1    Palmieri, D.2    Bouadis, A.3    Halverson, D.4    Steeg, P.S.5
  • 20
    • 0037115829 scopus 로고    scopus 로고
    • The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1
    • Du J, Hannon GJ. The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1. Nucleic Acids Res 2002; 30: 5465-75.
    • (2002) Nucleic Acids Res , vol.30 , pp. 5465-5475
    • Du, J.1    Hannon, G.J.2
  • 21
    • 0034715894 scopus 로고    scopus 로고
    • Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma
    • Roymans D, Willems R, Vissenberg K etal. Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma. Exp Cell Res 2000; 261: 127-38.
    • (2000) Exp Cell Res , vol.261 , pp. 127-138
    • Roymans, D.1    Willems, R.2    Vissenberg, K.3
  • 22
    • 43749094970 scopus 로고    scopus 로고
    • Alteration in gene expression profile and biological behavior in human lung cancer cell line NL9980 by nm23-H1 gene silencing
    • Ma W, Chen J, Xue X etal. Alteration in gene expression profile and biological behavior in human lung cancer cell line NL9980 by nm23-H1 gene silencing. Biochem Biophys Res Commun 2008; 371: 425-30.
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 425-430
    • Ma, W.1    Chen, J.2    Xue, X.3
  • 23
    • 33748110439 scopus 로고    scopus 로고
    • [Experimental study on molecular mechanism of nm23-HI gene transfection reversing the malignant phenotype of human high-metastatic large cell lung cancer cell line
    • In Chinese.)
    • Li Y, Zhou QH, Sun ZL etal. [Experimental study on molecular mechanism of nm23-HI gene transfection reversing the malignant phenotype of human high-metastatic large cell lung cancer cell line. Chin J Lung Cancer 2006; 9: 307-11. (In Chinese.).
    • (2006) Chin J Lung Cancer , vol.9 , pp. 307-311
    • Li, Y.1    Zhou, Q.H.2    Sun, Z.L.3
  • 24
    • 11144358143 scopus 로고    scopus 로고
    • [Experimental study of effects of nm23-HI gene transfection on the change of PKA activity in human high-metastasis large cell lung cancer cell line L9981
    • In Chinese)
    • Li DB, Zhou QH, Wang YP etal. [Experimental study of effects of nm23-HI gene transfection on the change of PKA activity in human high-metastasis large cell lung cancer cell line L9981. Chin J Lung Cancer 2004; 7: 91-4. (In Chinese).
    • (2004) Chin J Lung Cancer , vol.7 , pp. 91-94
    • Li, D.B.1    Zhou, Q.H.2    Wang, Y.P.3
  • 25
    • 4344569191 scopus 로고    scopus 로고
    • [Targeting blockage of Wnt signal transduction pathway of nm23-H1 gene transfection in human high-metastatic large cell lung cancer cell line L9981
    • In Chinese.)
    • Fu JK, Zhou QH, Zhu W etal. [Targeting blockage of Wnt signal transduction pathway of nm23-H1 gene transfection in human high-metastatic large cell lung cancer cell line L9981. Chin J Lung Cancer 2004; 7: 294-7. (In Chinese.).
    • (2004) Chin J Lung Cancer , vol.7 , pp. 294-297
    • Fu, J.K.1    Zhou, Q.H.2    Zhu, W.3
  • 26
    • 33645079435 scopus 로고    scopus 로고
    • [Effects of nm23-H1 point mutation on activity of GSK-3β in human high-metastatic large cell lung cancer cell line L9981
    • In Chinese.)
    • Ma L, Zhou QH, Zhu W etal. [Effects of nm23-H1 point mutation on activity of GSK-3β in human high-metastatic large cell lung cancer cell line L9981. Chin J Lung Cancer 2006; 9: 30-34. (In Chinese.).
    • (2006) Chin J Lung Cancer , vol.9 , pp. 30-34
    • Ma, L.1    Zhou, Q.H.2    Zhu, W.3
  • 27
    • 34848887610 scopus 로고    scopus 로고
    • [nm23-H1 gene inhibits lung cancer cell invasion through down-regulation of PKC signal pathway
    • In Chinese.)
    • Nie Q, Zhou QH, Zhu W etal. [nm23-H1 gene inhibits lung cancer cell invasion through down-regulation of PKC signal pathway. Chin J Oncol 2006; 28: 334-6. (In Chinese.).
