Thymoquinone accelerates osteoblast differentiation and activates bone morphogenetic protein-2 and ERK pathway

International Immunopharmacology

Volumn 15, Issue 2, 2013, Pages 381-386

  Wirries, André ^a   Schubert, Ann Kristin ^a   Zimmermann, René ^a   Jabari, Samir ^b   Ruchholtz, Steffen ^a   El Najjar, Nahed ^a  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Bone morphogenetic proteins; ERK; Osteoporosis; Thymoquinone

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCALCIN; OSTEOPONTIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; THYMOQUINONE; TRANSCRIPTION FACTOR RUNX2;

ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN 3T3; DRUG EFFECT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; MINERALIZATION; OSTEOBLAST; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BENZOQUINONES; BONE MORPHOGENETIC PROTEIN 2; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; MICE; NIGELLA SATIVA; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; OSTEOPONTIN;

EID: 84873045136     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.12.033     Document Type: Article

References (28)

1. R. Baron, and E. Hesse Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives J Clin Endocrinol Metab 97 2012 311 325
2. L. Shen, X. Xie, Y. Su, C. Luo, C. Zhang, and B. Zeng Parathyroid hormone versus bisphosphonate treatment on bone mineral density in osteoporosis therapy: a meta-analysis of randomized controlled trials PLoS One 6 2011 e26267
3. J.E. Mulder, N.S. Kolatkar, and M.S. LeBoff Drug insight: existing and emerging therapies for osteoporosis Nat Clin Pract Endocrinol Metab 2 2006 670 680
4. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis Am J Med 94 1993 646 650
5. C. Cooper, G. Campion, and L.J. Melton III Hip fractures in the elderly: a world-wide projection Osteoporos Int 2 1992 285 289
6. K.B. Harris, K.L. Nealy, D.J. Jackson, and P.L. Thornton The clinical use of denosumab for the management of low bone mineral density in postmenopausal women J Pharm Pract 25 2012 310 318
7. E. Gendaszewska-Darmach, E. Laska, P. Rytczak, and A. Okruszek The chemical synthesis of metabolically stabilized 2-OMe-LPA analogues and preliminary studies of their inhibitory activity toward autotaxin Bioorg Med Chem Lett 22 2012 2698 2700
8. M.E. Wiktorowicz, R. Goeree, A. Papaioannou, J.D. Adachi, and E. Papadimitropoulos Economic implications of hip fracture: health service use, institutional care and cost in Canada Osteoporos Int 12 2001 271 278
9. R.B. Hopkins, R. Goeree, E. Pullenayegum, J.D. Adachi, A. Papaioannou, and F. Xie The relative efficacy of nine osteoporosis medications for reducing the rate of fractures in post-menopausal women BMC Musculoskelet Disord 12 2011 209
10. N. Harvey, E. Dennison, and C. Cooper Osteoporosis: impact on health and economics Nat Rev Rheumatol 6 2010 99 105
11. Nahed El-Najjar, Hala Gali-Muhtasib, Raimo A. Ketola, Pia Vuorela, Arto Urtti, and Heikki Vuorela The chemical and biological activities of quinones: overview and implications in analytical detection Phytochem Rev 10 September 2011 353 370
12. N. Sogabe, R. Maruyama, O. Baba, T. Hosoi, and M. Goseki-Sone Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats Bone 48 2011 1036 1042
13. L. Bao, L. Qin, L. Liu, Y. Wu, T. Han, and L. Xue Anthraquinone compounds from Morinda officinalis inhibit osteoclastic bone resorption in vitro Chem Biol Interact 194 2011 97 105
14. S.U. Lee, H.K. Shin, Y.K. Min, and S.H. Kim Emodin accelerates osteoblast differentiation through phosphatidylinositol 3-kinase activation and bone morphogenetic protein-2 gene expression Int Immunopharmacol 8 2008 741 747
15. M.X. Xiang, Z. Xu, H.W. Su, J. Hu, and Y.J. Yan Emodin-8-O-beta-d- glucoside from Polygonum amplexicaule D. Don var. sinense Forb. promotes proliferation and differentiation of osteoblastic MC3T3-E1 cells Molecules 16 2011 728 737
16. F. Vaillancourt, P. Silva, Q. Shi, H. Fahmi, J.C. Fernandes, and M. Benderdour Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis J Cell Biochem 112 2011 107 117
17. W.P. Chen, J.L. Tang, J.P. Bao, and L.D. Wu Thymoquinone inhibits matrix metalloproteinase expression in rabbit chondrocytes and cartilage in experimental osteoarthritis Exp Biol Med (Maywood) 235 2010 1425 1431
18. S. Umar, J. Zargan, K. Umar, S. Ahmad, C.K. Katiyar, and H.A. Khan Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats Chem Biol Interact 197 2012 40 46
19. M.I. Kara, K. Erciyas, A.B. Altan, M. Ozkut, S. Ay, and S. Inan Thymoquinone accelerates new bone formation in the rapid maxillary expansion procedure Arch Oral Biol 57 2012 357 363
20. J.L. Su, J. Chiou, C.H. Tang, M. Zhao, C.H. Tsai, and P.S. Chen CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway J Biol Chem 285 2010 31325 31336
21. J.H. Jun, W.J. Yoon, S.B. Seo, K.M. Woo, G.S. Kim, and H.M. Ryoo BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity J Biol Chem 285 2010 36410 36419
22. J.W. Lowery, D. Pazin, G. Intini, S. Kokabu, V. Chappuis, and L.P. Capelo The role of BMP2 signaling in the skeleton Crit Rev Eukaryot Gene Expr 21 2011 177 185
23. B. Sung, S. Prasad, V.R. Yadav, and B.B. Aggarwal Cancer cell signaling pathways targeted by spice-derived nutraceuticals Nutr Cancer 64 2012 173 197
24. M.S. Butt, and M.T. Sultan Nigella sativa: reduces the risk of various maladies Crit Rev Food Sci Nutr 50 2010 654 665
25. W.F. Chiou, C.H. Lee, J.F. Liao, and C.C. Chen 8-Prenylkaempferol accelerates osteoblast maturation through bone morphogenetic protein-2/p38 pathway to activate Runx2 transcription Life Sci 88 2011 335 342
26. B.H. Ali, and G. Blunden Pharmacological and toxicological properties of Nigella sativa Phytother Res 17 2003 299 305
27. N. Ghosh-Choudhury, C.C. Mandal, and G.G. Choudhury Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation J Biol Chem 282 7 2007 4983 4993
28. S.U. Lee, Y.H. Choi, Y.S. Kim, S.J. Park, H.B. Kwak, and Y.K. Min Physcion-8-O-beta-d-glucopyranoside enhances the commitment of mouse mesenchymal progenitors into osteoblasts and their differentiation: possible involvement of signaling pathways to activate BMP gene expression J Cell Biochem 109 6 2010 1148 1157