Tinospora cordifolia: A Climbing shrub in health care management

International Journal of Pharma and Bio Sciences

Volumn 3, Issue 4, 2012, Pages 612-628

  Pandey, Mukeshwar ^a   Chikara, Surendra K ^a   Vyas, Manoj K ^a   Sharma, Rohit ^b   Thakur, Gulab S ^b   Bisen, P S ^c  

^a Xcelris Genomics   (India)

^b Tropilite Foods Pvt Ltd   (India)

^c DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Anti tumor; Climbing shrub; Cordifolide; Immunomodulation; Tinospora cordifolia; Tinosporine

Indexed keywords

3 (ALPHA,4 DIHYDROXY 3 METHOXYBENZYL) 4 (4 HYDROXY 3 METHOXYBENZYL)TETRAHYDROFURAN; ACETOACETIC ACID; ACETYLSALICYLIC ACID; ALIPHATIC COMPOUND; ALKALOID; ANTIULCER AGENT; CHLOROQUINE; CORDIFELONE; CORDIFOL; DITERPENOID; GILOIN; GILOININ; GLIBENCLAMIDE; GLYCOSIDE; HERBACEOUS AGENT; HIMOLIV; INDOMETACIN; INSULIN; JATRORRHIZINE; LACTONE; LIVER PROTECTIVE AGENT; PEPTICARE; PLACEBO; PLANT MEDICINAL PRODUCT; STEROID; TINOSPORA CORDIFOLIA EXTRACT; TINOSPORIC ACID; TINOSPORIDINE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AEROMONAS HYDROPHILA; ALLERGIC RHINITIS; AMNESIA; ANEMIA; ANTIANGIOGENIC ACTIVITY; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOSTEOPOROTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTITUBERCULOSIS ACTIVITY; ARTHRITIS; ARTICLE; AYURVEDA; BARK; BILIARY TRACT DISEASE; CANCER CHEMOTHERAPY; CHRONIC OTITIS MEDIA; CONCENTRATION RESPONSE; CONSTIPATION; DIABETES MELLITUS; DISEASE ASSOCIATION; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG FATALITY; DRUG INDICATION; DRUG SAFETY; DRUG TOLERABILITY; ENTEROPATHY; ERYSIPELAS; GOUT; GRAM NEGATIVE INFECTION; HEALTH CARE MANAGEMENT; HEART INFARCTION SIZE; HEART PROTECTION; HEPATITIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPER REACTIVE MALARIOUS SPLENOMEGALY; IMMUNOMODULATION; IMMUNOSTIMULATION; INTESTINE OBSTRUCTION; JAUNDICE; LEPROSY; LIVER DISEASE; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALARIA; MOUTH SQUAMOUS CELL CARCINOMA; MYCOBACTERIUM TUBERCULOSIS; NEPHROLITHIASIS; NONHUMAN; OSTEOPOROSIS; PHYTOCHEMISTRY; PLANT LEAF; PLANT ROOT; PLANT STEM; RADIATION INJURY; RADIATION PROTECTION; RHEUMATIC DISEASE; SCABIES; SHRUB; SKIN DISEASE; TREATMENT DURATION; ULCER; UPPER RESPIRATORY TRACT INFECTION; URINARY TRACT DISEASE; WOUND HEALING;

EID: 84873269637     PISSN: None     EISSN: 09756299     Source Type: Journal    
DOI: None     Document Type: Article

References (83)

