메뉴 건너뛰기




Volumn 13, Issue , 2013, Pages

Graded or threshold response of the tet-controlled gene expression: All depends on the concentration of the transactivator

Author keywords

Autoregulated; Self contained; Tet controlled gene expression; Threshold response; Transactivator concentration

Indexed keywords

AUTOREGULATED; CELL POPULATIONS; DOSE RESPONSE; DOXYCYCLINE; DYNAMIC RANGE; INDUCTION KINETICS; LUCIFERASE ACTIVITIES; PRIMARY CELLS; SELF-CONTAINED; SIMULTANEOUS INTEGRATION; THRESHOLD RESPONSE; TRANSACTIVATORS; VECTOR SYSTEMS;

EID: 84873060859     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-13-5     Document Type: Article
Times cited : (7)

References (48)
  • 1
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • 10.1073/pnas.89.12.5547, 49329, 1319065
    • Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 1992, 89(12):5547-5551. 10.1073/pnas.89.12.5547, 49329, 1319065.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.12 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 2
    • 0034608802 scopus 로고    scopus 로고
    • Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity
    • 10.1073/pnas.130192197, 16653, 10859354
    • Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard H, Hillen W. Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci USA 2000, 97(14):7963-7968. 10.1073/pnas.130192197, 16653, 10859354.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.14 , pp. 7963-7968
    • Urlinger, S.1    Baron, U.2    Thellmann, M.3    Hasan, M.T.4    Bujard, H.5    Hillen, W.6
  • 3
    • 2442475398 scopus 로고    scopus 로고
    • Viral evolution as a tool to improve the tetracycline-regulated gene expression system
    • 10.1074/jbc.M313895200, 14761948
    • Das AT, Zhou X, Vink M, Klaver B, Verhoef K, Marzio G, Berkhout B. Viral evolution as a tool to improve the tetracycline-regulated gene expression system. J Biol Chem 2004, 279(18):18776-18782. 10.1074/jbc.M313895200, 14761948.
    • (2004) J Biol Chem , vol.279 , Issue.18 , pp. 18776-18782
    • Das, A.T.1    Zhou, X.2    Vink, M.3    Klaver, B.4    Verhoef, K.5    Marzio, G.6    Berkhout, B.7
  • 4
    • 33748854037 scopus 로고    scopus 로고
    • Optimization of the Tet-On system for regulated gene expression through viral evolution
    • 10.1038/sj.gt.3302780, 16724096
    • Zhou X, Vink M, Klaver B, Berkhout B, Das AT. Optimization of the Tet-On system for regulated gene expression through viral evolution. Gene Ther 2006, 13(19):1382-1390. 10.1038/sj.gt.3302780, 16724096.
    • (2006) Gene Ther , vol.13 , Issue.19 , pp. 1382-1390
    • Zhou, X.1    Vink, M.2    Klaver, B.3    Berkhout, B.4    Das, A.T.5
  • 5
    • 0030467622 scopus 로고    scopus 로고
    • Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells
    • Yu JS, Sena-Esteves M, Paulus W, Breakefield XO, Reeves SA. Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells. Cancer Res 1996, 56(23):5423-5427.
    • (1996) Cancer Res , vol.56 , Issue.23 , pp. 5423-5427
    • Yu, J.S.1    Sena-Esteves, M.2    Paulus, W.3    Breakefield, X.O.4    Reeves, S.A.5
  • 6
    • 0029839389 scopus 로고    scopus 로고
    • Inducible gene expression by retrovirus-mediated transfer of a modified tetracycline-regulated system
    • 190626, 8709228
    • Iida A, Chen ST, Friedmann T, Yee JK. Inducible gene expression by retrovirus-mediated transfer of a modified tetracycline-regulated system. J Virol 1996, 70(9):6054-6059. 190626, 8709228.
