Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with nonpyridinium oximes

Biochemical Journal

Volumn 450, Issue 1, 2013, Pages 231-242

  Radiæ, Zoran ^a   Dale, Trevor ^b   Kovarik, Zrinka ^c   Berend, Suzana ^c   Garcia, Edzna ^a   Zhang, Limin ^a   Amitai, Gabriel ^d   Green, Carol ^e   Radiæ, Božica ^c   Duggan, Brendan M ^a   Ajami, Dariush ^b   Rebek, Julius ^b   Taylor, Palmer ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^d ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^e SRI INTERNATIONAL   (United States)

Author keywords

Butyrylcholinesterase reactivation; Catalytic organophosphate bioscavenger; Edrophonium analogue; Nonpyridinium oxime reactivator; Organophosphate intoxication; Oxime reactivation

Indexed keywords

2 TRIMETHYLAMMONIO 6 HYDROXYBENZALDEHYDE OXIME; 4 TRIMETHYLAMMONIO 2 HYDROXY BENZALDEHYDE OXIME; ANTIDOTE; ATROPINE; CHOLINESTERASE; CYCLOSARIN; EDROPHONIUM; HYDROXYL GROUP; NITROGEN; NUCLEOPHILE; ORGANOPHOSPHATE PESTICIDE; PARAOXON; PRALIDOXIME IODIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYST; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETOXIFICATION; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG MECHANISM; EX VIVO STUDY; FEMALE; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; KINETICS; MALE; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; ORGANOPHOSPHATE POISONING; PH; PRIORITY JOURNAL; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

EID: 84873037091     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121612     Document Type: Article

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