    • (2006) Chin J Oncol , vol.28 , pp. 334-336
    • Nie, Q.1    Zhou, Q.H.2    Zhu, W.3
  • 28
    • 45349104921 scopus 로고    scopus 로고
    • Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1
    • Murakami M, Meneses PI, Knight JS etal. Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1. Int J Cancer 2008; 123: 500-10.
    • (2008) Int J Cancer , vol.123 , pp. 500-510
    • Murakami, M.1    Meneses, P.I.2    Knight, J.S.3
  • 29
    • 1942439051 scopus 로고    scopus 로고
    • [Regulation of nm232H1 transfection on expression of integrins in human high-metastasis large cell lung cancer cell line L9981
    • In Chinese.)
    • Zheng HX, Zhou QH, Sun ZL etal. [Regulation of nm232H1 transfection on expression of integrins in human high-metastasis large cell lung cancer cell line L9981. Chin J Lung Cancer 2004; 7: 108-11. (In Chinese.).
    • (2004) Chin J Lung Cancer , vol.7 , pp. 108-111
    • Zheng, H.X.1    Zhou, Q.H.2    Sun, Z.L.3
  • 30
    • 0347382319 scopus 로고    scopus 로고
    • nm23-H1 reduces in vitro cell migration and the liver metastatic potential of colon cancer cells by regulating myosin light chain phosphorylation
    • Suzuki E, Ota T, Tsukuda K etal. nm23-H1 reduces in vitro cell migration and the liver metastatic potential of colon cancer cells by regulating myosin light chain phosphorylation. Int J Cancer 2004; 108: 207-11.
    • (2004) Int J Cancer , vol.108 , pp. 207-211
    • Suzuki, E.1    Ota, T.2    Tsukuda, K.3
  • 32
    • 77949636388 scopus 로고    scopus 로고
    • hTERT-promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells
    • Onimaru M, Ohuchida K, Mizumoto K etal. hTERT-promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells. Cancer Sci 2010; 101: 735-42.
    • (2010) Cancer Sci , vol.101 , pp. 735-742
    • Onimaru, M.1    Ohuchida, K.2    Mizumoto, K.3
  • 33
    • 77956953248 scopus 로고    scopus 로고
    • Targeted antitumor effect induced by hTERT promoter mediated ODC antisense adenovirus
    • Wang W, Jin B, Li W etal. Targeted antitumor effect induced by hTERT promoter mediated ODC antisense adenovirus. Mol Biol Rep 2010; 37: 3239-47.
    • (2010) Mol Biol Rep , vol.37 , pp. 3239-3247
    • Wang, W.1    Jin, B.2    Li, W.3
  • 34
    • 68849101834 scopus 로고    scopus 로고
    • A novel hTERT promoter-driven E1A therapeutic for ovarian cancer
    • Xie X, Hsu JL, Choi MG etal. A novel hTERT promoter-driven E1A therapeutic for ovarian cancer. Mol Cancer Ther 2009; 8: 2375-82.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2375-2382
    • Xie, X.1    Hsu, J.L.2    Choi, M.G.3
  • 35
    • 60249099096 scopus 로고    scopus 로고
    • Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter
    • Fujiwara T, Tanaka N. Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter. Uirusu 2008; 58: 11-18.
    • (2008) Uirusu , vol.58 , pp. 11-18
    • Fujiwara, T.1    Tanaka, N.2
  • 36
    • 11244293562 scopus 로고    scopus 로고
    • Cloning of human telomerase catalytic subunit gene promoter and studying on its specific transcriptional activities in human lung cancer cell
    • In Chinese.)
    • Tang XJ, Wang YP, Zhou QH etal. Cloning of human telomerase catalytic subunit gene promoter and studying on its specific transcriptional activities in human lung cancer cell. Chin J Lung Cancer 2004; 7: 475-9. (In Chinese.).
    • (2004) Chin J Lung Cancer , vol.7 , pp. 475-479
    • Tang, X.J.1    Wang, Y.P.2    Zhou, Q.H.3
  • 37
    • 33846960757 scopus 로고    scopus 로고
    • hTERT/re-caspase-3 system induce apoptosis in hTERT-positive cancer cells
    • Yang LF, Zhao Y, Zeng L, Gong JP, Cao Y. hTERT/re-caspase-3 system induce apoptosis in hTERT-positive cancer cells. Cancer Biol Ther 2006; 5: 1546-53.
    • (2006) Cancer Biol Ther , vol.5 , pp. 1546-1553
    • Yang, L.F.1    Zhao, Y.2    Zeng, L.3    Gong, J.P.4    Cao, Y.5
  • 38
    • 0035422652 scopus 로고    scopus 로고
    • Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter
    • Komata T, Kondo Y, Kanzawa T etal. Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter. Cancer Res 2001; 61: 5796-802.