    • (1996) J Virol , vol.70 , Issue.9 , pp. 6054-6059
    • Iida, A.1    Chen, S.T.2    Friedmann, T.3    Yee, J.K.4
  • 7
    • 0029824279 scopus 로고    scopus 로고
    • Novel retroviral vector transferring a suicide gene and a selectable marker gene with enhanced gene expression by using a tetracycline-responsive expression system
    • 190890, 8892941
    • Hwang JJ, Scuric Z, Anderson WF. Novel retroviral vector transferring a suicide gene and a selectable marker gene with enhanced gene expression by using a tetracycline-responsive expression system. J Virol 1996, 70(11):8138-8141. 190890, 8892941.
    • (1996) J Virol , vol.70 , Issue.11 , pp. 8138-8141
    • Hwang, J.J.1    Scuric, Z.2    Anderson, W.F.3
  • 8
    • 0034202721 scopus 로고    scopus 로고
    • Lentiviral vectors: regulated gene expression
    • 10.1006/mthe.2000.0083, 10933976
    • Kafri T, van Praag H, Gage FH, Verma IM. Lentiviral vectors: regulated gene expression. Mol Ther 2000, 1(6):516-521. 10.1006/mthe.2000.0083, 10933976.
    • (2000) Mol Ther , vol.1 , Issue.6 , pp. 516-521
    • Kafri, T.1    van Praag, H.2    Gage, F.H.3    Verma, I.M.4
  • 9
    • 0036193248 scopus 로고    scopus 로고
    • Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors
    • 10.1006/mthe.2002.0542, 11863414
    • Vigna E, Cavalieri S, Ailles L, Geuna M, Loew R, Bujard H, Naldini L. Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors. Mol Ther 2002, 5(3):252-261. 10.1006/mthe.2002.0542, 11863414.
    • (2002) Mol Ther , vol.5 , Issue.3 , pp. 252-261
    • Vigna, E.1    Cavalieri, S.2    Ailles, L.3    Geuna, M.4    Loew, R.5    Bujard, H.6    Naldini, L.7
  • 10
    • 28644442724 scopus 로고    scopus 로고
    • Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter
    • 10.1093/nar/gni062, 1074399, 15809225
    • Markusic D, Oude-Elferink R, Das AT, Berkhout B, Seppen J. Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter. Nucleic Acids Res 2005, 33(6):e63. 10.1093/nar/gni062, 1074399, 15809225.
    • (2005) Nucleic Acids Res , vol.33 , Issue.6
    • Markusic, D.1    Oude-Elferink, R.2    Das, A.T.3    Berkhout, B.4    Seppen, J.5
  • 11
    • 38049000861 scopus 로고    scopus 로고
    • Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons
    • 10.1016/j.jneumeth.2007.09.023, 17983662
    • Gascon S, Paez-Gomez JA, Diaz-Guerra M, Scheiffele P, Scholl FG. Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons. J Neurosci Methods 2008, 168(1):104-112. 10.1016/j.jneumeth.2007.09.023, 17983662.
    • (2008) J Neurosci Methods , vol.168 , Issue.1 , pp. 104-112
    • Gascon, S.1    Paez-Gomez, J.A.2    Diaz-Guerra, M.3    Scheiffele, P.4    Scholl, F.G.5
  • 12
    • 44449094037 scopus 로고    scopus 로고
    • Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brain
    • 10.1002/jgm.1178, 2962808, 18324737
    • Liu B, Wang S, Brenner M, Paton JF, Kasparov S. Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brain. J Gene Med 2008, 10(5):583-592. 10.1002/jgm.1178, 2962808, 18324737.
    • (2008) J Gene Med , vol.10 , Issue.5 , pp. 583-592
    • Liu, B.1    Wang, S.2    Brenner, M.3    Paton, J.F.4    Kasparov, S.5
  • 13
    • 58849090016 scopus 로고    scopus 로고
    • An improved tet-on system for gene expression in neurons delivered by a single lentiviral vector
    • 10.1089/hum.2008.018, 20377365
    • Tian X, Wang G, Xu Y, Wang P, Chen S, Yang H, Gao F, Xu A, Cao F, Jin X, et al. An improved tet-on system for gene expression in neurons delivered by a single lentiviral vector. Hum Gene Ther 2009, 20(2):113-123. 10.1089/hum.2008.018, 20377365.