1. Bishayi B, Roychowdherry S, Ghosh S, Sengupta M, Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats. J Toxicol Sci., 27 (3): 139-146, (2002).
2. Singh N, Singh SM, Shrivastava P, Efect of Tinospora cordifolia on the anti-tumor activity of tumor-associated macrophages derived dendrite cells. Immunopharmacol. Immunotoxicol., 27(1): 1-14, (2005).
3. Singh SS, Pandey SC, Srisvastava S, Gupta VS, Patro B, Ghosh AC, Chemistry and Medicinal properties of Tinospora cordifolia (Guduchi). Ind J Pharmacol., 35: 83-91, (2003).
4. Zhao TF, Wang X, Rimando AM, Che C, Folkloric medicinal plants: Tinospora sagittata var. cravaniana and Mahonia bealei. Planta Med., 57 (5): 505-507, (1991).
5. Rao EV, Rao MV, Studies on the polysaccharide preparation (Guduchi satwa) derived from Tinospora cordifolia. Indian J Pharm. Sci., 43: 103-106, (1981).
6. Chintalwar G, Jain A, Sipahimalani A, Banerji A, Sumariwalla P, Ramakrishnan R, Sainis K, An immunologically active arabinogalactan from Tinospora cordifolia. Phytochem., 52 (6): 1089-1093, (1999).
7. Gangan VD, Pradhan P, Sipahimalani AT, Phytoecdysones from Tinospora cordifolia: structural elucidation of ecdysterone and makisterone A by 2D NMR spectroscopy. Ind. J Chem., 29(17): 787-792, (1998).
8. Sarma DNK, Khosa RL, Sahai M, Isolation of Jatrorrhizine from Tinospora cordifolia Roots. Planta Med., 61 (1): 98-99, (1995).
9. Sarma DNK, Padma P, Khosa RL, Constituents of Tinospora cordifolia root. Fitoterapia, 69(6): 541-542, (1998).
10. Sarma DNK, Koul S, Khosa RL, Alkaloids from Tinospora cordifolia Miers. J Pharm. Sci. & Res., 1(1): 26-27, (2009)
11. Kiem PV, Minh CV, Dat NT, Kinh LV, Hang DT, Nam NH, Cuong NX, Huong HT, Lau TV, Aporphine alkaloids, clerodane diterpenes, and other constituents from Tinospora cordifolia. Fitoterapia, 81 (6): 485-489, (2010).
12. Kumar S, Verma NS, Pande D, Srivastava PS, In vitro regeneration and screening of berberine in Tinospora cordifolia. J Med. Arom. Plant Sci., 22, 61, (2000).
13. Ho YT, Yang JS, Lu CC, Chiang JH, Li TC, Lin JJ, Lai KC, Liao CL, Lin JG, Chung JG, Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model. Phytomed.,16(9): 887-890, (2009).
14. Fukuda N, Yonemitsu M, Kimura T, Studies on the Constituents of the Stems of Tinospora tuberculata, IV. Isolation and Structure Elucidation of the Five New Furanoid Diterpene Glycosides Borapetoside C-G. Liebigs Ann. Chem., 0(5): 491-495, 1993.
15. Martin TS, Ohtani K, Kasai R, Yamasaki K, Furanoid Diterpene Glucosides from Tinospora rumphii. Phytochem., 42 (1: 153-158, (1996).
16. Pis J, Budesinsky M, Vokac K, Laudova V, Harmatha J, Ecdysteroids from the roots of Leuzea carthamoides. Phytochem., 37 (3): 707-711, 1994.
17. Cavin A, Hostettmann K, DyatmykoW, Potterat O, Antioxidant and lipophilic constituents of Tinospora crispa (Menispermaceae Planta Med., 64 (5): 393-396, (1998).
18. Inoshiri S, Sasaki M, Kohda H, Otsuka H, Yamasaki K, Aromatic glycosides from Berchemia racemosa. Phytochem., 26 (10): 2811-2814, (1987).
19. Konishi T, Wada S, Kiyosawa S, Constituents of the leaves of Daphne pseudo-mezereum.Yakugaku Zasshi J. Pharm. Soc. Jap., 113 (9): 670-675, (1993).
20. Gangan VD, Pradhan P, Sipahimalani AT, Banerji A, Cordifolisides A, B, C: norditerpene furan glycosides from Tinospora cordifolia. Phytochem., 37 (3): 781-786, (1994).
21. Maurya R, Manhas LR, Gupta P, Mishra PK, Singh G, Yadav PP, Amritosides A, B, C and D: clerodane furano diterpene glucosides from Tinospora cordifolia. Phytochem., 65 (14): 2051-2055, (2004).
22. Wazir V, Maurya R, Kapil RS, Cordioside, a clerodane furano diterpene glucoside from Tinospora cordifolia. Phytochem., 38 (2): 447-449, (1995).
