A novel small-molecule screening strategy identifies mitoxantrone as a RhoGTPase inhibitor

Biochemical Journal

Volumn 450, Issue 1, 2013, Pages 55-62

  Bidaud Meynard, Aurélien ^a,b   Arma, Daniela ^a,b   Taouji, Said ^a,b,c   Laguerre, Michel ^b   Dessolin, Jean ^b   Rosenbaum, Jean ^b   Chevet, Eric ^b,c   Moreau, Violaine ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c NONE   (France)

Author keywords

AlphaScreen ; GTP competitive inhibitor; GTPase; Mitoxantrone; Rac1

Indexed keywords

F ACTIN; GUANOSINE TRIPHOSPHATE; MITOXANTRONE; PROTEIN CDC42; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; ENDOTHELIAL CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MITOXANTRONE; RAC1 GTP-BINDING PROTEIN; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SWINE;

EID: 84873026214     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120572     Document Type: Article

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