    • (2009) Hum Gene Ther , vol.20 , Issue.2 , pp. 113-123
    • Tian, X.1    Wang, G.2    Xu, Y.3    Wang, P.4    Chen, S.5    Yang, H.6    Gao, F.7    Xu, A.8    Cao, F.9    Jin, X.10
  • 14
    • 80155145283 scopus 로고    scopus 로고
    • Polyswitch lentivectors: "all-in-one" lentiviral vectors for drug-inducible gene expression, live selection, and recombination cloning
    • 10.1089/hum.2010.179, 21761975
    • Giry-Laterriere M, Cherpin O, Kim YS, Jensen J, Salmon P. Polyswitch lentivectors: "all-in-one" lentiviral vectors for drug-inducible gene expression, live selection, and recombination cloning. Hum Gene Ther 2011, 22(10):1255-1267. 10.1089/hum.2010.179, 21761975.
    • (2011) Hum Gene Ther , vol.22 , Issue.10 , pp. 1255-1267
    • Giry-Laterriere, M.1    Cherpin, O.2    Kim, Y.S.3    Jensen, J.4    Salmon, P.5
  • 15
    • 17644388429 scopus 로고    scopus 로고
    • Efficient Tet-dependent expression of human factor IX in vivo by a new self-regulating lentiviral vector
    • 10.1016/j.ymthe.2004.11.017, 15851015
    • Vigna E, Amendola M, Benedicenti F, Simmons AD, Follenzi A, Naldini L. Efficient Tet-dependent expression of human factor IX in vivo by a new self-regulating lentiviral vector. Mol Ther 2005, 11(5):763-775. 10.1016/j.ymthe.2004.11.017, 15851015.
    • (2005) Mol Ther , vol.11 , Issue.5 , pp. 763-775
    • Vigna, E.1    Amendola, M.2    Benedicenti, F.3    Simmons, A.D.4    Follenzi, A.5    Naldini, L.6
  • 16
    • 0030001394 scopus 로고    scopus 로고
    • Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette
    • 10.1073/pnas.93.11.5185, 39219, 8643550
    • Hofmann A, Nolan GP, Blau HM. Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette. Proc Natl Acad Sci USA 1996, 93(11):5185-5190. 10.1073/pnas.93.11.5185, 39219, 8643550.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.11 , pp. 5185-5190
    • Hofmann, A.1    Nolan, G.P.2    Blau, H.M.3
  • 17
    • 0029656105 scopus 로고    scopus 로고
    • Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells
    • 189788, 8523582
    • Paulus W, Baur I, Boyce FM, Breakefield XO, Reeves SA. Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells. J Virol 1996, 70(1):62-67. 189788, 8523582.
    • (1996) J Virol , vol.70 , Issue.1 , pp. 62-67
    • Paulus, W.1    Baur, I.2    Boyce, F.M.3    Breakefield, X.O.4    Reeves, S.A.5
  • 18
    • 0030868549 scopus 로고    scopus 로고
    • Versatile retrovirus vector systems for regulated gene expression in vitro and in vivo
    • 2230217, 9260158
    • Lindemann D, Patriquin E, Feng S, Mulligan RC. Versatile retrovirus vector systems for regulated gene expression in vitro and in vivo. Mol Med 1997, 3(7):466-476. 2230217, 9260158.
    • (1997) Mol Med , vol.3 , Issue.7 , pp. 466-476
    • Lindemann, D.1    Patriquin, E.2    Feng, S.3    Mulligan, R.C.4
  • 19
    • 0035190644 scopus 로고    scopus 로고
    • Retroviral vectors for the transduction of autoregulated, bidirectional expression cassettes
    • 10.1006/mthe.2001.0480, 11708885
    • Unsinger J, Kroger A, Hauser H, Wirth D. Retroviral vectors for the transduction of autoregulated, bidirectional expression cassettes. Mol Ther 2001, 4(5):484-489. 10.1006/mthe.2001.0480, 11708885.
