6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4350-4354

  Cai, Jiaqiang ^a   Baugh, Mark ^a   Black, Darcey ^a   Long, Clive ^a   Jonathan Bennett, D ^a   Dempster, Maureen ^a   Fradera, Xavier ^a   Gillespie, Jonathan ^a   Andrews, Fiona ^a   Boucharens, Sylviane ^a   Bruin, John ^a   Cameron, Kenneth S ^a   Cumming, Iain ^a   Hamilton, William ^a   Jones, Philip S ^a   Kaptein, Allard ^a   Kinghorn, Emma ^a   Maidment, Maurice ^a   Martin, Iain ^a   Mitchell, Ann ^a   Rankovic, Zoran ^a   Robinson, John ^a   Scullion, Paul ^a   Uitdehaag, Joost C M ^a   Vink, Paul ^a   Westwood, Paul ^a   Van Zeeland, Mario ^a   Van Berkom, Leon ^b   Bastiani, Martijn ^b   Meulemans, Tommi ^b   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b Mercachem BV   (Netherlands)

Author keywords

1H Imidazo 4,5 c pyridine 4 carbonitrile; Cathepsin S; Lip10

Indexed keywords

6 PHENYL 1H IMIDAZO[ 4,5 C]PYRIDINE 4 CARBONITRILE; CATHEPSIN S; CATHEPSIN S INHIBITOR; ENZYME; IMIDAZO[4,5 C]PYRIDINE DERIVATIVE; NITRILE; PROTEIN LIP 10; PYRIMIDINE 2 CARBONITRILE; PYRIMIDINE DERIVATIVE; THIOL; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; CELL ASSAY; CELL LINE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; RAT; SPLEEN;

ANIMALS; BINDING SITES; CATHEPSINS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MICE; NITRILES; PROTEASE INHIBITORS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955418622     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.072     Document Type: Article

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