Clustering of metabolic risk factors is associated with high-normal levels of liver enzymes among 6-to 8-year-old children: The PANIC study

Metabolic Syndrome and Related Disorders

Volumn 10, Issue 5, 2012, Pages 337-343

  Viitasalo, Anna ^a   Laaksonen, David E ^a,b   Lindi, Virpi ^a   Eloranta, Aino Maija ^a   Jääskeläinen, Jarmo ^b   Tompuri, Tuomo ^a,b   Väisänen, Sari ^b   Lakka, Hanna Maaria ^a   Lakka, Timo A ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CHILDHOOD DISEASE; CHILDHOOD OBESITY; CLINICAL FEATURE; DUAL ENERGY X RAY ABSORPTIOMETRY; FACTORIAL ANALYSIS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC RISK FACTOR; METABOLIC SYNDROME X; PRIORITY JOURNAL; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE;

AGE OF ONSET; BODY COMPOSITION; CHILD; CHILD NUTRITIONAL PHYSIOLOGICAL PHENOMENA; CLINICAL TRIALS AS TOPIC; CLUSTER ANALYSIS; DIET THERAPY; ENZYMES; EXERCISE THERAPY; FEMALE; HUMANS; LIVER; MALE; METABOLIC SYNDROME X; MOTOR ACTIVITY; OBESITY; OVERWEIGHT; RISK FACTORS;

EID: 84872876854     PISSN: 15404196     EISSN: 15578518     Source Type: Journal    
DOI: 10.1089/met.2012.0015     Document Type: Article

References (28)

1. Steinberger J, Daniels SR, Eckel RH, et al. Progress and challenges in metabolic syndrome in children and adolescents: A scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2009;119:628-647.
2. Kassi E, Pervanidou P, Kaltsas G, et al. Metabolic syndrome: definitions and controversies. BMC Med 2011;9:48.
3. Eisenmann JC, Laurson KR, DuBose KD, et al. Construct validity of a continuous metabolic syndrome score in children. Diabetol Metab Syndr 2010;2:8.
4. Martinez-Vizcaino V, Martinez MS, Aguilar FS, et al. Validity of a single-factor model underlying the metabolic syndrome in children: A confirmatory factor analysis. Diabetes Care 2010;33:1370-1372.
5. Olza J, Gil-Campos M, Leis R, et al. Presence of the metabolic syndrome in obese children at prepubertal age. Ann Nutr Metab 2011;58:343-350.
6. Camhi SM, Katzmarzyk PT. Tracking of cardiometabolic risk factor clustering from childhood to adulthood. Int J Pediatr Obes 2010;5:122-129.
7. Morrison JA, Friedman LA, Gray-McGuire C. Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: The Princeton Lipid Research Clinics Followup Study. Pediatrics 2007;120:340-345.
8. Morrison JA, Friedman LA, Wang P, et al. Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr 2008;152:201-206.
9. Widhalm K, Ghods E. Nonalcoholic fatty liver disease: A challenge for pediatricians. Int J Obes (Lond) 2010;34:1451-1467.
10. Rodriguez G, Gallego S, Breidenassel C, et al. Is liver transaminases assessment an appropriate tool for the screening of non-alcoholic fatty liver disease in at risk obese children and adolescents? Nutr Hosp 2010;25:712-717.
11. Ortega E, Koska J, Salbe AD, et al. Serum gamma-glutamyl transpeptidase is a determinant of insulin resistance independently of adiposity in Pima Indian children. J Clin Endocrinol Metab 2006;91:1419-1422.
12. Patel DA, Srinivasan SR, Chen W, et al. Serum alanine aminotransferase and its association with metabolic syndrome in children: The Bogalusa Heart Study. Metab Syndr Relat Disord 2011;9:211-216.
13. Saari A, Sankilampi U, Hannila ML, et al. New Finnish growth references for children and adolescents aged 0 to 20 years: Length/height-for-age, weight-for-length/height, and body mass index-for-age. Ann Med 2011;43:235-248.
14. Schwimmer JB, Deutsch R, Rauch JB, et al. Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr 2003;143:500-505.
15. Ekelund U, Anderssen SA, Froberg K, et al. Independent associations of physical activity and cardiorespiratory fitness with metabolic risk factors in children: The European Youth Heart Study. Diabetologia 2007;50:1832-1840.
16. Eloranta AM, Lindi V, Schwab U, et al. Dietary factors and their associations with socioeconomic background in Finnish girls and boys 6-8 years of age: The PANIC Study. Eur J Clin Nutr 2011;65:1211-1218.
17. Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002;288:2709-2716.
18. Laaksonen DE, Niskanen L, Nyyssonen K, et al. Dyslipidaemia as a predictor of hypertension in middle-aged men. Eur Heart J 2008;29:2561-2568.
19. Calcaterra V, Muratori T, Klersy C, et al. Early-onset metabolic syndrome in prepubertal obese children and the possible role of alanine aminotransferase as marker of metabolic syndrome. Ann Nutr Metab 2011;58:307-314.
20. Hu FB. Re: "Clustering of procoagulation, inflammation, and fibrinolysis variables with metabolic factors in insulin resistance syndrome." Am J Epidemiol 2001;153:717-718.
21. Stromme JH, Rustad P, Steensland H, et al. Reference intervals for eight enzymes in blood of adult females and males measured in accordance with the International Federation of Clinical Chemistry reference system at 37 degrees C: Part of the Nordic Reference Interval Project. Scand J Clin Lab Invest 2004;64:371-384.
22. Steinvil A, Shapira I, Ben-Bassat OK, et al. The association of higher levels of within-normal-limits liver enzymes and the prevalence of the metabolic syndrome. Cardiovasc Diabetol 2010;9:30.
23. Patel D, Srinivasan SR, Xu J, et al. Persistent elevation of liver function enzymes within the reference range is associated with increased cardiovascular risk in young adults: The Bogalusa Heart Study. Metabolism 2007;56:792-798.
24. Goessling W, Massaro JM, Vasan RS, et al. Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease. Gastroenterology 2008;135:1935-1944, 1944.e1.
25. Nguyen QM, Srinivasan SR, Xu JH, et al. Elevated liver function enzymes are related to the development of prediabetes and type 2 diabetes in younger adults: The Bogalusa Heart Study. Diabetes Care 2011;34:2603-2607.
26. Bennett B, Larson-Meyer DE, Ravussin E, et al. Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children. Obesity (Silver Spring) 2011;20:371-375.
27. Pozzato C, Radaelli G, Dall'Asta C, et al. MRI in identifying hepatic steatosis in obese children and relation to ultrasonography and metabolic findings. J Pediatr Gastroenterol Nutr 2008;47:493-499.
28. Sartorio A, Del Col A, Agosti F, et al. Predictors of nonalcoholic fatty liver disease in obese children. Eur J Clin Nutr 2007;61:877-883.