    • (2001) Mol Ther , vol.4 , Issue.5 , pp. 484-489
    • Unsinger, J.1    Kroger, A.2    Hauser, H.3    Wirth, D.4
  • 20
    • 74349110497 scopus 로고    scopus 로고
    • Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo
    • 10.1038/gt.2009.109, 19727135
    • Centlivre M, Zhou X, Pouw SM, Weijer K, Kleibeuker W, Das AT, Blom B, Seppen J, Berkhout B, Legrand N. Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo. Gene Ther 2010, 17(1):14-25. 10.1038/gt.2009.109, 19727135.
    • (2010) Gene Ther , vol.17 , Issue.1 , pp. 14-25
    • Centlivre, M.1    Zhou, X.2    Pouw, S.M.3    Weijer, K.4    Kleibeuker, W.5    Das, A.T.6    Blom, B.7    Seppen, J.8    Berkhout, B.9    Legrand, N.10
  • 21
    • 33845733725 scopus 로고    scopus 로고
    • Promoter crosstalk effects on gene expression
    • 10.1016/j.jmb.2006.10.009, 17097679
    • Hampf M, Gossen M. Promoter crosstalk effects on gene expression. J Mol Biol 2007, 365(4):911-920. 10.1016/j.jmb.2006.10.009, 17097679.
    • (2007) J Mol Biol , vol.365 , Issue.4 , pp. 911-920
    • Hampf, M.1    Gossen, M.2
  • 22
    • 0023805741 scopus 로고
    • Negative effect of the transcriptional activator GAL4
    • 10.1038/334721a0, 3412449
    • Gill G, Ptashne M. Negative effect of the transcriptional activator GAL4. Nature 1988, 334(6184):721-724. 10.1038/334721a0, 3412449.
    • (1988) Nature , vol.334 , Issue.6184 , pp. 721-724
    • Gill, G.1    Ptashne, M.2
  • 23
    • 0025332921 scopus 로고
    • Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors
    • 10.1016/0092-8674(90)90684-7, 2163758
    • Berger SL, Cress WD, Cress A, Triezenberg SJ, Guarente L. Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors. Cell 1990, 61(7):1199-1208. 10.1016/0092-8674(90)90684-7, 2163758.
    • (1990) Cell , vol.61 , Issue.7 , pp. 1199-1208
    • Berger, S.L.1    Cress, W.D.2    Cress, A.3    Triezenberg, S.J.4    Guarente, L.5
  • 24
    • 0036827724 scopus 로고    scopus 로고
    • Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus
    • 10.1128/JVI.76.22.11605-11611.2002, 136781, 12388721
    • Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marme F, Cherel Y, Salvetti A, Hurtrel B, et al. Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus. J Virol 2002, 76(22):11605-11611. 10.1128/JVI.76.22.11605-11611.2002, 136781, 12388721.
    • (2002) J Virol , vol.76 , Issue.22 , pp. 11605-11611
    • Favre, D.1    Blouin, V.2    Provost, N.3    Spisek, R.4    Porrot, F.5    Bohl, D.6    Marme, F.7    Cherel, Y.8    Salvetti, A.9    Hurtrel, B.10
  • 25
    • 35348997553 scopus 로고    scopus 로고
    • Immune responses to gene product of inducible promoters
    • 10.2174/156652307782151461, 17979680
    • Le Guiner C, Stieger K, Snyder RO, Rolling F, Moullier P. Immune responses to gene product of inducible promoters. Curr Gene Ther 2007, 7(5):334-346. 10.2174/156652307782151461, 17979680.