23. Maurya R, Wazir V, Tyagi A, Kapil RS, Clerodane diterpenoids from Tinospora cordifolia. Phytochem., 38 (3): 659-661, (1995).
24. Iqbal J, Husain A, Gupta A, Sensitized Photooxygenation of Tinosponone, a Clerodane Diterpene from Tinospora Cordifolia Acta Chim. Slov., 52 (4): 455-459, (2005).
25. Bhatt RK, Hanuman JB, Sabata BK, A new clerodane derivative from Tinospora cordifolia. Phytochem., 27 (4): 1212-1216, (1988).
26. Swaminathan K, Sinha UC, Bhatt RK, Sabata BK, Tavale SS. Structure of tinosporide, a diterpenoid furanolactone from Tinospora cordifolia Miers. Acta Crystallogr. C., 5(45): 134-136, (1989).
27. Dixit SN, Khosa RL, Chemical investigation of Tinospora cordifolia. Indian J. Appl. Chem., 34 (1): 46-47, (1971).
28. Khaleque A, Miah MAW, Huq MS, Abdul BK, Tinospora cordifolia. IV. Isolation of heptacosanol, b -sitosterol and three other compounds tinosporidine, cordifol and cordifolone. Pak. J. Sci. Ind. Res., 14: 481-483, (1971).
29. Chatterjee A, Ghosh S, Tinosporin, the furanoid bitter principle of Tinospora cordifolia. Sci. and Culture, 26: 140-141, (1960).
30. Thakur GS, Bag M, Sanodiya BS, Debnath M, Zacharia A, Bhadouriya P, Prasad GBKS, Bisen PS, Chlorophytum borivilianum: A White Gold for Biopharmaceuticals and Neutraceuticals. Curr. Pharm. Biotechnol. 10(7): 650-666, (2009).
31. Thakur GS, Bag M, Sanodiya BS, Debnath M, Bhadouriya P, Prasad GBKS, Bisen PS, Momordica balsamina- A Medicinal and Neutraceutical Plant for Health Care Management. Curr. Pharm. Biotechnol. 10(7): 667-682, (2009).
32. Sanodiya BS, Thakur GS, Baghel RK, Prasad GBKS, Bisen PS, Ganoderma lucidum: A Potent Pharmacological Macrofungi. Curr. Pharm. Biotechnol., 10(8): 717-742, (2009).
33. Bisen PS, Sanodiya BS, Baghel RK, Thakur GS, Prasad GBKS, Lentinus edodes: A Macrofungus with Pharmacological Activities. Curr. Med. Chem., 17 (22): 2419-30, (2010).
34. Kalikar MV, Thawani VR, Varadpande UK, Sontakke SD, Singh RP, Khiyani RK, Immunomodulatory effect of Tinospora cordifolia extract in human immunodeficiency virus positive patients. Indian J. Pharmacol., 40(3):107-110, (1998).
35. Sudhakaran DS, Srirekha P, Devasree LD, Premshingh S, Michael RD, Immunostimulatory effect of Tinospora cordifolia Miers leaf extract in Oreochromis mossambicus. Indian J. Exp. Bio., 44 (9): 726-732, (2006).
36. Raghu R, Sharma D, Ramakrishnan R, Khanam S, Chintalwar GJ, Sainis KB, Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia. Immunol. Lett., 123 (1): 60-71, (2009).
37. Ranjith MS, Ranjitsingh AJA, Shankar SG, Vijayalaksmi GS, Deepa K, Sidhu HS, Enhanced Phagocytosis and Antibody Production by Tinospora cordifolia - A new dimension in Immunomodulation. Afr. J. Biotechnol., 7(2): 81-85, (2008).
38. Desai VR, Ramkrishnan R, Chintalwar GJ, Sainis KB, G1-4A, an immunomodulatory polysaccharide from Tinospora cordifolia, modulates macrophage responses and protects mice against lipopolysaccharide induced endotoxic shock. Int. Immunopharmacol., 7 (10): 1375-1386, (2007).
39. Nair PKR, Rodrigueza S, Ramachandrana R, Alamoa A, Melnicka SJ, Escalona E, Garcia PI, Wnukb SF, Ramachandrana C, Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int. Immunopharmacol. 4, 1645-1659, (2004).
40. Nair PKR, Melnick SJ, Ramachandran R, Escalon E, Ramachandran C, Mechanism of macrophage activation by (1,4)-a-Dglucan isolated from Tinospora cordifolia. Int. Immunopharmacol., 6(12): 1815-1824, (2006).
41. Desai VR, Kamat JP, Sainis KB, An immunomodulator from Tinospora cordifolia with antioxidant activity in cellfree systems Proc. Indian Acad. Sci. (Chem. Sci.), 114(6): 713-719, (2002).
42. Kapil A, Sharma S, Immunopotentiating compounds from Tinospora cordifolia. J. Ethnopharmacol. 58 (2): 89-95, (1997).
