Substrate metabolism as a determinant for postischemic functional recovery of the heart

American Journal of Cardiology

Volumn 80, Issue 3 A, 1997, Pages 3A-10A

  Taegtmeyer, Heinrich ^a   Goodwin, Gary W ^a   Doenst, Torsten ^a   Frazier, O Howard ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; OXYGEN; POTASSIUM;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; ENERGY TRANSFER; ENZYME METABOLISM; GLUCOSE TRANSPORT SYSTEM; GLYCOGEN METABOLISM; HEART FAILURE; HEART LEFT VENTRICLE PERFORMANCE; HEART MUSCLE ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030792690     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(97)00452-9     Document Type: Conference Paper

References (62)

1. Bunger R, Mallet RT, Hartman DA. Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure. Eur J Biochem. 180:1989;221-233.
2. Doenst T, Guthrie PH, Chemnitius J-M, Zech R, Taegtmeyer H. Fasting, lactate, and insulin improve ischemia tolerance: a comparison with ischemic preconditioning. Am J Physiol. 270:1996;Hl6O7-Hl6l5.
3. Goodwin GW, Taegtmeyer H. Metabolic recovery of the isolated working rat heart after brief global ischemia. Am J Physiol. 267:1994;H462-H470.
4. Jeremy RW, Koretsune Y, Marban E, Becker LC. Relation between glycolysis and calcium homeostasis in postischemic myocardium. Circ Res. 70:1992;1180-1190.
5. Lerch R. Oxidative substrate metabolism during postischemic reperfusion. Basic Res Cardiol. 88:1993;525-544.
6. Lewandowski ED, White LT. Pyruvate dehydrogense influences postischemic heart function. Circulation. 91:1995;2071-2079.
7. Liedtke AJ, DeMaison L, Eggelston AM, Cohen LM, Nellis SH. Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium. Circ Res. 62:1988;535-542.
8. 2 during reperfusion of ischemic hearts. Am J Physiol. 270:1996;H72-H80.
9. Lopaschuk GD, Spafford MA, Davies NJ, Wall SR. Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia. Circ Res. 66:1990;546-553.
10. Mallet RT, Hartman DA, Bünger R. Glucose requirement for postischemic recovery of perfused working heart. Eur J Biochem. 188:1990;481-493.
11. McVeigh JJ, Lopaschuk GD. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am J Physiol. 259:1990;HlO79-H1085.
12. Sako EY, Kingsley-Hickman PB, From AHL, Ugurbil K, Foker JE. Substrate effects in the postischemic myocardium. J Surg Res. 44:1988;430-435.
13. Taegtmeyer H, Roberts AFC, Rayne AEG. Energy metabolism in reperfused rat heart: return of function before normalization of ATP content. J Am Coll Cardiol. 6:1985;864-870.
14. Tamm C, Benzi RH, Papageorgiou I, Tardy I, Lerch R. Substrate competition in postischemic myocardium. Effect of substrate availability during reperfusion on metabolic and contractile recovery in isolated rat hearts. Circ Res. 75:1994;1103-1112.
15. Gradinak S, Coleman GM, Taegtmeyer H, Sweeney MS, Frazier OH. Improved cardiac function with glucose-insulin-potassium after coronary bypass surgery. Ann Thorac Surg. 48:1989;484-489.
16. Haider W, Eckersberger F, Wolner E. Preventive insulin administration for myocardial protection in cardiac surgery. Anesthesiology. 60:1984;422-429.
17. Lazar HL. Enhanced preservation of acutely ischemic myocardium using glucose-insulin-potassium solutions. J Card Surg. 9:((suppl)):1994;474-478.
18. Taegtmeyer H, Villalobos DH. Metabolic support for the postischaemic heart. Lancet. 345:1995;1552-1555.
19. Taegtmeyer H, Hems R, Krebs HA. Utilization of energy providing substrates in the isolated working rat heart. Biochem J. 186:1980;701-711.
