Role of T follicular helper cells and their associated molecules in the pathogenesis of chronic hepatitis B virus infection

Experimental and Therapeutic Medicine

Volumn 5, Issue 3, 2013, Pages 885-889

  Xing, Tongjing ^a   Xu, Hongtao ^a   Yu, Wenqing ^a  

^a TAIZHOU PEOPLE S HOSPITAL   (China)

Author keywords

Chronic hepatitis B; Interleukin 21; T follicular helper cells

Indexed keywords

CD19 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; HEPATITIS B (E) ANTIGEN; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; INTERLEUKIN 21; UNCLASSIFIED DRUG; VIRUS DNA;

ADULT; ARTICLE; B LYMPHOCYTE; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HELPER CELL; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION;

EID: 84873185394     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.864     Document Type: Article

References (20)

1. Hong Y, Peng Y, Mi M, Xiao H, et al: Lentivector expressing HBsAg and immunoglobulin Fc fusion antigen induces potent immune responses and results in seroconversion in HBsAg transgenic mice. Vaccine 29: 3909-3916, 2011.
2. Chisari FV: Rous-Whipple Award Lecture. Viruses, immunity and cancer: lessons from hepatitisB. Am J Pathol 156: 1117-1132, 2000.
3. Zhu J and Paul WE: Heterogeneity and plasticity of T helper cells. Cell Res 20: 4-12, 2010.
4. Durrant DM and Metzger DW: Emerging roles of T helper subsets in the pathogenesis of asthma. Immunol Invest 39: 526-549, 2010.
5. Breitfeld D, Ohl L, Kremmer E, Ellwart J, et al: Follicular Bhelper Tcells express CXC chemokine receptor 5, localize to B cell follicles and support immunoglobulin production. J Exp Med 192: 1545-1552, 2000.
6. Schaerli P, Willimann K, Lang AB, Lipp M, et al: CXC chemokine receptor 5 expression defines follicular homing Tcells with B cell helper function. J Exp Med 192: 1553-1562, 2000.
7. Crotty S: Follicular helper CD4 Tcells (TFH). Annu Rev Immunol 29: 621-663, 2011.
8. Rehermann B and Nascimbeni M: Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5: 215-229, 2005.
9. Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association: The guideline of prevention and treatment of chronic hepatitis B (2010 version). Zhonghua Gan Zang Bing Za Zhi 19: 13-24, 2011 (In Chinese).
10. Fazilleau N, Mark L, McHeyzer-Wilimas LJ and McHeyzer-Williams MG: Follicular helper cells: lineage and locations. Immunity 30: 324-335, 2009.
11. + TFH cells in patients with immune-active chronic hepatitisB. PLoS One 6: e21698, 2011.
12. Haynes NM, Allen CD, Lesley R, Ansel KM, et al: Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1 high germinal center-associated subpopulation. J Immunol 179: 5099-5108, 2007.
13. Vinuesa CG, Tangye SG, Moser B and Mackay CR: Follicular Bhelper Tcells in antibody responses and auto immunity. Nature Rev Immunol 5: 853-865, 2005.
14. Wu Y and Wen J: Role of B lymphocytes in patients with chronic hepatitisB. Clinical Focus 21: 31-33, 2006 (In Chinese).
15. Spolski R and Leonard WJ: IL-21 and T follicular helper cells. Int Immunol 22: 7-12, 2010.
16. Hu C, Chen C, Tan X and Shi T: Effects of IL-21 on B lymphocytes proliferation and HBeAb production in chronic hepatitis B patients. J Immunol 27: 126-129, 2011 (In Chinese).
17. Yi JS, Cox MA and Zajac AJ: Interleukin-21: a multifunctional regulator of immunity to infections. Microbes Infect 12: 1111-1119, 2010.
18. Publicover J, Goodsell A, Nishimura S, Vilarinho S, et al: IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitisB. J Clin Invest121: 1154-1162, 2011.
19. Yi JS, Du M and Zajac AJ: A vital role for interleukin-21 in the control of a chronic viral infection. Science 324: 1572-1576, 2009.
20. Coquet JM, Kyparissoudis K, Pellicci DG, Besra G, et al: IL-21 is produced by NKTcells and modulates NKTcell activation and cytokine production. J Immunol 178: 2827-2834, 2007.