    • (2001) Cancer Res , vol.61 , pp. 5796-5802
    • Komata, T.1    Kondo, Y.2    Kanzawa, T.3
  • 39
    • 0034904662 scopus 로고    scopus 로고
    • FADD gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter to restrict induction of apoptosis to tumors in vitro and in vivo
    • Koga S, Hirohata S, Kondo Y etal. FADD gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter to restrict induction of apoptosis to tumors in vitro and in vivo. Anticancer Res 2001; 21: 1937-43.
    • (2001) Anticancer Res , vol.21 , pp. 1937-1943
    • Koga, S.1    Hirohata, S.2    Kondo, Y.3
  • 40
    • 0034575796 scopus 로고    scopus 로고
    • Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells
    • Abdul-Ghani R, Ohana P, Matouk I etal. Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells. Mol Ther 2000; 2: 539-44.
    • (2000) Mol Ther , vol.2 , pp. 539-544
    • Abdul-Ghani, R.1    Ohana, P.2    Matouk, I.3
  • 41
    • 6344247581 scopus 로고    scopus 로고
    • Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance
    • Dudognon C, Pendino F, Hillion J, Saumet A, Lanotte M, Ségal-Bendirdjian E. Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance. Oncogene 2004; 23: 7469-74.
    • (2004) Oncogene , vol.23 , pp. 7469-7474
    • Dudognon, C.1    Pendino, F.2    Hillion, J.3    Saumet, A.4    Lanotte, M.5    Ségal-Bendirdjian, E.6
  • 42
    • 80055009933 scopus 로고    scopus 로고
    • Targeting different types of human meningioma and glioma cells using a novel adenoviral vector expressing GFP-TRAIL fusion protein from hTERT promoter
    • Li JT, Bian K, Zhang AL etal. Targeting different types of human meningioma and glioma cells using a novel adenoviral vector expressing GFP-TRAIL fusion protein from hTERT promoter. Cancer Cell Int 2011; 11: 35-48.
    • (2011) Cancer Cell Int , vol.11 , pp. 35-48
    • Li, J.T.1    Bian, K.2    Zhang, A.L.3
  • 43
    • 32144434429 scopus 로고    scopus 로고
    • Enforced expression of a truncated form of Bax-alpha (tBax) driven by human telomerase reverse transcriptase (hTERT) promoter sensitizes tumor cells to chemotherapeutic agents or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    • Toyota H, Kondo S, Kyo S, Mizuguchi J. Enforced expression of a truncated form of Bax-alpha (tBax) driven by human telomerase reverse transcriptase (hTERT) promoter sensitizes tumor cells to chemotherapeutic agents or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Anticancer Res 2006; 26: 99-105.
    • (2006) Anticancer Res , vol.26 , pp. 99-105
    • Toyota, H.1    Kondo, S.2    Kyo, S.3    Mizuguchi, J.4
  • 44
    • 53349164750 scopus 로고    scopus 로고
    • [An experimental study on targeting suicide gene therapy for lung cancer with HSV-TK driven by hTERT promoter]
    • In Chinese.)
    • Wang YP, Tang XJ, Zhou QH, Che GW, Chen XH, Zhu DX. [An experimental study on targeting suicide gene therapy for lung cancer with HSV-TK driven by hTERT promoter]. Sichuan Da Xue Xue Bao Yi Xue Ban 2008; 39: 701-5. (In Chinese.).
    • (2008) Sichuan Da Xue Xue Bao Yi Xue Ban , vol.39 , pp. 701-705
    • Wang, Y.P.1    Tang, X.J.2    Zhou, Q.H.3    Che, G.W.4    Chen, X.H.5    Zhu, D.X.6
  • 45
    • 0036730025 scopus 로고    scopus 로고
    • Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter
    • Liu J, Zou WG, Lang MF etal. Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. Int J Oncol 2002; 21: 661-6.
    • (2002) Int J Oncol , vol.21 , pp. 661-666
    • Liu, J.1    Zou, W.G.2    Lang, M.F.3
  • 46
    • 0041883467 scopus 로고    scopus 로고
    • Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter
    • Takeda T, Inaba H, Yamazaki M etal. Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter. J Clin Endocrinol Metab 2003; 88: 3531-8.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3531-3538
    • Takeda, T.1    Inaba, H.2    Yamazaki, M.3
  • 47
    • 14644435646 scopus 로고    scopus 로고
    • Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line
    • Song JS, Kim HP. Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line. Oncol Rep 2004; 12: 443-7.