20. Bolukoglu H, Goodwin GW, Guthrie PH, Carmical SG, Chen TM, Taegtmeyer H. Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart. Am J Physiol. 270:1996;H817-H826.
21. Neely JR, Grotyohann LW. Role of glycolytic products in damage to myocardium: dissociation of adenosine triphosphate levels and recovery of function of reperfused canine myocardium. Circ Res. 55:1984;816-824.
22. Schneider CA, Nguyêñ VTB, Taegtmeyer H. Feeding and fasting determine postischemic glucose utilization in isolated working rat hearts. Am J Physiol. 260:1991;H542-H548.
23. Schneider CA, Taegtmeyer H. Fasting in vivo delays myocardial cell damage after brief periods of ischemia in the isolated working rat heart. Circ Res. 68:1991;1045-1050.
24. Asimakis G. Myocardial glycogen depletion cannot explain the cardioprotective effects of ischemic preconditioning in the rat heart. J Mol Cell Cardiol. 28:1996;563-570.
25. Cross HR, Opie LH, Radda GK, Clarke K. Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved. Circ Res. 78:1996;482-491.
26. Depré C, Hue L. Improvement of postischemic functional recovery by increasing glycogen content in the isolated working rat heart. (Abstr.) J Am Coll Cardiol 1994:263A.
27. Lopaschuk GD, Saddik M. The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia. Mol Cell Biochem. 116:1992;111-116.
28. Myears D, Sobel B, Bergmaun S. Substrate use in ischemic and reperfused myocardium: quantitative considerations. Am J Physiol. 22:1987;HlO7-Hll4.
29. McCormack JG, Barr RL, Wolff AA, Lopaschuk GD. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation. 93:1996;135-142.
30. Cavallini L, Valente M, Rigobello MP. The protective action of pyruvate on recovery of ischemic rat heart, comparison with other oxidizable substrates. J Mol Cell Cardiol. 22:1990;143-154.
31. Taegtmeyer H. Energy metabolism of the heart: from basic concepts to clinical applications. Curr Prob Cardiol. 19:1994;57-116.
32. Kashiwaya Y, Sato K, Tsuchiya N, Thomas S, Fell DA, Veech RL, Passonneau JV. Control of glucose utilization in working perfused rat heart. J Biol Chem. 269:1994;25502-25514.
33. Srere P. Complexities of metabolic regulation. Trends Biochem Sci. 19:1994;519-520.
34. Harris DA, Das AM. Control of mitochondrial ATP synthesis in the heart. Biochem J. 280:1991;561-573.
35. Balaban RS. Regulation of oxidative phosphorylation in the mammalian cell. Am J Physiol. 258:1990;C377-C389.
36. Sato K, Kashiwaya Y, Keon CA, Tsuchiya N, King MT, Radda GK, Chance B, Clarke K, Veech RL. Insulin, ketone bodies, and mitochondrial energy transduction. FASEB J. 9:1995;651-658.
37. Senior AE. ATP synthesis by oxidative phosphorylation. Physiol Rev. 68:1988;177-231.
38. Hansford RG. Relation between mitochondrial calcium transport and control of energy metabolism. Rev Physiol Biochem Pharmacol. 102:1985;1-72.
39. McCormack JG, Halestrap AP, Denton RM. Role of calcium ions in reperfusion of mammalian intramitochondrial metabolism. Physiol Rev. 70:1990;391-425.
40. Taegtmeyer H. Carbohydrate interconversions and energy production. Circulation. 72:((suppl IV)):1985;1-8.
41. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. i:1963;785-789.
42. Randle PJ, Garland PB, Hales CN, Newsholme EA, Denton RM, Pogson CI. Interactions of metabolism and the physiological role of insulin. Recent Prog Horm Res. 22:1966;1-41.
43. Lopaschuk GD, Belke DD, Gamble J, ltoi T, Schonekess BO. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta. 1213:1994;263-276.
