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Volumn 237, Issue 12, 2012, Pages 1369-1378

Amino acids as metabolic substrates during cardiac ischemia

Author keywords

Amino acids; Cardiac; Cardioprotection; Ischemia; Metabolism

Indexed keywords

ACETYL COENZYME A; ALANINE; AMINO ACID; AMINOOXYACETIC ACID; ASPARAGINE; ASPARTIC ACID; CYCLOSERINE; FATTY ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; KETONE BODY; LACTIC ACID; OXYGEN; PYRUVIC ACID; TRIMETAZIDINE;

EID: 84873028506     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2012.012025     Document Type: Review
Times cited : (104)

References (56)
  • 1
    • 43949150714 scopus 로고
    • Energy-metabolism of the heart-from basic concepts to clinical-applications
    • Taegtmeyer H. Energy-metabolism of the heart-from basic concepts to clinical-applications. Curr Probl Cardiol 1994;19:61-113
    • (1994) Curr Probl Cardiol , vol.19 , pp. 61-113
    • Taegtmeyer, H.1
  • 2
    • 0015593381 scopus 로고
    • Metabolism and electrical-activity of anoxic ventricular muscle
    • McDonald TF, Macleod DP. Metabolism and electrical-activity of anoxic ventricular muscle. J Physiol London 1973;229:559-82
    • (1973) J Physiol London , vol.229 , pp. 559-582
    • McDonald, T.F.1    McLeod, D.P.2
  • 3
    • 0024388681 scopus 로고
    • Ionic mechanisms of the depression of automaticity and conduction in the rabbit atrioventricular node caused by hypoxia or metabolic inhibition and protective action of glucose and valine
    • Nishimura M, Tanaka H, Homma N, Matsuzawa T, Watanabe Y. Ionic mechanisms of the depression of automaticity and conduction in the rabbit atrioventricular node caused by hypoxia or metabolic inhibition and protective action of glucose and valine. Am J Cardiol 1989;64:J24-8
    • (1989) Am J Cardiol , vol.64
    • Nishimura, M.1    Tanaka, H.2    Homma, N.3    Matsuzawa, T.4    Watanabe, Y.5
  • 4
    • 0018872220 scopus 로고
    • Comparison of the effects of regional ischemia, hypoxia, hyperkalemia, and acidosis on intracellular and extracellular potentials and metabolism in the isolated porcine heart
    • Morena H, Janse MJ, Fiolet JWT, Krieger WJG, Crijns H, Durrer D. Comparison of the effects of regional ischemia, hypoxia, hyperkalemia, and acidosis on intracellular and extracellular potentials and metabolism in the isolated porcine heart. Circul Res 1980;46:634-46
    • (1980) Circul Res , vol.46 , pp. 634-646
    • Morena, H.1    Janse, M.J.2    Fiolet, J.W.T.3    Krieger, W.J.G.4    Crijns, H.5    Durrer, D.6
  • 5
    • 0019543906 scopus 로고
    • Alterations of carbohydrate and lipid-metabolism in the acutely ischemic heart
    • Liedtke AJ. Alterations of carbohydrate and lipid-metabolism in the acutely ischemic heart. Progress in Cardiovasc Dis 1981;23:321-36
    • (1981) Progress in Cardiovasc Dis , vol.23 , pp. 321-336
    • Liedtke, A.J.1
  • 6
    • 0023615778 scopus 로고
