Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: Optimization of cellular potency

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6135-6139

  Ameriks, Michael K ^a   Cai, Hui ^a   Edwards, James P ^a   Gebauer, Damara ^a   Gleason, Elizabeth ^a   Gu, Yin ^a   Karlsson, Lars ^a   Nguyen, Steven ^a   Sun, Siquan ^a   Thurmond, Robin L ^a   Zhu, Jian ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Cathepsin; Invariant chain; Lysosomotropism; Protease

Indexed keywords

ALKYNE DERIVATIVE; CATHEPSIN S; CATHEPSIN S INHIBITOR; FUNCTIONAL GROUP; PYRAZOLE;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; IC 50; LIPOPHILICITY; NONHUMAN; PHARMACOPHORE; PROTEIN STRUCTURE; STEREOCHEMISTRY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; CATHEPSINS; CELL LINE; DRUG DESIGN; HUMANS; MICE; PIPERIDINES; PROTEASE INHIBITORS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71749118110     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.013     Document Type: Article

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