43. Bansal P, Das SN, Study of antiproliferative activity of Tinosporacordifolia extracts in normal and malignant cells. J Pharmacy Res., 3(2): 382-385, (2010).
44. Singh SM, Singh N, Shrivastava P, Effect of alcoholic extract of Ayurvedic herb Tinospora cordifolia on the proliferation and myeloid differentiation of bone marrow precursor cells in a tumor-bearing host. Fitoterapia, 77 (1): 1-11, (2006)
45. Thippeswamy G, Salimath BP, Induction of caspase-3 activated DNase mediated apoptosis by hexane fraction of Tinospora cordifolia in EAT cells. Environ. Toxicol. Pharmacol., 23 (2): 212-220, (2007).
46. Leyon PV, Kuttan G, Inhibitory effect of a polysaccharide from Tinospora cordifolia on experimental metastasis. J. Ethnopharmacol. 90 (2-3): 233-237, (2004).
47. Jagetia GC, Rao SK, Evaluation of Cytotoxic Effects of Dichloromethane Extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on Cultured HeLa Cells. Evid. Based Complment. Altern. Med., 3(2): 267-272, (2006).
48. Ropper AH, et al. Dementia and the amnesic (Korsakoff) syndrome with comments on the neurology of intelligence and memory. In: Ropper AH, et al. (9eds.) Adams and Victor's Principles of Neurology. McGraw-Hill, New York, 2009, pp. 444-463.
49. Agarwal A, Malini S, Bairy KL, Rao MS, Effect of Tinospora cordifolia on learning and memory in normal and memory deficit rats. Ind. J. Pharmacol., 34 (5): 339-349, (2002).
50. Jana U, Chattopadhyay RN, Shw BP, Preliminary studies on anti-inflammaory activity of Zingiber officinale Rosc., Vitex negundo Linn. and Tinospora cordifolia (Willid) Miers in albino rats. Indian J. Pharm., 31 (3): 232-233, (1999).
51. Meravanige G, Priyadarshini, K. Influence of Tinospora cordifolia on wound healing in albino rats. International J Pharma Bio Sci, 3 (2): 379-384
52. Jagetia GC, Nayak V, Vidyasagar MS, Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in cultured HeLa cells. Cancer Lett., 127 (1-2): 71-82, (1998).
53. Vedavathy S, Rao KN, Antipyretic activity of six indigenous medicinal plants of Tirumala Hills, Andhra Pradesh, India. J. Ethnopharmacol., 33 (1-2): 193-196, (1991).
54. Adhvaryu, MR, Reddy N, Parabia MH, Effects of four Indian medicinal herbs on Isoniazid-Rifampicin- and Pyrazinamideinduced hepatic injury and immunosuppression in guinea pigs. World. J. Gastroenterol., 13(23): 3199-3205, (2007).
55. Mehrotra R, Katiyar CK, Gupta AP, Hepatoprotective compositions and composition for treatment of conditions related to hepatitis B and E infection. US Patent US 749296, 2000.
56. Bafna PA, Balaraman R, Anti-ulcer and anti-oxidant activity of pepticare, a herbomineral formulation. Phytomedicine, 12, (4): 264-270, (2005).
57. Bhar MK, Das SK, Chakraborty AK, Mandal TK, Roy S, Hepatoprotective effect of Enliv?® on paracetamol-induced liver injury. Indian J. Pharmacol., 37 (4): 257-258, (2005).
58. Stanely M, Prince P, Menon VP, Gunasekaran G, Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J. Ethnopharmacol., 64 (1): 53-57, (1999).
59. Prince PS, Kamalakkannan N, Menon VP, Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic wistar rats. Acta Pol. Pharm., 61(4): 283-287, (2004).
60. Prince PS, Padmanabhan M, Menon VP, Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan-induced diabetic liver and kidney. Phytotherapy Res.,, 18(9): 785-787, (2004)
61. Rawal AK, Muddeshwar MG, Bisis SK, Effect of Rubia cordifolia, Fagonia cretica linn, and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygen-glucose deprivation in rat hippocampal slices. Biochem Biophys. Res. Commun., 324(2): 588-596, (2004).
62. Rawal AK, Muddeshwar MG, Bisis SK, Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system inrat Hippocampal slices subjected to oxygen glucose deprivation. BMC Complement. Altern. Med., 4: 11, (2004)