    • Glycolysis preferentially inhibits ATP-sensitive K+ channels in isolated Guinea-pig cardiac myocytes
    • Weiss JN, Lamp ST. Glycolysis preferentially inhibits ATP-sensitive K+ channels in isolated Guinea-pig cardiac myocytes. Science 1987;238:67-9
    • (1987) Science , vol.238 , pp. 67-69
    • Weiss, J.N.1    Lamp, S.T.2
  • 7
    • 0024521795 scopus 로고
    • Simultaneous measurements of action potential duration and intracellular ATP in isolated ferret hearts exposed to cyanide
    • Elliott AC, Smith GL, Allen DG. Simultaneous measurements of action potential duration and intracellular ATP in isolated ferret hearts exposed to cyanide. Circ Res 1989;64:583-91
    • (1989) Circ Res , vol.64 , pp. 583-591
    • Elliott, A.C.1    Smith, G.L.2    Allen, D.G.3
  • 8
    • 50449119332 scopus 로고
    • Metabolism of the human heart II. Studies on fat, ketone and amino acid metabolism
    • Bing RJ, Siegel A, Ungar I, Gilbert M. Metabolism of the human heart II. Studies on fat, ketone and amino acid metabolism. Am J Mede 1954;16:504-15
    • (1954) Am J Mede , vol.16 , pp. 504-515
    • Bing, R.J.1    Siegel, A.2    Ungar, I.3    Gilbert, M.4
  • 9
    • 0000668980 scopus 로고
    • Cardiac metabolism
    • Bing RJ. Cardiac metabolism. Physiol Rev 1965;45:171-213
    • (1965) Physiol Rev , vol.45 , pp. 171-213
    • Bing, R.J.1
  • 11
    • 0034847452 scopus 로고    scopus 로고
    • Interaction between glutamine availability and metabolism of glycogen, tricarboxylic acid cycle intermediates and glutathione
    • Rennie MJ, Bowtell JL, Bruce M, Khogali SEO. Interaction between glutamine availability and metabolism of glycogen, tricarboxylic acid cycle intermediates and glutathione. J Nutr 2001;131:2488S-90S
    • (2001) J Nutr , vol.131
    • Rennie, M.J.1    Bowtell, J.L.2    Bruce, M.3    Khogali, S.E.O.4
  • 13
    • 0030792690 scopus 로고    scopus 로고
    • Substrate metabolism as a determinant for postischemic functional recovery of the heart
    • Taegtmeyer H, Goodwin GW, Doenst T, Frazier OH. Substrate metabolism as a determinant for postischemic functional recovery of the heart. Am J Cardiol 1997;80:3A-10A
    • (1997) Am J Cardiol , vol.80
    • Taegtmeyer, H.1    Goodwin, G.W.2    Doenst, T.3    Frazier, O.H.4
  • 14
    • 34247231646 scopus 로고    scopus 로고
    • Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts
    • Sorokina N, O'Donnell JM, McKinney RD, Pound KM, Woldegiorgis G, LaNoue KF, Ballal K, Taegtmeyer H, Buttrick PM, Lewandowski ED. Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts. Circulation 2007;115:2033-41
    • (2007) Circulation , vol.115 , pp. 2033-2041
    • Sorokina, N.1    O'Donnell, J.M.2    McKinney, R.D.3    Pound, K.M.4    Woldegiorgis, G.5    LaNoue, K.F.6    Ballal, K.7    Taegtmeyer, H.8    Buttrick, P.M.9    Lewandowski, E.D.10
  • 15
    • 79955456000 scopus 로고    scopus 로고
    • Branched-chain amino acid metabolism in heart disease: An epiphenomenon or a real culprit?
