Experimental study of effects of nm23-H1 gene transfection on the change of PKA activity in human high-metastasis large cell lung cancer cell line L9981

Chinese Journal of Lung Cancer

Volumn 7, Issue 2, 2004, Pages 91-94

  Li, Dingbiao ^a   Zhou, Qinghua ^a   Wang, Yanping ^a   Zhu, Wen ^a   Chen, Xiaohe ^a   Yang, Junjie ^a   Liu, Lunxu ^a   Fu, Junke ^a   Nie, Qiang ^a   Li, Yin ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Human high metastasis large cell lung cancer cell line L9981 Signal transduction; nm23 H1; PKA

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME ACTIVATOR; FORSKOLIN; NUCLEOSIDE DIPHOSPHATE KINASE A;

ARTICLE; CANCER CELL CULTURE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG CANCER; RADIOIMMUNOLOGY; TUMOR SUPPRESSOR GENE;

EID: 11144358143     PISSN: 10093419     EISSN: 19996187     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Hartsough MT, Steeg PS. Nm23-H1: genetic alterations and expression patterns in tumor metastasis. Am J Hum Genet, 1998, 63 (1): 6-10.
2. Kim SY, Ferrell JE Jr, Chae SK, et al. Inhibition of progesterone-induced xenopus oocyte maturation by Nm23. Cell Growth Differ, 2000, 11(9): 486-490.
3. Walsh DA, Van Patten SM. Multiple pathway signal transduction by the cAMP-dependent protein kinase. FASEB, 1994, 8(15): 1227-1236.
4. Bossemeyer D. Protein kinases - structure and function. FEBS Lett, 1995, 369(1); 57-61.
5. Raghunandan R, Ingram VM. Hyperphosphorylation of the cytoskeletal protein Tau by the MAPK PK40erk2: regulation by prior phosphorylation with cAMP-dependent protein kinase A. Biochem Biophys Res Commun, 1995, 215(3): 1056-1066.
6. Zhou QH, Wang YP, Che GW, et al. Establishment and their biological characteristic of clonal cell subpopulations (NL9980 and L9981) from a human large cell lung cancer cell line (WCQH-9801). Chin J Lung cancer, 2003, 6(6): 141-143.
7. Steeg PS, Bevilacqua G, Kopper L, et al. Evidence for a novel gene associated with low metastatic potential. J Natl Cancer Inst, 1988, 80(3): 200-204.
8. Chen XF, Zhou QH, Shi YK, et al. Study on expression of metastatic suppression gene of nm23-H1 in human non-small-cell lung cancer. Chin J Clin Thorac Cardiovasc Surg, 1997, 4(2): 80-82.
9. Zhou QH, Che GW, Qin Y, et al. Experimental study on nm-23-H1 gene reversing phenotype of lung cancer and its molecular mechanism. Chin J lung Cancer, 2003, 6(2): 141-143.
10. Kimura N, Shimada N. Membrane-associated nucleoside diphosphate kinase from rat liver. Purification, characterization, and comparison with cytosolic enzyme. J Biol Chem, 1988, 263(10): 4647-4653.
11. Chen TC, Hinton DR, Zidovetzk R, et al. Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab Invest, 1998, 78(2): 165-174.
12. Zhou T, Wang DS. The effect of cAMP on expression of several genes and CREB DNA binding activity in transformed C3H10T1/2 cells. Chin J Biochem Mol Biol, 2001, 17(1): 91-97.