    • (2004) Oncol Rep , vol.12 , pp. 443-447
    • Song, J.S.1    Kim, H.P.2
  • 48
    • 39049179226 scopus 로고    scopus 로고
    • [Cloning of human telomerase reverse transcriptase promoter for targeted cancer therapy]
    • In Chinese.)
    • Li F, Tan XH, Peng XJ, Cai HB, Hu DR. [Cloning of human telomerase reverse transcriptase promoter for targeted cancer therapy]. Di Yi Jun Yi Da Xue Xue Bao 2005; 25: 207-11. (In Chinese.).
    • (2005) Di Yi Jun Yi Da Xue Xue Bao , vol.25 , pp. 207-211
    • Li, F.1    Tan, X.H.2    Peng, X.J.3    Cai, H.B.4    Hu, D.R.5
  • 49
    • 79955867288 scopus 로고    scopus 로고
    • Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects
    • Yu B, Zhang Y, Zhan Y etal. Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects. Oncol Rep 2011; 26: 255-64.
    • (2011) Oncol Rep , vol.26 , pp. 255-264
    • Yu, B.1    Zhang, Y.2    Zhan, Y.3
  • 50
    • 18044382167 scopus 로고    scopus 로고
    • Combination of caspase transfer using the human telomerase reverse transcriptase promoter and conventional therapies for malignant glioma cells
    • Takeuchi H, Kanzawa T, Kondo Y etal. Combination of caspase transfer using the human telomerase reverse transcriptase promoter and conventional therapies for malignant glioma cells. Int J Oncol 2004; 25: 57-63.
    • (2004) Int J Oncol , vol.25 , pp. 57-63
    • Takeuchi, H.1    Kanzawa, T.2    Kondo, Y.3
  • 51
    • 13444291202 scopus 로고    scopus 로고
    • Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter
    • Jacob D, Davis JJ, Zhang L, Zhu H, Teraishi F, Fang B. Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter. Cancer Gene Ther 2005; 12: 109-15.
    • (2005) Cancer Gene Ther , vol.12 , pp. 109-115
    • Jacob, D.1    Davis, J.J.2    Zhang, L.3    Zhu, H.4    Teraishi, F.5    Fang, B.6
  • 52
    • 0141632778 scopus 로고    scopus 로고
    • Combination of TRAIL gene therapy and chemotherapy enhances antitumor and antimetastasis effects in chemosensitive and chemoresistant breast cancers
    • Lin T, Zhang L, Davis J etal. Combination of TRAIL gene therapy and chemotherapy enhances antitumor and antimetastasis effects in chemosensitive and chemoresistant breast cancers. Mol Ther 2003; 8: 441-8.
    • (2003) Mol Ther , vol.8 , pp. 441-448
    • Lin, T.1    Zhang, L.2    Davis, J.3
  • 53
    • 0242538317 scopus 로고    scopus 로고
    • Xenoantigen, an alphaGal epitope-expression construct driven by the hTERT-promoter, specifically kills human pancreatic cancer cell line
    • Sawada T, Yamada O, Yoshimura N, Hatori K, Fuchinoue S, Teraoka S. Xenoantigen, an alphaGal epitope-expression construct driven by the hTERT-promoter, specifically kills human pancreatic cancer cell line. Cancer Cell Int 2002; 2: 14-20.
    • (2002) Cancer Cell Int , vol.2 , pp. 14-20
    • Sawada, T.1    Yamada, O.2    Yoshimura, N.3    Hatori, K.4    Fuchinoue, S.5    Teraoka, S.6
  • 54
    • 0347356413 scopus 로고    scopus 로고
    • hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin
    • Nakamura M, Kyo S, Kanaya T etal. hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin. Cancer Gene Ther 2004; 11: 1-7.
    • (2004) Cancer Gene Ther , vol.11 , pp. 1-7
    • Nakamura, M.1    Kyo, S.2    Kanaya, T.3
  • 55
    • 4644236049 scopus 로고    scopus 로고
    • Activity of the human telomerase catalytic subunit (hTERT) gene promoter could be increased by the SV40 enhancer
    • Song JS. Activity of the human telomerase catalytic subunit (hTERT) gene promoter could be increased by the SV40 enhancer. Biosci Biotechnol Biochem 2004; 68: 1634-9.
    • (2004) Biosci Biotechnol Biochem , vol.68 , pp. 1634-1639
    • Song, J.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.