Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha-4,11-diene

FEBS Letters

Volumn 587, Issue 3, 2013, Pages 278-284

  Komori, Aya ^a,b,c   Suzuki, Munenori ^a,c   Seki, Hikaru ^a,b,c   Nishizawa, Tomoko ^b   Meyer, Jacobus Johannes Marion ^d   Shimizu, Hideaki ^b   Yokoyama, Shigeyuki ^b   Muranaka, Toshiya ^a,b,c  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Artemisia species; Artemisinin; CYP71AV1; Cytochrome P450 monooxygenase; Sesquiterpenoid; Successive oxidation

Indexed keywords

AMORPHA 4,11 DIENE; CYTOCHROME P450; CYTOCHROME P450 71AV1; ENZYME PRECURSOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTEMISIA; ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; ISOLATION PROCEDURE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; OXIDATION; PRIORITY JOURNAL; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ARTEMISIA ABSINTHIUM; ARTEMISIA ANNUA; BIOCATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDATION-REDUCTION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, NUCLEIC ACID; SESQUITERPENES; SPECIES SPECIFICITY;

AMORPHA; ARTEMISIA; ARTEMISIA ANNUA;

EID: 84872955052     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.11.031     Document Type: Article

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