    • Huang Y, Zhou M, Sun H, Wang Y. Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit? Cardiovasc Res 2011;90:220-3
    • (2011) Cardiovasc Res , vol.90 , pp. 220-223
    • Huang, Y.1    Zhou, M.2    Sun, H.3    Wang, Y.4
  • 16
    • 44449104602 scopus 로고    scopus 로고
    • More than bricks and mortar: Comments on protein and amino acid metabolism in the heart
    • Taegtmeyer H, Harinstein ME, Gheorghiade M. More than bricks and mortar: comments on protein and amino acid metabolism in the heart. Am J Cardiol 2008;101(Suppl. S):3E-7E
    • (2008) Am J Cardiol , vol.101 , Issue.SUPPL. S
    • Taegtmeyer, H.1    Harinstein, M.E.2    Gheorghiade, M.3
  • 19
    • 33750048135 scopus 로고    scopus 로고
    • L-glutamate and glutamine improve haemodynamic function and restore myocardial glycogen content during postischaemic reperfusion: A radioactive tracer study in the rat isolated heart
    • Stottrup NB, Kristiansen SB, Lofgren B, Hansen BF, Kimose HH, Botker HE, Nielsen TT. L-glutamate and glutamine improve haemodynamic function and restore myocardial glycogen content during postischaemic reperfusion: a radioactive tracer study in the rat isolated heart. Clin Exp Pharmacol Physiol 2006;33:1099-103
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 1099-1103
    • Stottrup, N.B.1    Kristiansen, S.B.2    Lofgren, B.3    Hansen, B.F.4    Kimose, H.H.5    Botker, H.E.6    Nielsen, T.T.7
  • 20
    • 33845632951 scopus 로고    scopus 로고
    • Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels
    • Liu J, Marchase RB, Chatham JC. Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels. J Mol Cell Cardiol 2007;42:177-85
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 177-185
    • Liu, J.1    Marchase, R.B.2    Chatham, J.C.3
  • 21
    • 0017107233 scopus 로고
    • Alterations of myocardial amino-acid metabolism in chronic ischemic heart-disease
    • Mudge GH, Mills RM, Taegtmeyer H, Gorlin R, Lesch M. Alterations of myocardial amino-acid metabolism in chronic ischemic heart-disease. J Clin Investig 1976;58:1185-92
    • (1976) J Clin Investig , vol.58 , pp. 1185-1192
    • Mudge, G.H.1    Mills, R.M.2    Taegtmeyer, H.3    Gorlin, R.4    Lesch, M.5
  • 26
    • 0015217664 scopus 로고
    • Regulation of protein synthesis in heart muscle. I. Effect of amino acid levels on protein synthesis
    • Morgan HE, Earl DCN, Broadus A, Wolpert EB, Giger KE, Jefferson LS. Regulation of protein synthesis in heart muscle. I. Effect of amino acid levels on protein synthesis. J Biol Chem 1971;246:2152-2162
    • (1971) J Biol Chem , vol.246 , pp. 2152-2162
    • Morgan, H.E.1    Earl, D.C.N.2    Broadus, A.3    Wolpert, E.B.4    Giger, K.E.5    Jefferson, L.S.6
  • 29
    • 0025614783 scopus 로고
    • Studies of myocardial protection in the immature heart. II. Evidence for importance of amino acid metabolism in tolerance to ischemia
    • Julia P, Young HH, Buckberg GD, Kofsky ER, Bugyi HI. Studies of myocardial protection in the immature heart. II. Evidence for importance of amino acid metabolism in tolerance to ischemia. J Thorac Cardiovasc Surg 1990;100:888-95
    • (1990) J Thorac Cardiovasc Surg , vol.100 , pp. 888-895
    • Julia, P.1    Young, H.H.2    Buckberg, G.D.3    Kofsky, E.R.4    Bugyi, H.I.5
  • 30
    • 0017066492 scopus 로고
    • Metabolic-regulation in ischemia and hypoxia-effects of anoxia and regional ischemia on metabolism of glucose and fatty-acids
    • Opie LH. Metabolic-regulation in ischemia and hypoxia-effects of anoxia and regional ischemia on metabolism of glucose and fatty-acids. Cardiovasc Res 1976;38:52-74
