Optimized dosing of a CCR2 antagonist for amplification of vaccine immunity

International Immunopharmacology

Volumn 15, Issue 2, 2013, Pages 357-363

  Mitchell, Leah A ^a   Hansen, Ryan J ^a   Beaupre, Adam J ^a   Gustafson, Daniel L ^a   Dow, Steven W ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Antibody; Chemokine; Immune; Immunization; MCP 1; Monocytes

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; INFLUENZA VACCINE; RS 102895; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG POTENTIATION; LYMPH NODE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BENZOXAZINES; CELL MOVEMENT; DRUG DOSAGE CALCULATIONS; HALF-LIFE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; IMMUNITY, CELLULAR; INFLUENZA VACCINES; INFLUENZA, HUMAN; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, KNOCKOUT; MODELS, ANIMAL; MONOCYTES; PIPERIDINES; RECEPTORS, CCR2;

EID: 84873039083     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.11.016     Document Type: Article

References (26)

1. R.L. Coffman, A. Sher, and R.A. Seder Vaccine adjuvants: putting innate immunity to work Immunity 33 2010 492 503
2. L.A. Mitchell, A.J. Henderson, and S.W. Dow Suppression of vaccine immunity by inflammatory monocytes J Immunol 189 2012 5612 5621
3. D.I. Gabrilovich, and S. Nagaraj Myeloid-derived suppressor cells as regulators of the immune system Nat Rev Immunol 9 2009 162 174
4. A. Martino, E. Badell, V. Abadie, V. Balloy, M. Chignard, and M.Y. Mistou Mycobacterium bovis bacillus Calmette-Guerin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo T cell priming via IL-1R-dependent nitric oxide production J Immunol 184 2010 2038 2047
5. Bosschaerts T, Guilliams M, Stijlemans B, Morias Y, Engel D, Tacke F, et al. Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signaling. PLoS Pathog 6:e1001045.
6. Anthony DD, Umbleja T, Aberg JA, Kang M, Medvik K, Lederman MM, et al. Lower peripheral blood CD14 + monocyte frequency and higher CD34 + progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals. Vaccine 29:3558-63.
7. I.F. Charo, and R.M. Ransohoff The many roles of chemokines and chemokine receptors in inflammation N Engl J Med 354 2006 610 621
8. C. Shi, and E.G. Pamer Monocyte recruitment during infection and inflammation Nat Rev Immunol 11 2011 762 774
9. C.M. Brodmerkel, R. Huber, M. Covington, S. Diamond, L. Hall, and R. Collins Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344 J Immunol 175 2005 5370 5378
10. Min SH, Wang Y, Gonsiorek W, Anilkumar G, Kozlowski J, Lundell D, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis. Biochem Biophys Res Commun 391:1080-6.
11. N.A. Nelken, S.R. Coughlin, D. Gordon, and J.N. Wilcox Monocyte chemoattractant protein-1 in human atheromatous plaques J Clin Invest 88 1991 1121 1127
12. Dow DJ, McMahon AD, Gray IC, Packard CJ, Groot PH. CCR2 and coronary artery disease: a woscops substudy. BMC Res Notes 3:31.
13. C.E. Vergunst, D.M. Gerlag, L. Lopatinskaya, L. Klareskog, M.D. Smith, and F. van den Bosch Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial Arthritis Rheum 58 2008 1931 1939
14. Proudfoot AE, Power CA, Schwarz MK. Anti-chemokine small molecule drugs: a promising future? Expert Opin Investig Drugs 19:345-55.
15. T. Mirzadegan, F. Diehl, B. Ebi, S. Bhakta, I. Polsky, and D. McCarley Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle J Biol Chem 275 2000 25562 25571
16. Gibon E, Ma T, Ren PG, Fritton K, Biswal S, Yao Z, et al. Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles. J Orthop Res 30:547-53.
17. S.W. Dow, L.G. Fradkin, D.H. Liggitt, A.P. Willson, T.D. Heath, and T.A. Potter Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously J Immunol 163 1999 1552 1561
18. M. Ishibashi, K. Egashira, Q. Zhao, K. Hiasa, K. Ohtani, and Y. Ihara Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice Arterioscler Thromb Vasc Biol 24 2004 e174 e178
19. M. Ishibashi, K. Hiasa, Q. Zhao, S. Inoue, K. Ohtani, and S. Kitamoto Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling Circ Res 94 2004 1203 1210
20. Z. Zhu, B. Ma, T. Zheng, R.J. Homer, C.G. Lee, and I.F. Charo IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling J Immunol 168 2002 2953 2962
21. Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475:222-5.
22. S. Abel, D.J. Back, and M. Vourvahis Maraviroc: pharmacokinetics and drug interactions Antivir Ther 14 2009 607 618
23. S. Abel, J.D. Davis, C.E. Ridgway, J.C. Hamlin, and M. Vourvahis Pharmacokinetics, safety and tolerability of a single oral dose of maraviroc in HIV-negative subjects with mild and moderate hepatic impairment Antivir Ther 14 2009 831 837
24. C.L. Tsou, W. Peters, Y. Si, S. Slaymaker, A.M. Aslanian, and S.P. Weisberg Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites J Clin Invest 117 2007 902 909
25. V.C. Huber, R.M. McKeon, M.N. Brackin, L.A. Miller, R. Keating, and S.A. Brown Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza Clin Vaccine Immunol 13 2006 981 990
26. S. Pillet, D. Kobasa, I. Meunier, M. Gray, D. Laddy, and D.B. Weiner Cellular immune response in the presence of protective antibody levels correlates with protection against 1918 influenza in ferrets Vaccine 29 2011 6793 6801