Mixed chelate copper complex, Casiopeina IIgly®, binds and degrades nucleic acids: A mechanism of cytotoxicity

Chemico-Biological Interactions

Volumn 165, Issue 3, 2007, Pages 189-199

  Rivero Müller, Adolfo ^a   De Vizcaya Ruiz, Andrea ^a,b   Plant, Nick ^a   Ruiz, Lena ^c   Dobrota, Miloslav ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

8 oxodG; Casiopeinas; Copper complexes; Mixed chelate; Nucleic acid; Redox reaction; ROS

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ASCORBIC ACID; CASIOPEINA; CATALASE; COPPER COMPLEX; DNA; EDETIC ACID; GENOMIC DNA; HYDROXYL RADICAL; METAL; METAL CHELATE; NUCLEIC ACID; OXYGEN; PLASMID DNA; REACTIVE OXYGEN METABOLITE; REDUCING AGENT; RNA; SUPEROXIDE DISMUTASE; TRIENTINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHELATION; CHEMICAL BINDING; CHEMICAL REACTION; CHROMATIN; COMPLEX FORMATION; CYTOTOXICITY; DNA BINDING; DNA DEGRADATION; DNA STRAND BREAKAGE; MOLECULAR INTERACTION; NONHUMAN; OXIDATION REDUCTION REACTION; REACTION ANALYSIS; RNA DEGRADATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ASCORBIC ACID; CATALASE; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; HUMANS; NUCLEIC ACIDS; ORGANOMETALLIC COMPOUNDS; PHENANTHROLINES; SUPEROXIDE DISMUTASE;

EID: 33846889775     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2006.12.002     Document Type: Article

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