    • (1976) Cardiovasc Res , vol.38 , pp. 52-74
    • Opie, L.H.1
  • 31
    • 1842389677 scopus 로고
    • Relationship between carbohydrate and lipid-metabolism and energy-balance of heart-muscle
    • Neely JR, Morgan HE. Relationship between carbohydrate and lipid-metabolism and energy-balance of heart-muscle. Annu Rev Physiol 1974;36:413-59
    • (1974) Annu Rev Physiol , vol.36 , pp. 413-459
    • Neely, J.R.1    Morgan, H.E.2
  • 32
    • 0034509885 scopus 로고    scopus 로고
    • Metabolic adaptation of the hypertrophied heart: Role of the malate/aspartate and alpha-glycerophosphate shuttles
    • Rupert BE, Segar JL, Schutte BC, Scholz TD. Metabolic adaptation of the hypertrophied heart: role of the malate/aspartate and alpha-glycerophosphate shuttles. J Mol Cell Cardiol 2000;32:2287-97
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 2287-2297
    • Rupert, B.E.1    Segar, J.L.2    Schutte, B.C.3    Scholz, T.D.4
  • 33
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005;85:1093-129
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 34
    • 0026675179 scopus 로고
    • Cardiac metabolism-emergence, decline, and resurgence 2
    • Opie LH. Cardiac metabolism-emergence, decline, and resurgence 2. Cardiovasc Res 1992;26:817-30
    • (1992) Cardiovasc Res , vol.26 , pp. 817-830
    • Opie, L.H.1
  • 36
    • 0035692672 scopus 로고    scopus 로고
    • Glutamate-loading stimulates metabolic flux and improves cell recovery following chemical hypoxia in isolated cardiomyocytes
    • Williams H, King N, Griffiths EJ, Suleiman MS. Glutamate-loading stimulates metabolic flux and improves cell recovery following chemical hypoxia in isolated cardiomyocytes. J Mol Cell Cardiol 2001;33:2109-19
    • (2001) J Mol Cell Cardiol , vol.33 , pp. 2109-2119
    • Williams, H.1    King, N.2    Griffiths, E.J.3    Suleiman, M.S.4
  • 37
    • 67349280855 scopus 로고    scopus 로고
    • Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione
    • Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R, Klimberg VS. Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione. Nutrition 2009;25:812-7
    • (2009) Nutrition , vol.25 , pp. 812-817
    • Todorova, V.1    Vanderpool, D.2    Blossom, S.3    Nwokedi, E.4    Hennings, L.5    Mrak, R.6    Klimberg, V.S.7
  • 38
    • 70349755734 scopus 로고    scopus 로고
    • Glutamine administration in patients undergoing cardiac surgery and the influence on blood glutathione levels
    • Engel JM, Muhling J, Kwapisz M, Heidt M. Glutamine administration in patients undergoing cardiac surgery and the influence on blood glutathione levels. Acta Anaesthesiol Scand 2009;53:1317-23
    • (2009) Acta Anaesthesiol Scand , vol.53 , pp. 1317-1323
    • Engel, J.M.1    Muhling, J.2    Kwapisz, M.3    Heidt, M.4
  • 41
    • 0029993314 scopus 로고    scopus 로고
    • Transport and metabolism of L-glutamate during oxygenation, anoxia, and reoxygenation of rat cardiac myocytes
    • Dinkelborg LM, Kinne RKH, Grieshaber MK. Transport and metabolism of L-glutamate during oxygenation, anoxia, and reoxygenation of rat cardiac myocytes. Am J Physiol Heart Circ Physiol 1996;39:H1825-32
    • (1996) Am J Physiol Heart Circ Physiol , vol.39
    • Dinkelborg, L.M.1    Kinne, R.K.H.2    Grieshaber, M.K.3
  • 42
    • 0029892792 scopus 로고    scopus 로고
    • Molecular biology of mammalian amino acid transporters
    • Malandro MS, Kilberg MS. Molecular biology of mammalian amino acid transporters. Annu Rev Biochem 1996;65:305-36
