Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity

Journal of Medicinal Chemistry

Volumn 46, Issue 3, 2003, Pages 399-408

  Musso, David L ^a   Cochran, Felicia R ^a   Kelley, James L ^a,b   McLean, Ed W ^a   Selph, Jeffrey L ^a   Rigdon, Greg C ^a,c   Orr, G Faye ^a,b   Davis, Ronda G ^a   Cooper, Barrett R ^a,d   Styles, Virgil L ^a   Thompson, James B ^a   Hall, William R ^a  

^a GLAXOSMITHKLINE   (United States)

^b Icagen Inc ^*  (United States)

^c Icagen Inc   (United States)

^d Lineberry Associates   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4,6 DIFLUORO 1 INDANYLIDENE)ACETAMIDE; CINNAMIC ACID DERIVATIVE; MUSCLE RELAXANT AGENT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DOSE RESPONSE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; HYPNOTICS AND SEDATIVES; INDANS; MICE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; MUSCLE RELAXANTS, CENTRAL; RATS; RATS, INBRED LEW; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037472729     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020067s     Document Type: Article

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