Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles

Journal of Orthopaedic Research

Volumn 30, Issue 4, 2012, Pages 547-553

  Gibon, Emmanuel ^a,b   Ma, Ting ^a   Ren, Pei Gen ^a   Fritton, Kate ^a   Biswal, Sandip ^a   Yao, Zhenyu ^a   Smith, Lane ^a   Goodman, Stuart B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

arthroplasty; macrophage recruitment; MCP 1; osteolysis; UHMWPE particles

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; MONOCYTE CHEMOTACTIC PROTEIN 1; RS 102895; ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CELL MIGRATION; CONTROLLED STUDY; FEMUR; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MOUSE; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL;

ANIMALS; ARTHROPLASTY, REPLACEMENT; BONE DENSITY; CELL LINE; CHEMOKINE CCL2; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; FEMUR; MACROPHAGES; MICE; MICE, KNOCKOUT; MICE, NUDE; MOLECULAR WEIGHT; OSTEOLYSIS; PARTICLE SIZE; POLYETHYLENE; PROSTHESIS FAILURE; RECEPTORS, CCR2; X-RAY MICROTOMOGRAPHY;

EID: 84857030878     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21548     Document Type: Article

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