Use and validation of HT/HC assays to support 21st century toxicity evaluations

Regulatory Toxicology and Pharmacology

Volumn 65, Issue 2, 2013, Pages 259-268

  Patlewicz, Grace ^a   Simon, Ted ^b   Goyak, Katy ^c   Phillips, Richard D ^c   Rowlands, J Craig ^d   Seidel, Shawn D ^d   Becker, Richard A ^e  

^a DUPONT COMPANY   (United States)

^b Ted Simon LLC   (United States)

^c EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

^d DOW CHEMICAL COMPANY   (United States)

^e American Chemistry Council   (United States)

Author keywords

(Q)SAR; Biomarkers; Dosimetry; High throughput high content (HT HC) assays; In vitro testing; Predictive model; Risk assessment; ToxCast; Validation

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN RECEPTOR; ATRAZINE; ESTROGEN RECEPTOR; FENARIMOL; LINURON; METHOXYCHLOR; PHTHALIC ACID DIBUTYL ESTER; VINCLOZOLIN;

ADVERSE OUTCOME; ANALYTIC METHOD; ARTICLE; BINDING ASSAY; CHEMICAL MODEL; DNA REPAIR; DNA SEQUENCE; HIGH THROUGHPUT AND HIGH CONTENT METHOD; HOMEOSTASIS; HUMAN; LIGAND BINDING; MUTAGENESIS; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RELIABILITY; SENSITIVITY AND SPECIFICITY; TOXICITY TESTING; VALIDITY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; RISK ASSESSMENT; TOXICITY TESTS; XENOBIOTICS;

EID: 84873148929     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2012.12.008     Document Type: Article

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