63. Jagetia, GC, Baliga MS, The evaluation of nitric oxide scavenging activity of certain Indian medicinal plants in vitro: a preliminary study. J. Med. Food., 7(3): 343-348, (2004).
64. Bhattacharyya D, Mukherjee R, Pandit S, Das N, Sur TK, Prevention of carbon tetrachloride induced hepatotoxicity in rats by HIMOLIV, a polyherbal formulation. Indian J. Pharmacol., 47(4): 435-440, (2003).
65. Tasaduq SA, Singh K, Sethi S, Sharma SC, Bedi KL, Singh J, Jaggi BS, Johri RK, Hepatocurative and antioxidant profile of HP-1, a polyherbal Phytomedicine. Hum. Exp. Toxicol., 22(12): 639-645.
66. Prince, PS, Menon VP, Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J. Ethnopharmacol., 65(3): 277-281, (1999).
67. Stanely M, Prince P, Menon VP, Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytother. Res., 15(3): 213-218, (2001).
68. Mathew S, Kuttan G, Antioxidant activity of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity. J. Exp. Clin. Cancer Res., 16(4): 407-411, (1997).
69. Kapur P, Jarry H, Wuttke W, Pereira BMJ, Seidlova-Wuttke D, Evaluation of the antiosteoporotic potential of Tinospora cordifolia in female rats. Maturitas, 59 (4): 329-338, (2008).
70. Abiramasundari G, Sumalatha KR, Sreepriya M. Effects of Tinospora cordifolia on the proliferation, osteogenic differentiation and mineralization of osteoblast model systems in vitro. J Ethnophamacol., 141(1): 474-80, (2012)
71. Bousquet J, Bullinger M, Fayol C, Marquis P, Valentin B, Burtin B, Assessment of quality of life in patients with perennial allergic rhinitis with the French version of the SF-36 Health Status Questionnaire. J. Allergy Clin. Immunol. 94 (1: 182-188, (1994).
72. Simons FE, Rhinitis: recent advances. Pediatr Clin North Am.,35 (3): 1053-74, (1988).
73. Puranik. KN, Kammar KF, Devi S, Modulation of morphology and some gluconeogenic enzymes ac-tivity by Tinospora cordifolia (Willd.) in diabetic rat kidney. Biomed. Res., 18(3): 179-183, (2007).
74. Rajalakshmi M, Eliza J, Priya CE, Nirmala A, Daisy P, Anti-diabetic properties of Tinospora cordifolia stem extracts on streptozotocin- induced diabetic rats. Afr. J. Pharm. Pharmacol., 3(5): 171-180, (2009).
75. Grover JK, Vats V, Rathi SS, Antihyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J. Ethnopharmacol., 73(3): 461-470, (2000).
76. Stanely P, Prince M, Menon VP, Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxaninduced diabetic rats. J. Ethnopharmacol., 70(1): 9-15, (2000).
77. Wadood N, Wadood A, Shah SA, Effect of Tinospora cordifolia on blood glucose and total lipid levels of normal and alloxandiabetic rabbits. Planta Med., 58(2): 131-36, (1992).
78. Shivananjappa, MM, Muralidhara, Abrogation of maternal and fetal oxidative stress in the streptozotocin-induced diabetic rat by dietary supplements of Tinospora cordifolia. Nutrition, 28 (5): 581-587, 2011.
79. Subramanian M, Chintalwar GJ, Chattopadhyay S, Radioprotective property of polysaccharide in Tinospora cordifolia. Indian J. Biochem. Biophy., 40, 22-26, (2003.
80. Rao PR, Kumar VK, Viswanath RK, Subbaraju GV, Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats. Biol. Pharm. Bull., 28(12): 2319-2322, (2005).
81. Mary NK, Babu BH, Padikkala J, Antiatherogenic effect of Caps HT2, aherbal Ayurvedic medicine formulation. Phytomedicine, 10(6-7): 474-82, (2003).
82. Khattak SG, Gilani SN, Ikram M, Antipyretic studies on some indigenous Pakistani medicinal plants: II. J. Ethnopharmacol., 14 (1): 45-51, (1985).
83. Goel HC, Prasad J, Singh S, Sagar RK, Agrawala PK, Bala M, Sinha AK, Dogra R, Radioprotective potential of an herbal extract of Tinospora cordifolia. J. Radiat. Res., 45(1): 61-68, (2004)