Discovery of novel inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 301-310

  Zhang, Mingming ^a   Zhu, Weiliang ^b   Li, Yingxia ^a,b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antitumor activity; Cell viability; Small molecule inhibitors; STAT3 signaling; Virtual screening

Indexed keywords

2 CHLORO N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL)PROPANAMIDE; 4 (BENZYLOXY) N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL)BENZAMIDE; 4 (BENZYLOXY) N (2 ((2 OXO 2 ((1 PHENYLETHYL)AMINO)THIO)BENZO[D]THIAZOL 6 YL)BENZAMIDE; 4 BUTOXY N (2 ((2 OXO 2 ((1 PHENYLETHYL)AMINO)ETHYL) THIO)BENZO[D]THIAZOL 6 YL)BENZAMIDE; 4 METHOXY N (2 ((2 ((4 NITROBENZYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL)BENZAMIDE; 4 METHOXY N (2 ((2 OXO 2 ((1 PHENYLETHYLL)AMINO)ETHYL)THIO)BENZO[D]THIAZOL 6 YL)BENZAMIDE; BENZOTHIAZOLE; INTERLEUKIN 6; LUCIFERASE; MOLECULAR SCAFFOLD; N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL) 2 METHOXYBENZAMIDE; N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL) 4 (PENTYLOXY)BENZAMIDE; N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL) 4 METHOXYBENZAMIDE; N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL) 4 NITROBENZAMIDE; N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL)CYCLOPROPANE CARBOXAMIDE; N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL)ISOBUTYRAMIDE; N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL)ISONICOTINAMIDE; N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL)NICOTINAMIDE; N (2 ((2 ((2,6 DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL)PROPIONAMIDE; N (2 ((2 ((2,6 DIMETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL) 2 METHOXYBENZAMIDE; N (2 ((2 ((2,6 DIMETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL) 4 METHOXYBENZAMIDE; N (2 ((2 ((3 CHLORO 4 FLUOROPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL) 4 METHOXYBENZAMIDE; N (2 ((2 ((3 CHLORO 4 FLUOROPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL)BENZAMIDE; N (2 ((2 ((4 FLUOROBENZYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL) 4 METHOXYBENZAMIDE; N (2 ((2 OXO 2 ((1 PHENYLETHYL)AMINO)ETHYL)THIO)BENZO[D]THIAZOL 6 YL) 4 (PENTAN 2 YLOXY)BENZAMIDE; N (2 ((2 OXO 2 ((1 PHENYLETHYL)AMINO)ETHYL)THIO)BENZO[D]THIAZOL 6 YL) 4 (PENTYLOXY)BENZAMIDE; N (2,6 DIETHYLPHENYL) 2 ((6 (2 (2 METHOXYPHENYL)ACETAMIDO)BENZO[D]THIAZOL 2 YL)THIO)ACETAMIDE; PROTEIN INHIBITOR OF ACTIVATED STAT; STAT3 PROTEIN; TN (2 ((2 ((2, DIETHYLPHENYL)AMINO) 2 OXOETHYL)THIO)BENZO[D]THIAZOL 6 YL) 4 (PENTAN 2 YLOXY)BENZAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CELL VIABILITY; CONTROLLED STUDY; DRUG INHIBITION; DRUG SCREENING; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; INTERLEUKIN-6; MOLECULAR STRUCTURE; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STAT3 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873029395     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.009     Document Type: Article

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