    • (1996) Annu Rev Biochem , vol.65 , pp. 305-336
    • Malandro, M.S.1    Kilberg, M.S.2
  • 43
    • 0345688036 scopus 로고    scopus 로고
    • Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradation
    • Razeghi P, Sharma S, Ying J, Li YP, Stepkowski S, Reid MB, Taegtmeyer H. Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradation. Circulation 2003;108:2536-41
    • (2003) Circulation , vol.108 , pp. 2536-2541
    • Razeghi, P.1    Sharma, S.2    Ying, J.3    Li, Y.P.4    Stepkowski, S.5    Reid, M.B.6    Taegtmeyer, H.7
  • 45
    • 0035823277 scopus 로고    scopus 로고
    • NMR indirect detection of glutamate to measure citric acid cycle flux in the isolated perfused mouse heart
    • Burgess SC, Babcock EE, Jeffrey FMH, Sherry AD, Malloy CR. NMR indirect detection of glutamate to measure citric acid cycle flux in the isolated perfused mouse heart. FEBS Lett 2001;505:163-7
    • (2001) FEBS Lett , vol.505 , pp. 163-167
    • Burgess, S.C.1    Babcock, E.E.2    Jeffrey, F.M.H.3    Sherry, A.D.4    Malloy, C.R.5
  • 48
    • 84873040022 scopus 로고    scopus 로고
    • Peptide and protein analysis using ion mobility-mass spectrometry
    • In: Gross ML, Chen G, Pramanik B, eds., Hoboken, NJ, John Wiley & Sons, Inc
    • Enders JR, Kliman M, Sundarapandian S, Mclean JA. Peptide and protein analysis using ion mobility-mass spectrometry. In: Gross ML, Chen G, Pramanik B, eds. Peptide and Protein Mass Spectrometry in Drug Discovery. Hoboken, NJ, John Wiley & Sons, Inc., 2011:139-174
    • (2011) Peptide and Protein Mass Spectrometry in Drug Discovery , pp. 139-174
    • Enders, J.R.1    Kliman, M.2    Sundarapandian, S.3    McLean, J.A.4
  • 49
  • 50
    • 84856474082 scopus 로고    scopus 로고
    • Structural mass spectrometry: Rapid methods for separation and analysis of peptide natural products
    • Goodwin CR, Fenn LS, Derewacz DK, Bachmann BO, McLean JA. Structural mass spectrometry: rapid methods for separation and analysis of peptide natural products. J Nat Prod 2012;75:48-53
    • (2012) J Nat Prod , vol.75 , pp. 48-53
    • Goodwin, C.R.1    Fenn, L.S.2    Derewacz, D.K.3    Bachmann, B.O.4    McLean, J.A.5
  • 51
    • 77954793993 scopus 로고    scopus 로고
    • Peptide quantitation using primary amine selective metal chelation labels for mass spectrometry
    • Kerr TJ, McLean JA. Peptide quantitation using primary amine selective metal chelation labels for mass spectrometry. Chem Commun 2010;46:5479-81
    • (2010) Chem Commun , vol.46 , pp. 5479-5481
    • Kerr, T.J.1    McLean, J.A.2
  • 52
    • 84873022559 scopus 로고    scopus 로고
    • Evidence of efficacy of metabolic agents
    • Marzilli M, Affinito S. Evidence of efficacy of metabolic agents. Heart Metab 2005;27:21-3
    • (2005) Heart Metab , vol.27 , pp. 21-23
    • Marzilli, M.1    Affinito, S.2
  • 53
    • 0012120372 scopus 로고    scopus 로고
    • Trimetazidine: A metabolic agent for the treatment of stable angina
    • Marzilli M. Trimetazidine: a metabolic agent for the treatment of stable angina. Euro Heart J Suppl 2001;3:O12-5
    • (2001) Euro Heart J Suppl , vol.3
    • Marzilli, M.1
  • 55
    • 64749109727 scopus 로고    scopus 로고
    • A meta-analysis of cardiac electrophysiology computational models
    • Niederer SA, Fink M, Noble D, Smith NP. A meta-analysis of cardiac electrophysiology computational models. Exp Physiol 2009;94:486-95
    • (2009) Exp Physiol , vol.94 , pp. 486-495
    • Niederer, S.A.1    Fink, M.2    Noble, D.3    Smith, N.P.4


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