Estradiol-17β and its cytochrome p450- and catechol-o- methyltransferase-derived metabolites selectively stimulate production of prostacyclin in uterine artery endothelial cells: Role of estrogen receptor-α versus estrogen receptor-β

Hypertension

Volumn 61, Issue 2, 2013, Pages 509-518

  Jobe, Sheikh O ^a   Ramadoss, Jayanth ^d   Wargin, Andrew J ^a   Magness, Ronald R ^a,b,c  

^a MERITER HOSPITAL   (United States)

^b Department of Pediatrics ^*  (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

Author keywords

catecholamines; endothelium; estradiol metabolites; estrogen receptors; pregnancy; prostacyclin; thromboxane

Indexed keywords

2 HYDROXYESTRADIOL; 2 METHOXYESTRADIOL; 4 HYDROXYESTRADIOL; 4 METHOXYESTRADIOL; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CATECHOL METHYLTRANSFERASE; CYCLOOXYGENASE 1; CYTOCHROME P450; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; IONOPHORE; PHOSPHOLIPASE A2; PROSTACYCLIN; PROSTACYCLIN SYNTHASE; THROMBOXANE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENSITOMETRY; ENDOTHELIUM CELL; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; UTERINE ARTERY; UTERINE ARTERY ENDOTHELIAL CELL; UTERUS BLOOD FLOW;

ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; FEMALE; PREGNANCY; SHEEP; UTERINE ARTERY;

EID: 84873058344     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.200717     Document Type: Article

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