Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 23, 2010, Pages 6890-6894

  Cai, Jiaqiang ^a   Robinson, John ^a   Belshaw, Simone ^a   Everett, Kathryn ^a   Fradera, Xavier ^a   Van Zeeland, Mario ^a   Van Berkom, Leon ^b   Van Rijnsbergen, Peter ^b   Popplestone, Lucy ^a   Baugh, Mark ^a   Dempster, Maureen ^a   Bruin, John ^a   Hamilton, William ^a   Kinghorn, Emma ^a   Westwood, Paul ^a   Kerr, Jennifer ^a   Rankovic, Zoran ^a   Arbuckle, Wullie ^a   Bennett, D Jonathan ^a   Jones, Philip S ^a   Long, Clive ^a   Martin, Iain ^a   Uitdehaag, Joost C M ^a   Meulemans, Tommi ^b   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b Mercachem BV   (Netherlands)

Author keywords

Aldehyde; Cathepsin k; Cathepsin s; Ketoamide; X ray structure

Indexed keywords

CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CATHEPSIN S INHIBITOR; CATHEPSIN V; TRIFLUOROMETHYLPHENYL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

AMIDES; ANILINE COMPOUNDS; ANIMALS; CATHEPSINS; CYSTEINE PROTEINASE INHIBITORS; FLUORINE; HUMANS; KETONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78149280634     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.012     Document Type: Article

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