Effect of tumor suppressor PTEN gene on apoptosis and cell cycle of human airway smooth muscle cells

Molecular and Cellular Biochemistry

Volumn 375, Issue 1-2, 2013, Pages 1-9

  Luo, Liang ^a   Gong, Yuan Qi ^b   Qi, Xiefei ^b   Lai, Wenyan ^c   Lan, Haibing ^b   Luo, Yaling ^c  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Airway smooth muscle cells; Cell apoptosis; Cell cycle; PTEN gene

Indexed keywords

CASPASE 3; CASPASE 9; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P21;

ADENOVIRUS; AIRWAY; AIRWAY SMOOTH MUSCLE CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL LEVEL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; SMOOTH MUSCLE FIBER; TUMOR SUPPRESSOR GENE; UPREGULATION; VIRUS RECOMBINANT; WESTERN BLOTTING;

ADENOVIRIDAE; AIRWAY REMODELING; APOPTOSIS; ASTHMA; CASPASE 3; CASPASE 9; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CELLS, CULTURED; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; HUMANS; LUNG; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; TRANSFECTION;

ADENOVIRIDAE;

EID: 84873057934     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1484-7     Document Type: Article

References (27)

1. Masoli M, Fabian D, Holt S, Beasley R (2004) The global burden of asthma: executive summary of the GINA dissemination committee report. Allergy 59:469-478
2. Barnett SB, Nurmagambetov TA (2011) Costs of asthma in the United States: 2002-2007. J Allergy Clin Immunol 127:145-152
3. Zhong NS, Xu J, Shi HZ (2006) Bronchial asthma - basic and clinical study. The first edition. People's Health Publishing House, Beijing, p 14-18
4. Tliba O, Amrani Y, Panettieri RA Jr (2008) Is airway smooth muscle the "missing link" modulating airway inflammation in asthma? Chest 133:236-242
5. Bergeron C, Al-Ramli W, Hamid Q (2009) Remodeling in asthma. Proc Am Thorac Soc 6:301-305
6. Paré PD, Roberts CR, Bai TR, Wiggs BJ (1997) The functional consequences of airway remodeling in asthma. Monaldi Arch Chest Dis 52:589-596
7. Oikonomidi S, Kostikas K, Tsilioni I, Tanou K, Gourgoulianis KI, Kiropoulos TS (2009) Matrix metalloproteinases in respiratory diseases: from pathogenesis to potential clinical implications. Curr Med Chem 16:1214-1228
8. Baroffio M, Crimi E, Brusasco V (2008) Airway smooth muscle as a model for new investigative drugs in asthma. Ther Adv Respir Dis 2:129-139
9. Solway J, Irvin CG (2007) Airway smooth muscle as a target for asthma therapy. N Engl J Med 356:1367-1369
10. Janssen LJ, Killian K (2006) Airway smooth muscle as a target of asthma therapy: history and new directions. Respir Res 7:123
11. Chu EC, Tarnawski AS (2004) PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit 10:235-241
12. Wu RC, Li X, Schönthal AH (2000) Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor. Mol Cell Biochem 203:59-71
13. Day RM, Lee YH, Park AM, Suzuki YJ (2006) Retinoic acid inhibits airway smooth muscle cell migration. Am J Respir Cell Mol Biol 34:695-703
14. Stewart AL, Mhashilkar AM, Yang XH, Ekmekcioglu S, Saito Y, Sieger K, Schrock R, Onishi E, Swanson X, Mumm JB, Zumstein L, Watson GJ, Snary D, Roth JA, Grimm EA, Ramesh R, Chada S (2002) PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells. Mol Med 8:451-461
15. Hlobilková A, Knillová J, Bártek J, Lukás J, Kolár Z (2003) The mechanism of action of the tumor suppressor gene PTEN. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25
16. Dasari VR, Kaur K, Velpula KK, Gujrati M, Fassett D, Klopfenstein JD, Dinh DH, Rao JS (2010) Up-regulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway. PLoS ONE 5:e10350
17. Gu J, Tamura M, PanKov R, Danen EH, Takino T, Matsumoto K, Yamada KM (1999) Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol 146:389-403
18. Rönnstrand L, Heldin CH (2001) Mechanisms of platelet-derived growth factor-induced chemotaxis. Int J Cancer 91:757-762
19. Saito Y, Swanson X, Mhashilkar AM, Oida Y, Schrock R, Branch CD, Chada S, Zumstein L, Ramesh R (2003) Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vitro. Gene Ther 10:1961-1969
20. Huang J, Kontos CD (2002) PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. J Biol Chem 277:10760-10766
21. Yamada KM, Araki M (2001) Tumor suppressor PTEN modulator of cell signaling, growth, migration, and apoptosis. J Cell Sci 114:2375-2382
22. Huang J, Kontos CD (2002) Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN. Arterioscler Thromb Vasc Biol 22:745-751
23. Li J, Simpson L, Takahashi M, Miliaresis C, Myers MP, Tonks N, Parsons R (1998) The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res 58:5667-5672
24. Furnari FB, Huang HJ, Cavenee WK (1998) The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res 58:5002-5008
25. Moon SK, Kim HM, Kim CH (2004) PTEN induces G1 cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-κB and AP-1 in vascular smooth muscle cells. Arch Biochem Biophys 421:267-276
26. Lu Y, Lin YZ, LaPushin R, Cuevas B, Fang X, Yu SX, Davies MA, Khan H, Furui T, Mao M, Zinner R, Hung MC, Steck P, Siminovitch K, Mills GB (1999) The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer. Oncogene 18:7034-7045
27. Weng L, Brown J, Eng C (2001) PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways. Hum Mol Genet 10:237-242