Can exogenous protease inhibitors control dentin matrix degradation?

Journal of Dental Research

Volumn 91, Issue 12, 2012, Pages 1099-1102

  Carrilho, M R ^a,b  

^a WESTERN UNIVERSITY   (Canada)

^b Universidade Bandeirante de Sao Paulo   (Brazil)

Author keywords

biological products; dentin; enzymology; fibrillar collagens; hydrolases; tooth components

Indexed keywords

MATRIX METALLOPROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; CLASSIFICATION; DENTIN; DRUG EFFECT; ENZYMOLOGY; EXTRACELLULAR MATRIX; HUMAN; METABOLISM; PROTEIN DEGRADATION; TOOTH DISEASE;

DENTIN; EXTRACELLULAR MATRIX; HUMANS; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; PROTEOLYSIS; TOOTH DEMINERALIZATION;

EID: 84872925980     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034512462399     Document Type: Review

References (31)

1. Baker AH, Edwards DR, Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci. 2002 ; 115 (Pt 19). 3719-3727
2. Breschi L, Martin P, Mazzoni A, Nato F, Carrilho M, Tjäderhane L, et al. Use of a specific MMP-inhibitor (galardin) for preservation of hybrid layer. Dent Mater. 2010 ; 26: 571-578
3. Carrilho MR, Geraldeli S, Tay F, de Goes MF, Carvalho RM, Tjäderhane L, et al. In vivo preservation of the hybrid layer by chlorhexidine. J Dent Res. 2007 ; 86: 529-533
4. Chung L, Dinakarpandian D, Yoshida N, Lauer-Fields J, Fields GB, Visse R, et al. Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis. EMBO J. 2004 ; 23: 3020-3030
5. De Munck J, Van den Steen PE, Mine A, Van Landuyt KL, Poitevin A, Opdenakker G, et al. Inhibition of enzymatic degradation of adhesive-dentin interfaces. J Dent Res. 2009 ; 88: 1101-1106
6. Dickinson DP. Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease. Crit Rev Oral Biol Med. 2002 ; 13: 238-275
7. Garcia MB, Carrilho MR, Nör JE, Anauate-Netto C, Anido-Anido A, Amore R, et al. Chlorhexidine inhibits the proteolytic activity of root and coronal carious dentin in vitro. Caries Res. 2009 ; 43: 92-96
8. Garnero P, Borel O, Byrjalsen I, Ferreras M, Drake FH, McQueney MS, et al. The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem. 1998 ; 273: 32347-32352
9. Gendron R, Grenier D, Sorsa T, Mayrand D. Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine. Clin Diagn Lab Immunol. 1999 ; 6: 437-439
10. Gioia M, Monaco S, Fasciglione GF, Coletti A, Modesti A, Marini S, et al. Characterization of the mechanisms by which gelatinase A, neutrophil collagenase, and membrane-type metalloproteinase MMP-14 recognize collagen I and enzymatically process the two alpha-chains. J Mol Biol. 2007 ; 368: 1101-1113
11. Hannas AR, Pereira JC, Granjeiro JM, Tjäderhane L. The role of matrix metalloproteinases in the oral environment. Acta Odontol Scand. 2007 ; 65: 1-13
12. Hebling J, Pashley DH, Tjäderhane L, Tay FR. Chlorhexidine arrests subclinical degradation of dentin hybrid layers in vivo. J Dent Res. 2005 ; 84: 741-746
13. Hiraishi N, Yiu CK, King NM, Tay FR. Effect of chlorhexidine incorporation into a self-etching primer on dentine bond strength of a luting cement. J Dent. 2010 ; 38: 496-502
14. Kato MT, Leite AL, Hannas AR, Oliveira RC, Pereira JC, Tjäderhane L, et al. Effect of iron on matrix metalloproteinase inhibition and on the prevention of dentine erosion. Caries Res. 2010a ; 44: 309-316
15. Kato MT, Leite AL, Hannas AR, Buzalaf MA. Gels containing MMP inhibitors prevent dental erosion in situ. J Dent Res. 2010b ; 89: 468-472
16. Kato MT, Leite AL, Hannas AR, Calabria MP, Magalhães AC, Pereira JC, et al. Impact of protease inhibitors on dentin matrix degradation by collagenase. J Dent Res. 2012 ; 91: 1119-1123
17. Nascimento FD, Minciotti CL, Geraldeli S, Carrilho MR, Pashley DH, Tay FR, et al. Cysteine cathepsins in human carious dentin. J Dent Res. 2011 ; 90: 506-511
18. Niu LN, Zhang L, Jiao K, Li F, Ding YX, Wang DY, et al. Localization of MMP-2, MMP-9, TIMP-1, and TIMP-2 in human coronal dentine. J Dent. 2011 ; 39: 536-542
19. Osorio R, Yamauti M, Osorio E, Ruiz-Requena ME, Pashley DH, Tay FR, et al. Zinc reduces collagen degradation in demineralized human dentin explants. J Dent. 2011 ; 39: 148-153
20. Palosaari H, Pennington CJ, Larmas M, Edwards DR, Tjäderhane L, Salo T. Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue. Eur J Oral Sci. 2003 ; 111: 117-127
21. Pashley DH, Tay FR, Yiu C, Hashimoto M, Breschi L, Carvalho RM, et al. Collagen degradation by host-derived enzymes during aging. J Dent Res. 2004 ; 83: 216-221
22. Scaffa PM, Vidal CM, Barros N, Gesteira TF, Carmona AK, Breschi L, et al. Chlorhexidine inhibits the activity of dental cysteine cathepsins. J Dent Res. 2012 ; 91: 420-425
23. Stanislawczuk R, Reis A, Loguercio AD. A 2-year in vitro evaluation of a chlorhexidine-containing acid on the durability of resin-dentin interfaces. J Dent. 2011 ; 39: 40-47
24. Sulkala M, Wahlgren J, Larmas M, Sorsa T, Teronen O, Salo T, et al. The effects of MMP inhibitors on human salivary MMP activity and caries progression in rats. J Dent Res. 2001 ; 80: 1545-1549
25. Tersariol IL, Geraldeli S, Minciotti CL, Nascimento FD, Pääkkönen V, Martins MT, et al. Cysteine cathepsins in human dentin-pulp complex. J Endod. 2010 ; 36: 475-481
26. Tezvergil-Mutluay A, Mutluay MM, Gu LS, Zhang K, Agee KA, Carvalho RM, et al. The anti-MMP activity of benzalkonium chloride. J Dent. 2011a ; 39: 57-64
27. Tezvergil-Mutluay A, Agee KA, Uchiyama T, Imazato S, Mutluay MM, Cadenaro M, et al. The inhibitory effects of quaternary ammonium methacrylates on soluble and matrix-bound MMPs. J Dent Res. 2011b ; 90: 535-540
28. Thompson JM, Agee K, Sidow SJ, McNally K, Lindsey K, Borke J, et al. Inhibition of endogenous dentin matrix metalloproteinases by ethylenediaminetetraacetic acid. J Endod. 2012 ; 38: 62-65
29. Tjäderhane L, Larjava H, Sorsa T, Uitto VJ, Larmas M, Salo T. The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions. J Dent Res. 1998 ; 77: 1622-1629
30. Turk B, Turk D, Turk V. Lysosomal cysteine proteases: more than scavengers. Biochim Biophys Acta. 2000 ; 1477: 98-111
31. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 2003 ; 92: 827-839