    • (2007) Curr Gene Ther , vol.7 , Issue.5 , pp. 334-346
    • Le Guiner, C.1    Stieger, K.2    Snyder, R.O.3    Rolling, F.4    Moullier, P.5
  • 26
    • 77952425513 scopus 로고    scopus 로고
    • Lack of humoral immune response to the tetracycline (Tet) activator in rats injected intracranially with Tet-off rAAV vectors
    • 10.1038/gt.2010.6, 2869394, 20164859
    • Han Y, Chang QA, Virag T, West NC, George D, Castro MG, Bohn MC. Lack of humoral immune response to the tetracycline (Tet) activator in rats injected intracranially with Tet-off rAAV vectors. Gene Ther 2010, 17(5):616-625. 10.1038/gt.2010.6, 2869394, 20164859.
    • (2010) Gene Ther , vol.17 , Issue.5 , pp. 616-625
    • Han, Y.1    Chang, Q.A.2    Virag, T.3    West, N.C.4    George, D.5    Castro, M.G.6    Bohn, M.C.7
  • 27
    • 79951834881 scopus 로고    scopus 로고
    • Retroviral and transposon-based tet-regulated all-in-one vectors with reduced background expression and improved dynamic range
    • Heinz N, Schambach A, Galla M, Maetzig T, Baum C, Loew R, Schiedlmeier B. Retroviral and transposon-based tet-regulated all-in-one vectors with reduced background expression and improved dynamic range. Hum Gene Ther 2010, 22(2):166-176.
    • (2010) Hum Gene Ther , vol.22 , Issue.2 , pp. 166-176
    • Heinz, N.1    Schambach, A.2    Galla, M.3    Maetzig, T.4    Baum, C.5    Loew, R.6    Schiedlmeier, B.7
  • 28
    • 1142285223 scopus 로고    scopus 로고
    • A single lentivirus vector mediates doxycycline-regulated expression of transgenes in the brain
    • 10.1089/104303404772679968, 14975188
    • Vogel R, Amar L, Thi AD, Saillour P, Mallet J. A single lentivirus vector mediates doxycycline-regulated expression of transgenes in the brain. Hum Gene Ther 2004, 15(2):157-165. 10.1089/104303404772679968, 14975188.
    • (2004) Hum Gene Ther , vol.15 , Issue.2 , pp. 157-165
    • Vogel, R.1    Amar, L.2    Thi, A.D.3    Saillour, P.4    Mallet, J.5
  • 29
    • 30344473326 scopus 로고    scopus 로고
    • Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector
    • 10.1016/j.ymthe.2005.09.012, 16275162
    • Barde I, Zanta-Boussif MA, Paisant S, Leboeuf M, Rameau P, Delenda C, Danos O. Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector. Mol Ther 2006, 13(2):382-390. 10.1016/j.ymthe.2005.09.012, 16275162.
    • (2006) Mol Ther , vol.13 , Issue.2 , pp. 382-390
    • Barde, I.1    Zanta-Boussif, M.A.2    Paisant, S.3    Leboeuf, M.4    Rameau, P.5    Delenda, C.6    Danos, O.7
  • 30
    • 65549143271 scopus 로고    scopus 로고
    • Retroviral vectors containing Tet-controlled bidirectional transcription units for simultaneous regulation of two gene activities
    • 2702057, 19565004
    • Loew R, Vigna E, Lindemann D, Naldini L, Bujard H. Retroviral vectors containing Tet-controlled bidirectional transcription units for simultaneous regulation of two gene activities. J Mol Genet Med 2006, 2(1):107-118. 2702057, 19565004.
    • (2006) J Mol Genet Med , vol.2 , Issue.1 , pp. 107-118
    • Loew, R.1    Vigna, E.2    Lindemann, D.3    Naldini, L.4    Bujard, H.5
  • 31
    • 78549241297 scopus 로고    scopus 로고
    • Improved Tet-responsive promoters with minimized background expression
    • 10.1186/1472-6750-10-81, 3002914, 21106052
    • Loew R, Heinz N, Hampf M, Bujard H, Gossen M. Improved Tet-responsive promoters with minimized background expression. BMC Biotechnol 2010, 10:81. 10.1186/1472-6750-10-81, 3002914, 21106052.
