Glutathione reductase is inhibited by acetaminophen-glutathione conjugate in vitro

Physiological Research

Volumn 59, Issue 2, 2010, Pages 225-232

  Rousar T ^a,b   Parik P ^b   Kucera O ^a   Bartos M ^b   Cervinkova Z ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF PARDUBICE   (Czech Republic)

Author keywords

Acetaminophen toxicity; Glutathione; Glutathione reductase; Hepatotoxicity

Indexed keywords

ANALGESIC AGENT; GLUTATHIONE; GLUTATHIONE REDUCTASE; PARACETAMOL;

ANIMAL; ARTICLE; CELL CULTURE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG COMBINATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; IN VITRO STUDY; LIVER CELL; MALE; METABOLISM; PATHOLOGY; RAT; SYNTHESIS; WISTAR RAT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENZYME ACTIVATION; GLUTATHIONE; GLUTATHIONE REDUCTASE; HEPATOCYTES; MALE; RATS; RATS, WISTAR;

EID: 77953924015     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Allameh A, Alikhani N: Acetaminophen-glutathione conjugate formation in a coupled cytochrome P-450-glutathione S-transferase assay system mediated by subcellular preparations from adult and weanling rat tissues. Toxicol In Vitro 16: 637-641, 2002.
2. Armesto J, Frutos N, Gonzalez R, Pascual C: In vitro activation of hepatic glutathione reductase from mice by lobenzarit disodium. Agents Actions 39: 69-71, 1993.
3. Bajt ML, Knight TR, Lemasters JJ, Jaeschke H: Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol Sci 80: 343-349, 2004.
4. Becker K, Gui M, Schirmer RH: Inhibition of human glutathione reductase by S-nitrosoglutathione. Eur J Biochem 234: 472-478, 1995.
5. Berry M, Edwards A, Barritt G: High-yield preparation of isolated hepatocytes from rat liver. In: Isolated Hepatocytes Preparation, Properties and Application. R. Burdon, P. Van Knippenberg (eds), Elsevier, New York, 1991, pp 15-81.
6. Carlberg I, Mannervik B: Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J Biol Chem 250: 5475-5480, 1975.
7. Coles B, Wilson I, Wardman P, Hinson JA, Nelson SD, Ketterer B: The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: a stopped-flow kinetic study. Arch Biochem Biophys 264: 253-260, 1988.
8. Henderson CJ, Wolf CR: Disruption of the glutathione transferase pi class genes. Methods Enzymol 401: 116-135, 2005.
9. Henderson CJ, Wolf CR, Kitteringham N, Powell H, Otto D, Park BK: Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi. Proc Natl Acad Sci USA 97: 12741-12745, 2000.
10. Hinson JA, Pike SL, Pumford NR, Mayeux PR: Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem Res Toxicol 11: 604-607, 1998.
11. Chen C, Hennig GE, Manautou JE: Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR-) hyperbilirubinemic rats. Drug Metab Dispos 31: 798-804, 2003.
12. Jaeschke H, Bajt ML: Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 89: 31-41, 2006.
13. Jaeschke H, Knight TR, Bajt ML: The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett 144: 279-288, 2003.
14. James LP, Mayeux PR, Hinson JA: Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 31: 1499-1506, 2003.
15. Jollow DJ, Mitchell JR, Potter WZ, Davis DC, Gillette JR, Brodie BB: Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther 187: 195-202, 1973.
16. Kaplowitz N: Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology 40: 23-26, 2004
17. Knight TR, Kurtz A, Bajt ML, Hinson JA, Jaeschke H: Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress. Toxicol Sci 62: 212-220, 2001.
18. Kon K, Kim JS, Jaeschke H, Lemasters JJ: Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 40: 1170-1179, 2004.
19. Lee WM: Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. Hepatology 40: 6-9, 2004.
20. Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB: Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther 187: 185-194, 1973.
21. Ochi T: Effects of an organic hydroperoxide on the activity of antioxidant enzymes in cultured mammalian cells. Toxicology 61: 229-239, 1990.
22. Pastore A, Federici G, Bertini E, Piemonte F: Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta 333: 19-39, 2003.
23. Pumford NR, Halmes NC, Martin BM, Cook RJ, Wagner C, Hinson JA: Covalent binding of acetaminophen to N-10-formyltetrahydrofolate dehydrogenase in mice. J Pharmacol Exp Ther 280: 501-505, 1997.
24. Qiu Y, Benet LZ, Burlingame AL: Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. J Biol Chem 273: 17940-17953, 1998.
25. Roušar T, Kučera O, Křiváková P, Lotková H, Kanďár R, Mužáková V, Červinková Z: Evaluation of oxidative status in acetaminophen treated rat hepatocytes in culture. Physiol Res 58: 239-246, 2009.
26. Rzucidlo SJ, Bounous DI, Jones DP, Brackett BG: Acute acetaminophen toxicity in transgenic mice with elevated hepatic glutathione. Vet Hum Toxicol 42: 146-150, 2000.
27. Silva VM, Thibodeau MS, Chen C, Manautou JE: Transport deficient (TR-) hyperbilirubinemic rats are resistant to acetaminophen hepatotoxicity. Biochem Pharmacol 70: 1832-1839, 2005.
28. Thatcher NJ, Murray S: Analysis of the glutathione conjugate of paracetamol in human liver microsomal fraction by liquid chromatography mass spectrometry. Biomed Chromatogr 15: 374-378, 2001.
29. Vessey DA, Lee KH: Inactivation of enzymes of the glutathione antioxidant system by treatment of cultured human keratinocytes with peroxides. J Invest Dermatol 100: 829-833, 1993.