Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 6, 2006, Pages 1486-1490

  Alper, Phillip B ^a   Liu, Hong ^a   Chatterjee, Arnab K ^a   Nguyen, Khanhlinh T ^a   Tully, David C ^a   Tumanut, Christine ^a   Li, Jun ^a   Harris, Jennifer L ^a   Tuntland, Tove ^a   Chang, Jonathan ^a   Gordon, Perry ^a   Hollenbeck, Thomas ^a   Karanewsky, Donald S ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

Cathepsin S; Noncovalent protease inhibitor; SAR

Indexed keywords

ANILINE DERIVATIVE; ARYLAMINOETHYLAMIDE; CATHEPSIN S; CYSTEINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

AMIDES; AMINATION; BENZENE DERIVATIVES; BINDING SITES; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; ETHANOL; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 32044464952     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.12.056     Document Type: Article

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