    • (2010) BMC Biotechnol , vol.10 , pp. 81
    • Loew, R.1    Heinz, N.2    Hampf, M.3    Bujard, H.4    Gossen, M.5
  • 32
    • 76749155354 scopus 로고    scopus 로고
    • A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating gamma-retroviral vectors using targeted integration
    • 10.1038/gt.2009.134, 19865181
    • Loew R, Meyer Y, Kuehlcke K, Gama-Norton L, Wirth D, Hauser H, Stein S, Grez M, Thornhill S, Thrasher A, et al. A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating gamma-retroviral vectors using targeted integration. Gene Ther 2010, 17(2):272-280. 10.1038/gt.2009.134, 19865181.
    • (2010) Gene Ther , vol.17 , Issue.2 , pp. 272-280
    • Loew, R.1    Meyer, Y.2    Kuehlcke, K.3    Gama-Norton, L.4    Wirth, D.5    Hauser, H.6    Stein, S.7    Grez, M.8    Thornhill, S.9    Thrasher, A.10
  • 33
    • 34249298695 scopus 로고    scopus 로고
    • Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors
    • Schambach A, Galla M, Maetzig T, Loew R, Baum C. Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors. Mol Ther 2007, 15(6):1167-1173.
    • (2007) Mol Ther , vol.15 , Issue.6 , pp. 1167-1173
    • Schambach, A.1    Galla, M.2    Maetzig, T.3    Loew, R.4    Baum, C.5
  • 34
    • 0024526516 scopus 로고
    • How gene activators work
    • 10.1038/scientificamerican0189-40, 2521264
    • Ptashne M. How gene activators work. Sci Am 1989, 260(1):40-47. 10.1038/scientificamerican0189-40, 2521264.
    • (1989) Sci Am , vol.260 , Issue.1 , pp. 40-47
    • Ptashne, M.1
  • 35
    • 0027948984 scopus 로고
    • Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors
    • 395419, 7957049
    • Marcus GA, Silverman N, Berger SL, Horiuchi J, Guarente L. Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. EMBO J 1994, 13(20):4807-4815. 395419, 7957049.
    • (1994) EMBO J , vol.13 , Issue.20 , pp. 4807-4815
    • Marcus, G.A.1    Silverman, N.2    Berger, S.L.3    Horiuchi, J.4    Guarente, L.5
  • 36
    • 0029075822 scopus 로고
    • Co-regulation of two gene activities by tetracycline via a bidirectional promoter
    • 10.1093/nar/23.17.3605, 307245, 7567477
    • Baron U, Freundlieb S, Gossen M, Bujard H. Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res 1995, 23(17):3605-3606. 10.1093/nar/23.17.3605, 307245, 7567477.
    • (1995) Nucleic Acids Res , vol.23 , Issue.17 , pp. 3605-3606
    • Baron, U.1    Freundlieb, S.2    Gossen, M.3    Bujard, H.4
  • 37
    • 0032506123 scopus 로고    scopus 로고
    • Graded transcriptional response to different concentrations of a single transactivator
    • 10.1073/pnas.95.23.13670, 24877, 9811858
    • Kringstein AM, Rossi FM, Hofmann A, Blau HM. Graded transcriptional response to different concentrations of a single transactivator. Proc Natl Acad Sci USA 1998, 95(23):13670-13675. 10.1073/pnas.95.23.13670, 24877, 9811858.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.23 , pp. 13670-13675
    • Kringstein, A.M.1    Rossi, F.M.2    Hofmann, A.3    Blau, H.M.4
  • 39
    • 0028918657 scopus 로고
    • A transient three-plasmid expression system for the production of high titer retroviral vectors
    • 10.1093/nar/23.4.628, 306730, 7899083
    • Soneoka Y, Cannon PM, Ramsdale EE, Griffiths JC, Romano G, Kingsman SM, Kingsman AJ. A transient three-plasmid expression system for the production of high titer retroviral vectors. Nucleic Acids Res 1995, 23(4):628-633. 10.1093/nar/23.4.628, 306730, 7899083.
