The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate

Biomaterials

Volumn 34, Issue 11, 2013, Pages 2710-2718

  O'Connor, Stephen ^a   Szwej, Emilia ^a   Nikodinovic Runic, Jasmina ^a,g   O'Connor, Aisling ^a   Byrne, Annette T ^b   Devocelle, Marc ^b   O'Donovan, Norma ^c   Gallagher, William M ^a   Babu, Ramesh ^d,e   Kenny, Shane T ^a   Zinn, Manfred ^f,h   Zulian, Qun Ren ^f   O'Connor, Kevin E ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c DUBLIN CITY UNIVERSITY   (Ireland)

^d Centre for Research on Adaptive Nanostructures and Nanodevices   (Ireland)

^e TRINITY COLLEGE DUBLIN   (Ireland)

^f SWISS FEDERAL LABORATORIES FOR MATERIALS SCIENCE AND TECHNOLOGY   (Switzerland)

^g UNIVERSITY OF BELGRADE   (Serbia)

^h UNIVERSITY OF APPLIED SCIENCES WESTERN SWITZERLAND   (Switzerland)

Author keywords

(R) 3 hydroxydecanoic acid; Antimicrobial peptides; Apoptosis; Cancer biology; Monomer; Polyhydroxyalkanoate

Indexed keywords

ANTICANCER ACTIVITIES; ANTIMICROBIAL PEPTIDE; CANCER BIOLOGY; CANCER CELLS; CIS-PLATIN; DECANOIC ACID; GEMCITABINE; HYDROXYL MOIETY; INDUCED APOPTOSIS; NANOMOLAR RANGE; POLY-HYDROXYALKANOATE; PSEUDOMONAS PUTIDA; TAXOTERE;

CELL DEATH; CHAIN LENGTH; DISEASES; DRUG PRODUCTS; MONOMERS; PLATINUM COMPOUNDS; SATURATED FATTY ACIDS;

PEPTIDES;

3 HYDROXYDECANOIC ACID; 5 HYDROXYDECANOIC ACID; ANTIMICROBIAL CATIONIC PEPTIDE; CISPLATIN; DECANOIC ACID; DOCETAXEL; GEMCITABINE; MONOMER; OMEGA HYDROXYDECANOIC ACID; POLYHYDROXYALKANOIC ACID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL LINE; CELL PROLIFERATION; DRUG CONJUGATION; DRUG POTENTIATION; HELA CELL; HUMAN; HUMAN CELL; HYDROXYLATION; IC 50; MITOCHONDRION; PRIORITY JOURNAL;

ANTICARCINOGENIC AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; APOPTOSIS; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CISPLATIN; DECANOIC ACIDS; DEOXYCYTIDINE; DRUG SYNERGISM; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MICROSCOPY, CONFOCAL; POLYHYDROXYALKANOATES; TAXOIDS;

PSEUDOMONAS PUTIDA;

EID: 84873085844     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.12.032     Document Type: Article

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