44. Krebs HA, Williamson DH, Bates MW, Page MA, Hawkins RA. The role of ketone bodies in caloric homeostasis. Weber G. Advances in Enzyme Regulation. 1971;387-409 Pergamon Press, New York.
45. Baldwin JE, Krebs HA. The evolution of metabolic cycles. Nature. 291:1981;381-382.
46. Brown GC. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem J. 284:1992;1-13.
47. Racker E. Energy cycles in health and disease. Curr Top Cell Regul. 18:1981;361-375.
48. Taegtmeyer H. Metabolic responses to cardiac hypoxia: increased production of succinate by rabbit papillary muscles. Circ Res. 43:1978;808-815.
49. Jeffrey FMH, Storey CJ, Malloy CR. Predicting functional recovery from ischemia in the rat myocardium. Basic Res Cardiol. 87:1992;548-558.
50. 18F-2-deoxy-2-fluoro-D-glucose. Am J Physiol. 259:1990;HlO22-HlO3l.
51. Lagerstrom CF, Walker WE, Taegtmeyer H. Failure of glycogen depletion to improve left ventricular function of the rabbit heart after hypothermic ischemic arrest. Circ Res. 63:1988;81-86.
52. Apstein CS, Gravino FN, Haudenschild CC. Determinants of a protective effect of glucose and insulin on the ischemic myocardium. Effects on contractile function, diastolic compliance, metabolism, and ultrastructure during ischemia and reperfusion. Circ Res. 52:1983;515-526.
53. Eberli FR, Weinberg EO, Grice WN, Horowitz GL, Apstein CS. Protective effect of increased glycolytic substrate against systolic and diastolic dysfunction and increased coronary resistance from prolonged global underperfusion and reperfusion in isolated rabbit hearts perfused with erythrocyte suspensions. Circ Res. 68:1991;466-481.
54. Schaefer S, Carr LJ, Prussel E, Ramasamy R. Effects of glycogen depletion on ischemic injury in isolated rat hearts: insights into preconditioning. Am J Physiol. 268:1995;H935-H944.
55. Vanoverschelde J-LJ, Janier MF, Bergmann SR. The relative importance of myocardial energy metabolism compared with ischemic contracture in the determination of ischemic injury in perfused rabbit hearts. Circ Res. 74:1994;817-828.
56. Jeremy RW, Ambrosio G, Pike MM, Jacobus WE, Becker LW. The functional recovery of post-ischemic myocardium requires glycolysis during early reperfusion. J Mol Cell Cardiol. 25:1993;261-276.
57. Richwine RT, Carmical SG, Goodwin GW, Taegtmeyer H. Insulin improves post-ischemic recovery and glucose metabolism in the working rat heart perfused with oleate. Circulation. 94:((suppl)):1996;I-115.
58. Lopaschuk GD, Collins-Nakai R, Olley PM, Montague TJ, McNeil G, Gayle M, Penkoske P, Finegan BA. Plasma fatty acid levels in infants and adults after myocardial ischemia. Am Heart J. 128:1994;61-67.
59. Oliver MF, Opie LH. Effects of glucose and fatty acids on myocardial ischemia and arrhythmias. Lancet. 343:1994;155-158.
60. Sodi-Pallares D, Testelli MR, Fishleder BL, Bisteni A, Medrano GA, Friedland C, DeMicheli A. Effects of intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. Am J Cardiol. 9:1962;166-181.
61. Rackley CE, Russell RO, Rogers WJ, Papapierto SE. Clinical experience with glucose-insulin-potassium therapy in acute myocardial infarction. Am Heart J. 102:1981;1038-1049.
62. Rogers WJ, Stanley AW, Breing JB, Prather JW, McDaniel HG, Moraski RE, Mantle JA, Russell RO, Rackley CE. Reduction of hospital mortality rate of acute myocardial infarction with glucose-insulin-potassium infusion. Am Heart J. 92:1976;441-454.