    • (1995) Nucleic Acids Res , vol.23 , Issue.4 , pp. 628-633
    • Soneoka, Y.1    Cannon, P.M.2    Ramsdale, E.E.3    Griffiths, J.C.4    Romano, G.5    Kingsman, S.M.6    Kingsman, A.J.7
  • 40
    • 0032976195 scopus 로고    scopus 로고
    • Foamy virus capsids require the cognate envelope protein for particle export
    • 104016, 10074106
    • Pietschmann T, Heinkelein M, Heldmann M, Zentgraf H, Rethwilm A, Lindemann D. Foamy virus capsids require the cognate envelope protein for particle export. J Virol 1999, 73(4):2613-2621. 104016, 10074106.
    • (1999) J Virol , vol.73 , Issue.4 , pp. 2613-2621
    • Pietschmann, T.1    Heinkelein, M.2    Heldmann, M.3    Zentgraf, H.4    Rethwilm, A.5    Lindemann, D.6
  • 41
    • 0028346738 scopus 로고
    • Photinus pyralis luciferase: vectors that contain a modified luc coding sequence allowing convenient transfer into other systems
    • 10.1016/0378-1119(94)90130-9, 8163178
    • Bonin AL, Gossen M, Bujard H. Photinus pyralis luciferase: vectors that contain a modified luc coding sequence allowing convenient transfer into other systems. Gene 1994, 141(1):75-77. 10.1016/0378-1119(94)90130-9, 8163178.
    • (1994) Gene , vol.141 , Issue.1 , pp. 75-77
    • Bonin, A.L.1    Gossen, M.2    Bujard, H.3
  • 42
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • 10.1016/0003-2697(76)90527-3, 942051
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254. 10.1016/0003-2697(76)90527-3, 942051.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 43
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987, 162(1):156-159.
    • (1987) Anal Biochem , vol.162 , Issue.1 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 44
    • 0028248861 scopus 로고
    • Sensitive, nonradioactive northern blots using alkaline transfer of total RNA and PCR-amplified biotinylated probes
    • 1030
    • Loew R, Rausch T. Sensitive, nonradioactive northern blots using alkaline transfer of total RNA and PCR-amplified biotinylated probes. Biotechniques 1994, 17(6):1026-1028. 1030.
    • (1994) Biotechniques , vol.17 , Issue.6 , pp. 1026-1028
    • Loew, R.1    Rausch, T.2
  • 45
    • 0032978712 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
    • 104046, 10074136
    • Zufferey R, Donello JE, Trono D, Hope TJ. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol 1999, 73(4):2886-2892. 104046, 10074136.
    • (1999) J Virol , vol.73 , Issue.4 , pp. 2886-2892
    • Zufferey, R.1    Donello, J.E.2    Trono, D.3    Hope, T.J.4
  • 46
    • 0031240076 scopus 로고    scopus 로고
    • The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export
    • 10.1016/S0960-9822(06)00288-0, 9285715
    • Saavedra C, Felber B, Izaurralde E. The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export. Curr Biol 1997, 7(9):619-628. 10.1016/S0960-9822(06)00288-0, 9285715.
    • (1997) Curr Biol , vol.7 , Issue.9 , pp. 619-628
    • Saavedra, C.1    Felber, B.2    Izaurralde, E.3
  • 48
    • 0026645025 scopus 로고
    • Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains
    • 10.1016/0092-8674(92)90100-Q, 1638630
    • Berger SL, Pina B, Silverman N, Marcus GA, Agapite J, Regier JL, Triezenberg SJ, Guarente L. Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains. Cell 1992, 70:251-265. 10.1016/0092-8674(92)90100-Q, 1638630.
    • (1992) Cell , vol.70 , pp. 251-265
    • Berger, S.L.1    Pina, B.2    Silverman, N.3    Marcus, G.A.4    Agapite, J.5    Regier, J.L.6    Triezenberg, S.J.7    Guarente, L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.